ID F1N0W7_BOVIN Unreviewed; 666 AA.
AC F1N0W7;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Mex-3 RNA binding family member C {ECO:0000313|Ensembl:ENSBTAP00000019818.6};
GN Name=MEX3C {ECO:0000313|Ensembl:ENSBTAP00000019818.6,
GN ECO:0000313|VGNC:VGNC:31420};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000019818.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000019818.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000019818.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000019818.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000019818.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; F1N0W7; -.
DR SMR; F1N0W7; -.
DR STRING; 9913.ENSBTAP00000019818; -.
DR PaxDb; 9913-ENSBTAP00000019818; -.
DR Ensembl; ENSBTAT00000019818.6; ENSBTAP00000019818.6; ENSBTAG00000014886.6.
DR VEuPathDB; HostDB:ENSBTAG00000014886; -.
DR VGNC; VGNC:31420; MEX3C.
DR eggNOG; KOG2113; Eukaryota.
DR GeneTree; ENSGT00940000160973; -.
DR HOGENOM; CLU_025598_2_0_1; -.
DR InParanoid; F1N0W7; -.
DR OMA; PSQTIWT; -.
DR OrthoDB; 50983at2759; -.
DR TreeFam; TF315107; -.
DR Reactome; R-BTA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR Proteomes; UP000009136; Chromosome 24.
DR Bgee; ENSBTAG00000014886; Expressed in spermatid and 105 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR CDD; cd22423; KH-I_MEX3_rpt1; 1.
DR CDD; cd22424; KH-I_MEX3_rpt2; 1.
DR CDD; cd16722; RING-HC_MEX3C; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR047228; KH-I_MEX3_rpt1.
DR InterPro; IPR047226; KH-I_MEX3_rpt2.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR047227; MEX3.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23285; RING FINGER AND KH DOMAIN CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23285:SF8; RNA-BINDING E3 UBIQUITIN-PROTEIN LIGASE MEX3C; 1.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00322; KH; 2.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50084; KH_TYPE_1; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00117}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 615..655
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..39
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..128
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 666 AA; 69873 MW; 4E37867639E8A849 CRC64;
MPSGSSAALA LAAAPAPLPQ PPPPPPPLPP PPPPPAGGPE LEGDGLLLRE RLAALGLDDP
SPAEPGAPAI RAAAAQGPAR RAAGPSPEER APPGRPGVSE AAELELEEEE DDDDEEEEEG
EDAELDGDLL EEEELEEAEE EGRPSLLLLS PPAAAASQTQ PIPGGSLGSV LLPAAGFDAR
EAAAAAAAAG VLYGGDDAQG MMAAMLSHAY GPGGCGAAAA AAALNGEQAA LLRRKSVNTT
ECVPVPSSEH VAEIVGRQGC KIKALRAKTN TYIKTPVRGE EPIFVVTGRK EDVAMAKREI
LSAAEHFSMI RASRNKNGPA LGGLSCSPNL PGQTTVQVRV PYRVVGLVVG PKGATIKRIQ
QQTHTYIVTP SRDKEPVFEV TGMPENVDRA REEIEMHIAM RTGNYIELNE ENDFHYNGTD
VSFEGGTLGS AWLSSNPVPP SRARMISNYR NDSSSSLGSG STDSYFGSNR LADFSPTSPF
STGNFWFGDT LPSVGSEDLA VDSPAFDSLP TSAQTIWTPF EPVNPLSGFG SDPPGNMKTQ
RRGSQPSTPR LSPTFPESIE HPLARRVRSD PPSTGNHVGL PIYIPAFSNG TNSYSSSNGG
STSSSPPESR RKHDCVICFE NEVIAALVPC GHNLFCMECA NKICEKRTPS CPVCQTAVTQ
AIQIHS
//
