ID F1N108_BOVIN Unreviewed; 649 AA.
AC F1N108;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Sodium/nucleoside cotransporter {ECO:0000256|RuleBase:RU362018};
GN Name=SLC28A1 {ECO:0000313|Ensembl:ENSBTAP00000026974.3,
GN ECO:0000313|VGNC:VGNC:34791};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000026974.3, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000026974.3, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000026974.3,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000026974.3}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000026974.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the concentrative nucleoside transporter (CNT)
CC (TC 2.A.41) family. {ECO:0000256|ARBA:ARBA00009033,
CC ECO:0000256|RuleBase:RU362018}.
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DR AlphaFoldDB; F1N108; -.
DR SMR; F1N108; -.
DR PaxDb; 9913-ENSBTAP00000026974; -.
DR Ensembl; ENSBTAT00000026974.4; ENSBTAP00000026974.3; ENSBTAG00000020250.4.
DR VEuPathDB; HostDB:ENSBTAG00000020250; -.
DR VGNC; VGNC:34791; SLC28A1.
DR eggNOG; KOG3747; Eukaryota.
DR GeneTree; ENSGT00390000016025; -.
DR HOGENOM; CLU_016813_3_2_1; -.
DR OMA; IVWHTVI; -.
DR TreeFam; TF314131; -.
DR Proteomes; UP000009136; Chromosome 21.
DR Bgee; ENSBTAG00000020250; Expressed in cortex of kidney and 54 other cell types or tissues.
DR ExpressionAtlas; F1N108; baseline.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:1901474; F:azole transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015389; F:pyrimidine- and adenosine-specific:sodium symporter activity; IEA:Ensembl.
DR GO; GO:0015213; F:uridine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015861; P:cytidine transport; IEA:Ensembl.
DR GO; GO:0180015; P:nucleoside import across plasma membrane; IEA:Ensembl.
DR InterPro; IPR008276; C_nuclsd_transpt.
DR InterPro; IPR018270; C_nuclsd_transpt_met_bac.
DR InterPro; IPR011657; CNT_C_dom.
DR InterPro; IPR002668; CNT_N_dom.
DR InterPro; IPR011642; Gate_dom.
DR NCBIfam; TIGR00804; nupC; 1.
DR PANTHER; PTHR10590; SODIUM/NUCLEOSIDE COTRANSPORTER; 1.
DR PANTHER; PTHR10590:SF16; SODIUM_NUCLEOSIDE COTRANSPORTER 1; 1.
DR Pfam; PF07670; Gate; 1.
DR Pfam; PF07662; Nucleos_tra2_C; 1.
DR Pfam; PF01773; Nucleos_tra2_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362018};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362018};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362018}; Transport {ECO:0000256|RuleBase:RU362018}.
FT TRANSMEM 82..104
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 110..129
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 152..171
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 177..196
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 263..284
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 296..319
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 339..361
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 368..387
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 429..447
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 533..557
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 569..593
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT DOMAIN 185..256
FT /note="Concentrative nucleoside transporter N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01773"
FT DOMAIN 264..362
FT /note="Nucleoside transporter/FeoB GTPase Gate"
FT /evidence="ECO:0000259|Pfam:PF07670"
FT DOMAIN 368..589
FT /note="Concentrative nucleoside transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07662"
FT REGION 33..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 649 AA; 70918 MW; 8577F3C1ADAF162A CRC64;
MEDNTPRGRE SISLTSVAIG LDNRGADLLE SLEEGRDPAG NSSPSEVGDS WSKAGPEPFS
GWRRRLQPAL RVRHFCREHA QLFRWICIGL LCTAYTAFLL AACILNFQRA LALFVLTCVV
LVFLAHSLLK RLLGPKLLRC VKPLGHPCLK LWFKRGLALA AFLGLVLWLA LDTSQRPEQL
VSFGGICVFV GFLFAVSKHH RAVSWRAVFW GLGLQFVLGL VVIRTEPGFI AFQWLGDQIQ
IFLSYTESGS SFVFGEALVK DVFAFQVLPI IVFFSCAMSV LYYVGLMQWV IMKISWLMQI
TMGTTATETL SVAGNIFVSQ TEAPLLIRPY LADMTLSEIH VVMTGGYATI AGSLLGAYIS
FGIDAASLIA ASVMAAPCAL ALSKLVYPEV EESKFRSEEG VKLTYGDAQN LLEAASSGAA
LSVKVVTNIA ANLIAFLAVL DFINAALSWL GNMVDIQGLS FQLICSYILR PVAFLMGVAW
EDCSVVAELL GMKLFLNEFV AYQGLSEYKQ RRLAGTEEWV GSKKQWISVR AEILTTFALC
GFANFSSIGI MLGGLTSMAP QRKSDFSQIV LRALCTGACV SLVNACVAGI LYMPRGPAVD
CVSLLNTTLN SSSFEVYQCC HQAFQSTGPE FSLEALDNCC RFYNHTICA
//
