ID   F1N2P1_BOVIN            Unreviewed;       759 AA.
AC   F1N2P1;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 3.
DT   27-MAR-2024, entry version 69.
DE   SubName: Full=RAP1 GTPase activating protein 2 {ECO:0000313|Ensembl:ENSBTAP00000026639.6};
GN   Name=RAP1GAP2 {ECO:0000313|Ensembl:ENSBTAP00000026639.6,
GN   ECO:0000313|VGNC:VGNC:33717};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000026639.6, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000026639.6, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000026639.6,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000026639.6}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000026639.6};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; F1N2P1; -.
DR   Ensembl; ENSBTAT00000026639.6; ENSBTAP00000026639.6; ENSBTAG00000020000.6.
DR   VEuPathDB; HostDB:ENSBTAG00000020000; -.
DR   VGNC; VGNC:33717; RAP1GAP2.
DR   eggNOG; KOG3686; Eukaryota.
DR   GeneTree; ENSGT00940000160935; -.
DR   HOGENOM; CLU_010739_2_2_1; -.
DR   TreeFam; TF318626; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000020000; Expressed in occipital lobe and 93 other cell types or tissues.
DR   ExpressionAtlas; F1N2P1; baseline.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 3.30.1120.160; -; 1.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR15711:SF17; RAP1 GTPASE-ACTIVATING PROTEIN 2; 1.
DR   Pfam; PF21022; Rap-GAP_dimer; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW   ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT   DOMAIN          230..446
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   REGION          491..514
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          531..759
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        557..598
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        614..632
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        641..672
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   759 AA;  83511 MW;  EA0B85786C25C8B7 CRC64;
     MFGRKRSVSF GGFGWIDKTM LASLKVKKQE LANSSDVTLP DRPLSPPLTA PPTMKSAEFF
     EMLEKMQGIK LEEQKPGPQK NKDDYIPYPS IDEVVEKGGP YPLIVLPQFG GYWIEDPENV
     STPTSLGSSI CEDEEEDSLS PSTFGYKLEC KGEARAYRRH FLGKDHLNFY CTGSSLGNLL
     LSVKCEEAEG VEYLRIILRS KVKTVHERIP LAGLSKLPSV PQIAKASQMI VSYDEHDVNN
     TFKFGVIYQK ARQTLEEELF GNNEESPAFK EFLELLGDTI TLQDFKGFRG GLDVTHGQTG
     VESVYTIFRD REIMFHVSTK LPFTEGDTQQ LQRKRHIGND IVAIIFQEEN TPFVPDMIAS
     NFLHAYIVVQ AENPGTEPPS YKVSVTARED VPAFGPPLPS PPVFQKGPEF REFLLTKLTN
     AENACCKSDK FAKLEDRTRA ALLDNLHDEL HAHTQAMLGL GPEEDKFENG GHGGFLESFK
     RAIRVRSHSM ETMVSSQKKQ HGGGIPGSLS GGITHNSVEV TKTTFSPPVA VATAKNQSRS
     PIKRRSGLFP RLHTGSEGQG DSRTRCDSAS SNPKTPEGGH SSQEIKSETS SNPSSPEICP
     NKEKPFIKLK ENGRANISRS SSSTSSFSST AGEGEAMEEC DSGSSQPSTT SPFKQEVFVY
     SPSPSSESPS LGAAATPIIM SRSPTDVKSR NSPRSNLKFR FDKLSHASSS AVRIWGRRGS
     RGSLPPPTCP SPPEARHPSW GWRKRVPHTS HGGREEALV
//