ID F1N0A3_BOVIN Unreviewed; 251 AA.
AC F1N0A3;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=VPS37D subunit of ESCRT-I {ECO:0000313|Ensembl:ENSBTAP00000011185.5};
GN Name=VPS37D {ECO:0000313|Ensembl:ENSBTAP00000011185.5,
GN ECO:0000313|VGNC:VGNC:54510};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000011185.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000011185.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000011185.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000011185.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000011185.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular
CC trafficking process. Required for the sorting of endocytic
CC ubiquitinated cargos into multivesicular bodies. May be involved in
CC cell growth and differentiation. {ECO:0000256|ARBA:ARBA00025010}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004633}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004633}.
CC -!- SIMILARITY: Belongs to the VPS37 family.
CC {ECO:0000256|ARBA:ARBA00007617}.
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DR AlphaFoldDB; F1N0A3; -.
DR STRING; 9913.ENSBTAP00000011185; -.
DR PaxDb; 9913-ENSBTAP00000011185; -.
DR Ensembl; ENSBTAT00000011185.5; ENSBTAP00000011185.5; ENSBTAG00000008487.5.
DR VEuPathDB; HostDB:ENSBTAG00000008487; -.
DR VGNC; VGNC:54510; VPS37D.
DR eggNOG; KOG3270; Eukaryota.
DR GeneTree; ENSGT00950000183012; -.
DR HOGENOM; CLU_081733_0_0_1; -.
DR InParanoid; F1N0A3; -.
DR OMA; LQVDREM; -.
DR TreeFam; TF321840; -.
DR Reactome; R-BTA-917729; Endosomal Sorting Complex Required For Transport (ESCRT).
DR Proteomes; UP000009136; Chromosome 25.
DR Bgee; ENSBTAG00000008487; Expressed in isthmus of fallopian tube and 99 other cell types or tissues.
DR GO; GO:0000813; C:ESCRT I complex; IBA:GO_Central.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IBA:GO_Central.
DR InterPro; IPR009851; Mod_r.
DR PANTHER; PTHR13678; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37; 1.
DR PANTHER; PTHR13678:SF12; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37D; 1.
DR Pfam; PF07200; Mod_r; 1.
DR PROSITE; PS51314; VPS37_C; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 93..182
FT /note="VPS37 C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51314"
FT REGION 174..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 86..143
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 209..251
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 251 AA; 27717 MW; 020D520FE8ADFCD6 CRC64;
MYRARAARAG PEPGSPGRFG ILSTGQLRDL LQDEPKLDRI VRLSRKFQGL QLEREACLAS
NYALAKENLA LRPRLEMGRT ALAIKYQELR EVAESCADKL QRLEESMHRW SPHCALGWLQ
AELEEAEQEA EEQMEQLLLG EQSLEAFLPA FQRGRALAHL RRTQAEKLQE LLRRRERSGQ
PAPTAAAEPP KSFPAAAVLP TGAARGPPAV PRSLPPLDSR PVPPLKGSPG CPLGPAPLLS
PRPSQPEPPH R
//