ID F1N6H1_BOVIN Unreviewed; 4622 AA.
AC F1N6H1;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 96.
DE SubName: Full=LDL receptor related protein 2 {ECO:0000313|Ensembl:ENSBTAP00000005988.6};
GN Name=LRP2 {ECO:0000313|Ensembl:ENSBTAP00000005988.6,
GN ECO:0000313|VGNC:VGNC:30990};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000005988.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000005988.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000005988.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000005988.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000005988.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR SMR; F1N6H1; -.
DR STRING; 9913.ENSBTAP00000005988; -.
DR PaxDb; 9913-ENSBTAP00000005988; -.
DR Ensembl; ENSBTAT00000005988.6; ENSBTAP00000005988.6; ENSBTAG00000004555.6.
DR VEuPathDB; HostDB:ENSBTAG00000004555; -.
DR VGNC; VGNC:30990; LRP2.
DR eggNOG; KOG1215; Eukaryota.
DR GeneTree; ENSGT00940000157232; -.
DR HOGENOM; CLU_000085_1_1_1; -.
DR InParanoid; F1N6H1; -.
DR OMA; RTCQPEQ; -.
DR TreeFam; TF315253; -.
DR Reactome; R-BTA-196791; Vitamin D (calciferol) metabolism.
DR Reactome; R-BTA-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR Reactome; R-BTA-8856828; Clathrin-mediated endocytosis.
DR Reactome; R-BTA-975634; Retinoid metabolism and transport.
DR Reactome; R-BTA-9758890; Transport of RCbl within the body.
DR Proteomes; UP000009136; Chromosome 2.
DR Bgee; ENSBTAG00000004555; Expressed in adult mammalian kidney and 35 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; IBA:GO_Central.
DR GO; GO:0030424; C:axon; IEA:Ensembl.
DR GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:Ensembl.
DR GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR GO; GO:0030139; C:endocytic vesicle; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005768; C:endosome; IEA:Ensembl.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0042562; F:hormone binding; IBA:GO_Central.
DR GO; GO:0051087; F:protein-folding chaperone binding; IEA:Ensembl.
DR GO; GO:0035904; P:aorta development; IEA:Ensembl.
DR GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR GO; GO:0060982; P:coronary artery morphogenesis; IEA:Ensembl.
DR GO; GO:0034311; P:diol metabolic process; IEA:Ensembl.
DR GO; GO:1904447; P:folate import across plasma membrane; IEA:Ensembl.
DR GO; GO:0030900; P:forebrain development; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0008584; P:male gonad development; IEA:Ensembl.
DR GO; GO:0030001; P:metal ion transport; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
DR GO; GO:0140058; P:neuron projection arborization; IEA:Ensembl.
DR GO; GO:0003148; P:outflow tract septum morphogenesis; IEA:Ensembl.
DR GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0070447; P:positive regulation of oligodendrocyte progenitor proliferation; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR GO; GO:0061156; P:pulmonary artery morphogenesis; IEA:Ensembl.
DR GO; GO:0006898; P:receptor-mediated endocytosis; IBA:GO_Central.
DR GO; GO:0044321; P:response to leptin; IEA:Ensembl.
DR GO; GO:0003139; P:secondary heart field specification; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR GO; GO:0060068; P:vagina development; IEA:Ensembl.
DR GO; GO:0003223; P:ventricular compact myocardium morphogenesis; IEA:Ensembl.
DR GO; GO:0003281; P:ventricular septum development; IEA:Ensembl.
DR GO; GO:0042359; P:vitamin D metabolic process; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00112; LDLa; 35.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 36.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 8.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR019825; Lectin_legB_Mn/Ca_BS.
DR PANTHER; PTHR22722:SF11; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2; 1.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00057; Ldl_recept_a; 35.
DR Pfam; PF00058; Ldl_recept_b; 12.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 22.
DR SMART; SM00179; EGF_CA; 12.
DR SMART; SM00192; LDLa; 36.
DR SMART; SM00135; LY; 38.
