ID F1N0X0_BOVIN Unreviewed; 1197 AA.
AC F1N0X0;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Protocadherin 12 {ECO:0000313|Ensembl:ENSBTAP00000011099.4};
GN Name=PCDH12 {ECO:0000313|Ensembl:ENSBTAP00000011099.4,
GN ECO:0000313|VGNC:VGNC:32616};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000011099.4, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000011099.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000011099.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000011099.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000011099.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F1N0X0; -.
DR SMR; F1N0X0; -.
DR STRING; 9913.ENSBTAP00000011099; -.
DR PaxDb; 9913-ENSBTAP00000011099; -.
DR Ensembl; ENSBTAT00000011099.5; ENSBTAP00000011099.4; ENSBTAG00000008437.5.
DR VEuPathDB; HostDB:ENSBTAG00000008437; -.
DR VGNC; VGNC:32616; PCDH12.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000160403; -.
DR HOGENOM; CLU_006480_1_2_1; -.
DR InParanoid; F1N0X0; -.
DR OMA; ALFMSIC; -.
DR TreeFam; TF352008; -.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000008437; Expressed in bone marrow and 90 other cell types or tissues.
DR GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016339; P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0005977; P:glycogen metabolic process; IEA:Ensembl.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:Ensembl.
DR GO; GO:0060711; P:labyrinthine layer development; IEA:Ensembl.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF42; PROTOCADHERIN-12; 1.
DR Pfam; PF00028; Cadherin; 4.
DR Pfam; PF08266; Cadherin_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1197
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003269920"
FT TRANSMEM 715..739
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..134
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 135..243
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 244..351
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 354..459
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 460..564
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 617..710
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 856..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 880..911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 972..1022
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1075..1097
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1152..1197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1165..1184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1197 AA; 129955 MW; 4C37EA2C2275EC87 CRC64;
MMRFLSLLGL LGPGGYLFLS GDCQEVATLT VRYQVAEEVP SGTVIGKLPQ ERGREEEPGQ
AGAAFQVLQL PQGLPIQVDS EDGVLSTGRR LDREQLCRQQ DPCLVSFDVL ATGERALIHV
EIQVLDINDH QPQFPKGEQE LEISESASLR TRIPLDRALD PDTGPNTLHS YTLSPSEHFA
LDVIVGPDQT KHAELVVVKE LDREIHSYFD LVLTAYDSGN PPKSGTSLVK VSVLDSNDNS
PVFAESSLAL EIQEDAAPGT LLINLTATDP DQGPNGEVEY FLSKHVPLEV LNTFNIDAKT
GQVTLLQHLD YEKNPAYEVD VQARDLGPNP IPAHCKILIK VLDVNDNAPS IHITWASQPL
LVSEALPKDS FIALIMANDL DSGNNGLVHC WLSQELGHFR LKRTNGNTYM LLTNATLDRE
QWPQYTLTLL AQDQGPQPLS DKKQLSIQIS DANDNAPVFE KSRYQVSTRE NNLPSLHLIT
IKAHDADLGV NGKISYRIQD SPVAHLVAID SDTGEVTAQR SLDYEQMASF EFLVIAEDSG
QPQLSSSVSV WVSLLDANDN APEVIHPILS NGRASLSVLV NASTGHLLVP IENPNGLGPA
GTDIPLQATS SSRPFLLVTI IARDADSGAN GELLYTIRSG NEAGVFVLSP NLGQLFINVT
NASSLTGSEW ELEIVVEDRG SPSLQTRALL QVLFVTSVDH LRDSAREPGA LSTSVLTVIC
LVVLLAVFGS ILALITSICR TEKKDNRAYN CREAESTYRH QPKRPQKQIQ KADIQLVPML
RGQVDEPGEV GQPPKHVGEE AMMEAGWDSC LQAPFHLTPT LYRTLRNQGN QGTLAESREV
LQDTVNLLFN HPRQRNASRE NLHLAEPQPA VGQPRSRLLK AAGSPTGRVP GDQGSEEAPQ
SPPASSATLR RQRNLNGKVA PEKESGPRQI LRSLVRLSVA AFAERNPVEE LTVDSPPVQQ
ISQLLSLLHQ GQFQPKPNHR GNKYLAKPGS SRSTIPDTDG PGARAGGQAE PDQEEGPLDP
EEDLSVKQLL EEELSNLLDP HTGLALDRLS VPDPAWMARL SLPLSTNYRD NVFSPDAATS
EEPRTFQTFG KAPELSPTGT RLASTFLSEM SSLLEMLLEQ RPAVPVEAAS EVLRRLSVCG
RTLSLDLATS GAAGSEGLTG LAGNKGAESR TSSGSSSSRG QWIQEPGTLG DVRKPRP
//
