ID F1N4Y6_BOVIN Unreviewed; 720 AA.
AC F1N4Y6;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Ras GTPase-activating protein 4B {ECO:0008006|Google:ProtNLM};
GN Name=LOC521224 {ECO:0000313|Ensembl:ENSBTAP00000007169.6};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000007169.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000007169.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000007169.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000007169.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000007169.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F1N4Y6; -.
DR Ensembl; ENSBTAT00000007169.6; ENSBTAP00000007169.6; ENSBTAG00000005448.6.
DR VEuPathDB; HostDB:ENSBTAG00000005448; -.
DR eggNOG; KOG2059; Eukaryota.
DR GeneTree; ENSGT00940000160149; -.
DR HOGENOM; CLU_008096_0_0_1; -.
DR TreeFam; TF105302; -.
DR Proteomes; UP000009136; Chromosome 25.
DR Bgee; ENSBTAG00000005448; Expressed in isthmus of fallopian tube and 104 other cell types or tissues.
DR ExpressionAtlas; F1N4Y6; baseline and differential.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0071277; P:cellular response to calcium ion; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:InterPro.
DR CDD; cd04025; C2B_RasA1_RasA4; 1.
DR CDD; cd13372; PH_CAPRI; 1.
DR CDD; cd05395; RasGAP_RASA4; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR037777; RASA4_PH.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001562; Znf_Btk_motif.
DR PANTHER; PTHR10194:SF4; RAS GTPASE-ACTIVATING PROTEIN 4-RELATED; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00779; BTK; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00107; BTK; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51113; ZF_BTK; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00432}.
FT DOMAIN 44..160
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 229..439
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 493..600
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 674..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 720 AA; 80605 MW; C2903C67BC94AB42 CRC64;
MDEDALSRDD VIGKVCLTRD TLAAHPKGFS GWAHLTEVDP DEEVQGEIHL RLEVVPGTRA
CRLRCSVLEA RDLAPKDRNG ASDPFVRVRY NGRTQETSIV KKSCYPRWNE TFEFELEEGA
AEVLCVEAWD WDLVSRNDFL GKVVVNVQRL WAAQREEGWF RLQPDQSKSR REEGHLGSLQ
LEVRLRDETV LPSSCYQPLV QLLCREVKPG TQGPGQLISL IEETTSTECR QEVATTLLKL
FLGQGLAKDF LDLLFQLELS RTSEANTLFR SNSLASKSME SFLKVAGMRY LHGVLGPIID
RVFEEKKYVE LDPSKVEVKD VGCSGLHRPQ TEAEVLEQSV QTLCAHLGAL LSALSRSVRA
CPAVVRATFR QLFRRVRERF PSAQDENVPF IAVTSFLCLR FVSPAILAPK LFHLRERHAD
ARTSRTLLLL AKAVQNVGNM DTPASRAKEA WMEPLQPTVR QGVAQLKDFI TKLVDIQEKD
ELDLQRALSL QAPPVKEGPL FIHRTKGKGP LTSSSFKKLH FSLTTEALSF AKTPSSKKST
LIKLANIRAA EKVEEKSFSS SHVMQVIYTD DAGKLQTAYL QCKSVNELNQ WLSALRKVCI
NNTGLLGSYH PGIFRGDKWS CCHQRDKTDL GCNKTRSWVT LQEWNDPLDH DLEAQLIYRH
LLGVEAALRE KHRQLSTGPE AGRGPTGPGE APRDPLAELL QVLGDLQEAH RSSPAGSPPS
//
