ID F1N1F8_BOVIN Unreviewed; 3259 AA.
AC F1N1F8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 10-FEB-2021, entry version 62.
DE SubName: Full=Centromere protein F {ECO:0000313|Ensembl:ENSBTAP00000033816};
GN Name=CENPF {ECO:0000313|Ensembl:ENSBTAP00000033816,
GN ECO:0000313|VGNC:VGNC:27176};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000033816, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000033816}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000033816};
RG Ensembl;
RL Submitted (MAR-2016) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000033816, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000033816,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
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DR RefSeq; XP_005217426.1; XM_005217369.3.
DR STRING; 9913.ENSBTAP00000033816; -.
DR PaxDb; F1N1F8; -.
DR PRIDE; F1N1F8; -.
DR Ensembl; ENSBTAT00000033913; ENSBTAP00000033816; ENSBTAG00000024449.
DR GeneID; 533089; -.
DR CTD; 1063; -.
DR VGNC; VGNC:27176; CENPF.
DR eggNOG; ENOG502QVMD; Eukaryota.
DR GeneTree; ENSGT00730000111187; -.
DR HOGENOM; CLU_000551_0_0_1; -.
DR InParanoid; F1N1F8; -.
DR OrthoDB; 205405at2759; -.
DR TreeFam; TF101133; -.
DR Proteomes; UP000009136; Chromosome 16.
DR Bgee; ENSBTAG00000024449; Expressed in conceptus and 17 other tissues.
DR ExpressionAtlas; F1N1F8; baseline and differential.
DR GO; GO:0005930; C:axoneme; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR GO; GO:0097539; C:ciliary transition fiber; IEA:Ensembl.
DR GO; GO:0000940; C:condensed chromosome outer kinetochore; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0045120; C:pronucleus; IEA:Ensembl.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0051310; P:metaphase plate congression; IEA:Ensembl.
DR GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0016202; P:regulation of striated muscle tissue development; IEA:Ensembl.
DR GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR InterPro; IPR043513; Cenp-F.
DR InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR InterPro; IPR018463; Centromere_CenpF_N.
DR PANTHER; PTHR18874; PTHR18874; 3.
DR Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR Pfam; PF10473; CENP-F_leu_zip; 4.
DR Pfam; PF10481; CENP-F_N; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 1..307
FT /note="CENP-F_N"
FT /evidence="ECO:0000259|Pfam:PF10481"
FT DOMAIN 1888..2007
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2094..2233
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2276..2415
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2458..2597
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 3115..3158
FT /note="CENP-F_C_Rb_bdg"
FT /evidence="ECO:0000259|Pfam:PF10490"
FT REGION 211..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1241..1262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1712..1739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3035..3259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 13..131
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 164..191
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 280..384
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 523..706
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 725..752
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 839..873
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 899..933
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 937..989
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1036..1056
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1089..1109
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1118..1159
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1209..1229
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1283..1324
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1336..1356
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1401..1421
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1546..1616
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1789..1816
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1824..1851
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1885..1912
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1948..1992
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2000..2041
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2070..2097
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2105..2248
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2259..2279
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2287..2423
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2469..2605
