GenomeNet

Database: UniProt
Entry: F1N1F8_BOVIN
LinkDB: F1N1F8_BOVIN
Original site: F1N1F8_BOVIN 
ID   F1N1F8_BOVIN            Unreviewed;      3259 AA.
AC   F1N1F8;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 3.
DT   10-FEB-2021, entry version 62.
DE   SubName: Full=Centromere protein F {ECO:0000313|Ensembl:ENSBTAP00000033816};
GN   Name=CENPF {ECO:0000313|Ensembl:ENSBTAP00000033816,
GN   ECO:0000313|VGNC:VGNC:27176};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000033816, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000033816}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000033816};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000033816, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000033816,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
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DR   RefSeq; XP_005217426.1; XM_005217369.3.
DR   STRING; 9913.ENSBTAP00000033816; -.
DR   PaxDb; F1N1F8; -.
DR   PRIDE; F1N1F8; -.
DR   Ensembl; ENSBTAT00000033913; ENSBTAP00000033816; ENSBTAG00000024449.
DR   GeneID; 533089; -.
DR   CTD; 1063; -.
DR   VGNC; VGNC:27176; CENPF.
DR   eggNOG; ENOG502QVMD; Eukaryota.
DR   GeneTree; ENSGT00730000111187; -.
DR   HOGENOM; CLU_000551_0_0_1; -.
DR   InParanoid; F1N1F8; -.
DR   OrthoDB; 205405at2759; -.
DR   TreeFam; TF101133; -.
DR   Proteomes; UP000009136; Chromosome 16.
DR   Bgee; ENSBTAG00000024449; Expressed in conceptus and 17 other tissues.
DR   ExpressionAtlas; F1N1F8; baseline and differential.
DR   GO; GO:0005930; C:axoneme; IEA:Ensembl.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0097539; C:ciliary transition fiber; IEA:Ensembl.
DR   GO; GO:0000940; C:condensed chromosome outer kinetochore; IEA:Ensembl.
DR   GO; GO:0030496; C:midbody; IEA:Ensembl.
DR   GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR   GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0045120; C:pronucleus; IEA:Ensembl.
DR   GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR   GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
DR   GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR   GO; GO:0051310; P:metaphase plate congression; IEA:Ensembl.
DR   GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR   GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0016202; P:regulation of striated muscle tissue development; IEA:Ensembl.
DR   GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR   InterPro; IPR043513; Cenp-F.
DR   InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR   InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR   InterPro; IPR018463; Centromere_CenpF_N.
DR   PANTHER; PTHR18874; PTHR18874; 3.
DR   Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR   Pfam; PF10473; CENP-F_leu_zip; 4.
DR   Pfam; PF10481; CENP-F_N; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT   DOMAIN          1..307
FT                   /note="CENP-F_N"
FT                   /evidence="ECO:0000259|Pfam:PF10481"
FT   DOMAIN          1888..2007
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2094..2233
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2276..2415
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2458..2597
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          3115..3158
FT                   /note="CENP-F_C_Rb_bdg"
FT                   /evidence="ECO:0000259|Pfam:PF10490"
FT   REGION          211..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          463..493
