ID F1N6E1_BOVIN Unreviewed; 384 AA.
AC F1N6E1;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 2.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Salvador family WW domain containing protein 1 {ECO:0000313|Ensembl:ENSBTAP00000002017.5};
GN Name=SAV1 {ECO:0000313|Ensembl:ENSBTAP00000002017.5,
GN ECO:0000313|VGNC:VGNC:34300};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000002017.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000002017.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000002017.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000002017.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000002017.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001178291.1; NM_001191362.1.
DR AlphaFoldDB; F1N6E1; -.
DR SMR; F1N6E1; -.
DR STRING; 9913.ENSBTAP00000002017; -.
DR PaxDb; 9913-ENSBTAP00000002017; -.
DR Ensembl; ENSBTAT00000002017.6; ENSBTAP00000002017.5; ENSBTAG00000001539.6.
DR GeneID; 516557; -.
DR KEGG; bta:516557; -.
DR CTD; 60485; -.
DR VEuPathDB; HostDB:ENSBTAG00000001539; -.
DR VGNC; VGNC:34300; SAV1.
DR eggNOG; KOG1891; Eukaryota.
DR GeneTree; ENSGT00940000156106; -.
DR HOGENOM; CLU_060422_0_0_1; -.
DR InParanoid; F1N6E1; -.
DR OMA; AARYYYP; -.
DR OrthoDB; 3673987at2759; -.
DR TreeFam; TF317631; -.
DR Reactome; R-BTA-2028269; Signaling by Hippo.
DR Proteomes; UP000009136; Chromosome 10.
DR Bgee; ENSBTAG00000001539; Expressed in myometrium and 103 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR GO; GO:0060038; P:cardiac muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0001942; P:hair follicle development; IEA:Ensembl.
DR GO; GO:0035329; P:hippo signaling; IBA:GO_Central.
DR GO; GO:0060575; P:intestinal epithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0097283; P:keratinocyte apoptotic process; IEA:Ensembl.
DR GO; GO:0030216; P:keratinocyte differentiation; IEA:Ensembl.
DR GO; GO:0060487; P:lung epithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0060044; P:negative regulation of cardiac muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IBA:GO_Central.
DR GO; GO:0045600; P:positive regulation of fat cell differentiation; IEA:Ensembl.
DR GO; GO:1902174; P:positive regulation of keratinocyte apoptotic process; IEA:Ensembl.
DR GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR GO; GO:2000036; P:regulation of stem cell population maintenance; IEA:Ensembl.
DR GO; GO:0060412; P:ventricular septum morphogenesis; IEA:Ensembl.
DR CDD; cd21433; SARAH_Sav; 1.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR InterPro; IPR011524; SARAH_dom.
DR InterPro; IPR030030; Sav.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR47522:SF2; PROTEIN SALVADOR HOMOLOG 1; 1.
DR PANTHER; PTHR47522; SALVADOR FAMILY WW DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50951; SARAH; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 200..233
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 235..268
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 322..369
FT /note="SARAH"
FT /evidence="ECO:0000259|PROSITE:PS50951"
SQ SEQUENCE 384 AA; 44709 MW; 1194E967112D2B4C CRC64;
MLSRKKTKNE VSKPAEVQGK YVKKETSPLL RNLMPSFIRH GPTIPRRTDI CLPDSGANAF
SASGDGIVSR NHSFLRTPIQ RTPHEMMRRE SNRLSAPSYL ARSLADVPRE YGSSQSFLTE
VNFAPENGDS GSRYYYSDNY FDGQRRRPLG DRAHEDYRYY EYNHDLFQRM PQNQGRHASG
IGRVAATSLG NLANHGSEDL PLPPGWSVDW TMRGRKYYID HNTNTTHWSH PLEREGLPPG
WERVESSEFG TYYVDHTNKK AQYRHPCAPS VPRYDQPPPV TYQPQQTERN QPLLVPANPY
HTAEIPDWLQ VYARAPVKYD HILKWELFQL ADLDTYQGML KLLFMKELEQ IVKMYEAYRQ
ALLTELENRK QRQQWYAQQH GKNF
//