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2613..2748
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2781..2829
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2834..2861
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2884..2970
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2981..3008
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 475..493
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1712..1730
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3063..3077
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3085..3099
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3100..3116
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3144..3158
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3173..3204
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3229..3244
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3259 AA; 374373 MW; BE778AEF4354384E CRC64;
MSWALEEWKE GLPTRALQKI QELEGQLDKL KKERQQRQFQ LETLEAALQK QKQKVENEKT
EGANLKRENQ SLMEICENLE KTKQKISHEL QVKESQVNFQ EGQLNSSKKQ IEKLEQELKR
CKSELERSQQ AAQSADVSLN SCLTPQKIFA TPLTPSQYYS GSKYEDLKEK YNKEVEERKR
LEAEVKALQA KKASQTIPQS TMNHRDIARH QASSSVFSWQ QEKTPSRLSS NTLKTPVRRD
FSASHFSGEQ EVTPSRSTLQ IGKTDANSSF CDNSSNSHLL DQLKAQNQEL RSKMSELELR
LQGQEKEMKG QVNKLQELQL QLEKAKVELN EKEKVLNKNR DELVRTTSQY DQASAKCTAL
EQKLKKLTED LSCQRQNAES ARCSLEQKIK EKEKEFQEEL SRQQRSFQTL DQECTQMKAR
LTQELQQAKN TYNILQAELD KVTSVKQQIE KKLEEFKQNF SKTEQALQAS QTKENELRRS
SEEMKRENSL LKSQSEQRAR EVCHLEEELK KAKQCLSQSQ NFAEEMKAKN TSQETMLRDL
QEKINQQENS LTLEKLKLAL ADLEKQRDCS QDLLKKREHH IEQLNEKLSK TERESEALLS
ALELKKKEYE ELKEEKTLFS RWKSENEQLL NQMESEKESL QSKVNHLETC LKTQQIKSHE
YNERVRTLEM ERENLNVEIR NLQNVIDSKT AEAETQKRAY GELQQKAEFS DQKHEKEIEN
MCLKISHLTG QVEDLEHKLQ LLSSEIMDKD QRYQDLHAES ESLRDLLKSR DSSAMTIEPH
QRSRLAFEQQ SALNNSFANI IGEQESVPSE RSRCHVATDQ SPKSSSMLQN RVVSLEFSLE
SQKQMNSDLQ KQCEELVQIK GEIEENLMKA EQMHQSFVAE TSQRISKLQE DTSVHQNVVA
ETLAALESKE RELQLLNEKL ETEQAETGEL KKNNHLLQES LKELQFLSET LSLEKKELNS
IISLNKKDIE ELTQENGTLK EINATLTQEK MNLLQKTESF SNCIDERDRS ISELSNQYKQ
ERLTLLQRCE ETGNAFQDLS EKYKAVQEKN SKLECLLSEC TGVCEDRKNE LGQLKETFAR
EHQAFVSQLA LAEERNQNLI VELETVQQAL QSEITDIQNS SKRETDGLKQ EIMNLKEEQN
KMQQEVSALL QENEHLMELM KTKHEHQCLE LEPIQDSEKE EREINTCHLQ LPMDLDVKDT
SPDTCNAQLV QVESKVRNME LKLQKSEKEE CLQYELQTRE LETEDLQQDP QSQDISGLGD
SEIDPEEKYI SVLQELSTSQ QDNAHLQCSL QTAMNKLNEL EKMCEALQVE KSELISELND
SRSECITATS KMAEEVGKLV NEVETLNDEN ALLQGELVEE TPEGEFGEQQ DEQTSVNLNP
LDDSNFYEHL TMSSKEVQMH FAELQEKFSS LQSEHKILHE QHCLMSSKMS ELQSYVDTLK
AENSVLSMSL RSSQGDLVKE VPPGPGEEHL LSLSFSCVTD SPGKASLGES SFYKDLLEHT
TETSLLNNLE GTVSANQSNV EEVSCSSLEE ENLTEKEIPS VPLRSARELE TLCQTYLESL
KQLEEEIESQ GITKNKEIKE LKELLSSSRE ELDDLRKQYL SENEQWQQKL TDVTAEMESK
LAAEKRHAEH LTLELEVARL QLQGLDLSSR SLLGTDIEDA ILGGNDSCDI RESEEYISET
KERTPKHEIH QICEKDVQQD LSLEMEKITK TGATKLTEEW SREQSSESSH ETPVEDPAQG
CSGCISELSL SGPNASVPRD FLENQVTIQS LELKVKETSN ENLRLLHGIE ERDQKVENLL
NEIKELDSKF HLLEVQLTTK IEACVALEKI VEELKKEKLD LNEKLESFSC HNQREESSGG
LTSNLEMVTS KFPHEGIEDD VAKVTDNWRE KCLQVENELQ RIQSEKDSME HHALSAEASL
EAVQTEKLYL EKDNENKQTV ITCLEEGLSV VTSERDQLRG ELDTLSKENQ ELDQMSEKMK
EKIRELESHQ SECLHLQEWL QSLEKDSQAL SLVRSELENQ IEQLNKEKDS LVWESESLQT
KLSESEHEKL AITKALEAAL MEKGEVAVRL SSTQEEVHQL RKGIEKLRVR IEADEKKQLH
VSEKLKESER RNDSLQDKVE TLERELQMAE ENQELVILDA ENCKAEVETL KTQIELMTER
LKDLELDLVT IRSEKENLLK QLQEKQGQAS ELDTLLSSLK NLLEEKEREK IQTKEEAKSA
VEMLQTQLRE LTEEIAALCD DQETWKVEEQ SLDSPAQEVQ QLRNNIEKLK VHLDIDKKKQ
LQILEKLKES EHQADFLKDT VENLERELKL SGENQEHVTL EAEKSKAEVE TLKATVEKMD
QNLRGLQLDL VNIRSEKEDL TKELQKEQSR VSELETLNSS FENLLREKEQ EKVQMKEESK
AAVEMLQTQL KELSEEVAIL CVDQETWKVE EQSLDSPLEE IQQLRNNIGK LKVCLDADKK
QQLHILEKLK ESEHQADFLK DTVENLEREL KLSGENQEHV TLEAEKSKAE VETLKATVEE
MDQNLRGLQL DLVNIRSDKE DLTKELQKEQ SRVSELETLN SSFENLLREK EQEKVQMKEE
SKAAVEMLQK ELEELNEKMA ALGNDQETRK VKEQSLSSQV DSLEHEKAQL LQDLDDAKSN
YMILQSSVND LIQEVEDGKQ KLEKKDEEIS ILKSQTRDQE QLVSKLSQME GEQQLWKKQK
ADLENLMVEL EQKIQVLQSK NDALQDTLEA LQNSSRNLEK ELELTKLEKM SFVEKVNTMT
VKETELQKEI HAVIQKTVAL KEEFSGEKNR LMEELNLMLE EVKSSKGQLK ELMLENSELK
KSLDCVHKDR MEEQGKMRGE IAEYQLRLQE AENKHQALLL DTNKQHEMEI QTYREKLTSK
EECLSSQKVE IDLLKSSKEE LNNSLKATTE ILEELKKTKM ENLKHADKLK KENDRAQSKI
KLLVKSCKQL EEEKVMLQKE LSHLEAAQEK QRADTVVDAN VDELITEMKE LKETLEEKTK
EADEYLDKYC SLLISHEKLE KAKEMLETQV ARLSSQQSKL NLRRSPLVNS LAPGPSPVPS
ATEKKLPSGQ NKSSGKRQRS SGIREDGGET TPSTPETFSK KSRKAIRSGT HLAEDAEDAE
FEPEGLPEVV KKGFADIPTG KTSPYILRRT TMATRTSPRL AAQKLAASPP SLDKENLTET
SKPTAGGSRS QKVKVSQQSP VDSGTAFRDP IGRSLSISNL PERSPVGSPR EGLRAKRGRH
APSPESSLES KGSENCRVQ
//