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1241..1262
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1712..1739
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3035..3259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          13..131
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          164..191
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          280..384
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          523..706
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          725..752
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          839..873
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          899..933
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          937..989
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1036..1056
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1089..1109
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1118..1159
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1209..1229
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1283..1324
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1336..1356
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1401..1421
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1546..1616
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1789..1816
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1824..1851
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1885..1912
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1948..1992
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2000..2041
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2070..2097
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2105..2248
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2259..2279
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2287..2423
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2469..2605
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2613..2748
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2781..2829
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2834..2861
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2884..2970
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2981..3008
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        475..493
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1712..1730
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3063..3077
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3085..3099
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3100..3116
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3144..3158
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3173..3204
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3229..3244
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3259 AA;  374373 MW;  BE778AEF4354384E CRC64;
     MSWALEEWKE GLPTRALQKI QELEGQLDKL KKERQQRQFQ LETLEAALQK QKQKVENEKT
     EGANLKRENQ SLMEICENLE KTKQKISHEL QVKESQVNFQ EGQLNSSKKQ IEKLEQELKR
     CKSELERSQQ AAQSADVSLN SCLTPQKIFA TPLTPSQYYS GSKYEDLKEK YNKEVEERKR
     LEAEVKALQA KKASQTIPQS TMNHRDIARH QASSSVFSWQ QEKTPSRLSS NTLKTPVRRD
     FSASHFSGEQ EVTPSRSTLQ IGKTDANSSF CDNSSNSHLL DQLKAQNQEL RSKMSELELR
     LQGQEKEMKG QVNKLQELQL QLEKAKVELN EKEKVLNKNR DELVRTTSQY DQASAKCTAL
     EQKLKKLTED LSCQRQNAES ARCSLEQKIK EKEKEFQEEL SRQQRSFQTL DQECTQMKAR
     LTQELQQAKN TYNILQAELD KVTSVKQQIE KKLEEFKQNF SKTEQALQAS QTKENELRRS
     SEEMKRENSL LKSQSEQRAR EVCHLEEELK KAKQCLSQSQ NFAEEMKAKN TSQETMLRDL
     QEKINQQENS LTLEKLKLAL ADLEKQRDCS QDLLKKREHH IEQLNEKLSK TERESEALLS
     ALELKKKEYE ELKEEKTLFS RWKSENEQLL NQMESEKESL QSKVNHLETC LKTQQIKSHE
     YNERVRTLEM ERENLNVEIR NLQNVIDSKT AEAETQKRAY GELQQKAEFS DQKHEKEIEN
     MCLKISHLTG QVEDLEHKLQ LLSSEIMDKD QRYQDLHAES ESLRDLLKSR DSSAMTIEPH
     QRSRLAFEQQ SALNNSFANI IGEQESVPSE RSRCHVATDQ SPKSSSMLQN RVVSLEFSLE
     SQKQMNSDLQ KQCEELVQIK GEIEENLMKA EQMHQSFVAE TSQRISKLQE DTSVHQNVVA
     ETLAALESKE RELQLLNEKL ETEQAETGEL KKNNHLLQES LKELQFLSET LSLEKKELNS
     IISLNKKDIE ELTQENGTLK EINATLTQEK MNLLQKTESF SNCIDERDRS ISELSNQYKQ
     ERLTLLQRCE ETGNAFQDLS EKYKAVQEKN SKLECLLSEC TGVCEDRKNE LGQLKETFAR
     EHQAFVSQLA LAEERNQNLI VELETVQQAL QSEITDIQNS SKRETDGLKQ EIMNLKEEQN
     KMQQEVSALL QENEHLMELM KTKHEHQCLE LEPIQDSEKE EREINTCHLQ LPMDLDVKDT
     SPDTCNAQLV QVESKVRNME LKLQKSEKEE CLQYELQTRE LETEDLQQDP QSQDISGLGD
     SEIDPEEKYI SVLQELSTSQ QDNAHLQCSL QTAMNKLNEL EKMCEALQVE KSELISELND
     SRSECITATS KMAEEVGKLV NEVETLNDEN ALLQGELVEE TPEGEFGEQQ DEQTSVNLNP
     LDDSNFYEHL TMSSKEVQMH FAELQEKFSS LQSEHKILHE QHCLMSSKMS ELQSYVDTLK
     AENSVLSMSL RSSQGDLVKE VPPGPGEEHL LSLSFSCVTD SPGKASLGES SFYKDLLEHT
     TETSLLNNLE GTVSANQSNV EEVSCSSLEE ENLTEKEIPS VPLRSARELE TLCQTYLESL
     KQLEEEIESQ GITKNKEIKE LKELLSSSRE ELDDLRKQYL SENEQWQQKL TDVTAEMESK
     LAAEKRHAEH LTLELEVARL QLQGLDLSSR SLLGTDIEDA ILGGNDSCDI RESEEYISET
     KERTPKHEIH QICEKDVQQD LSLEMEKITK TGATKLTEEW SREQSSESSH ETPVEDPAQG
     CSGCISELSL SGPNASVPRD FLENQVTIQS LELKVKETSN ENLRLLHGIE ERDQKVENLL
     NEIKELDSKF HLLEVQLTTK IEACVALEKI VEELKKEKLD LNEKLESFSC HNQREESSGG
     LTSNLEMVTS KFPHEGIEDD VAKVTDNWRE KCLQVENELQ RIQSEKDSME HHALSAEASL
     EAVQTEKLYL EKDNENKQTV ITCLEEGLSV VTSERDQLRG ELDTLSKENQ ELDQMSEKMK
     EKIRELESHQ SECLHLQEWL QSLEKDSQAL SLVRSELENQ IEQLNKEKDS LVWESESLQT
     KLSESEHEKL AITKALEAAL MEKGEVAVRL SSTQEEVHQL RKGIEKLRVR IEADEKKQLH
     VSEKLKESER RNDSLQDKVE TLERELQMAE ENQELVILDA ENCKAEVETL KTQIELMTER
     LKDLELDLVT IRSEKENLLK QLQEKQGQAS ELDTLLSSLK NLLEEKEREK IQTKEEAKSA
     VEMLQTQLRE LTEEIAALCD DQETWKVEEQ SLDSPAQEVQ QLRNNIEKLK VHLDIDKKKQ
     LQILEKLKES EHQADFLKDT VENLERELKL SGENQEHVTL EAEKSKAEVE TLKATVEKMD
     QNLRGLQLDL VNIRSEKEDL TKELQKEQSR VSELETLNSS FENLLREKEQ EKVQMKEESK
     AAVEMLQTQL KELSEEVAIL CVDQETWKVE EQSLDSPLEE IQQLRNNIGK LKVCLDADKK
     QQLHILEKLK ESEHQADFLK DTVENLEREL KLSGENQEHV TLEAEKSKAE VETLKATVEE
     MDQNLRGLQL DLVNIRSDKE DLTKELQKEQ SRVSELETLN SSFENLLREK EQEKVQMKEE
     SKAAVEMLQK ELEELNEKMA ALGNDQETRK VKEQSLSSQV DSLEHEKAQL LQDLDDAKSN
     YMILQSSVND LIQEVEDGKQ KLEKKDEEIS ILKSQTRDQE QLVSKLSQME GEQQLWKKQK
     ADLENLMVEL EQKIQVLQSK NDALQDTLEA LQNSSRNLEK ELELTKLEKM SFVEKVNTMT
     VKETELQKEI HAVIQKTVAL KEEFSGEKNR LMEELNLMLE EVKSSKGQLK ELMLENSELK
     KSLDCVHKDR MEEQGKMRGE IAEYQLRLQE AENKHQALLL DTNKQHEMEI QTYREKLTSK
     EECLSSQKVE IDLLKSSKEE LNNSLKATTE ILEELKKTKM ENLKHADKLK KENDRAQSKI
     KLLVKSCKQL EEEKVMLQKE LSHLEAAQEK QRADTVVDAN VDELITEMKE LKETLEEKTK
     EADEYLDKYC SLLISHEKLE KAKEMLETQV ARLSSQQSKL NLRRSPLVNS LAPGPSPVPS
     ATEKKLPSGQ NKSSGKRQRS SGIREDGGET TPSTPETFSK KSRKAIRSGT HLAEDAEDAE
     FEPEGLPEVV KKGFADIPTG KTSPYILRRT TMATRTSPRL AAQKLAASPP SLDKENLTET
     SKPTAGGSRS QKVKVSQQSP VDSGTAFRDP IGRSLSISNL PERSPVGSPR EGLRAKRGRH
     APSPESSLES KGSENCRVQ
//
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