DR SUPFAM; SSF57196; EGF/Laminin; 8.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 35.
DR SUPFAM; SSF63825; YWTD domain; 8.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS01209; LDLRA_1; 13.
DR PROSITE; PS50068; LDLRA_2; 36.
DR PROSITE; PS51120; LDLRB; 21.
DR PROSITE; PS00307; LECTIN_LEGUME_BETA; 1.
PE 1: Evidence at protein level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1N6H1};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 4394..4415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 410..452
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 453..495
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 496..542
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 543..585
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 727..769
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 770..811
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 856..899
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1454..1496
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1497..1539
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1542..1585
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1856..1903
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1904..1945
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2173..2216
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2490..2533
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2534..2575
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3208..3250
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3302..3345
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3346..3389
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 4124..4166
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 4167..4210
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 4212..4253
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 4347..4381
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 4560..4622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1..13
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 8..26
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 20..35
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 81..93
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 88..106
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 100..115
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 125..143
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 137..152
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 156..168
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 163..181
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 175..190
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 196..208
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 203..221
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 215..230
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 999..1011
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1006..1024
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1018..1033
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1060..1075
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1083..1095
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1090..1108
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1102..1117
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1123..1135
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1130..1148
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1142..1157
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1181..1196
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1245..1257
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1252..1270
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1264..1279
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2670..2682
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2677..2695
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2711..2723
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2718..2736
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2730..2745
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2750..2762
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2757..2775
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2833..2845
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2840..2858
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2875..2887
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2882..2900
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2962..2974
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2969..2987
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2981..2996
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3001..3013
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3008..3026
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3044..3056
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3051..3069
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3063..3078
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3523..3535
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3530..3548
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3564..3576
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3571..3589
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3605..3617
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3612..3630
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3669..3684
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3697..3715
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3709..3724
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3729..3741
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3736..3754
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3748..3763
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3768..3780
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3775..3793
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3787..3802
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3812..3824
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3819..3837
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3861..3879
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3898..3910
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3905..3923
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3917..3932
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 4371..4380
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4622 AA; 517231 MW; 16B834ABB36F7CEB CRC64;
CRSNEFLCQP GLCITASWRC DGTRDCPNGA DEIDCPTSSC HSNQFLCPNE QLCIPESWVC
DGEDDCNDGA DERRHCPGIT CSSRQFTCEN GECIPGEFRC DHSTDCLDGT DEKNCRYPVC
EQLTCADGAC YNTSQRCNGQ VDCRDASDER NCTHRCTRTE FQCGSGQCIP RTYVCDHEID
CEDGSDEHSC PAYRTCKGNE FTCPNGVCIA QSWVCDGESD CVDNADEDGC ESKINRTFEC
YPNEWACPKS GKCIPISKVC DGTLDCPGGE DESNITAGQQ CDVNLCPSLG CEYQCHRSPG
GGMCYCPSGF IVNQNRTNNC VDFDDCQIWG VCDQLCEDRI GHHRCNCVEG YVLERQKHCR
ANSSFGEAFV IFSNGRNLLK GSIRGNNFQI LAESQNRGLA VGVDFHYRLR RVFWTDIVQK
KVFSVDISGS RIREVLGVSI EDPENLAVDW VNNKLYIVET RVNCIDVVDL DGSHRITLIS
EYLGHPRGIA VDPTVGYLFF SDWQNVFGVP RIERAYMDGS NRKDLVTTKL GWPGGITLDL
VSKRVYWVDS RFDYIETVTY DGLKRMTVIH GGADIPHPFS ISLFEGQLFF TDWTKMAVLK
ANKFKETNPR LYYRSSLKPF GVTVYHGLRQ PYARNPCAHE NGGCQHICVL SHRTFNGGLG
YRCKCRLGYI PDWDDYHCVA AERFLLFSSN LAVRGIPLTL SHQTEVILPV TGSSSIFLGI
DFDAREKAIF FSDTKKNIIY RQKLDGTGRE IITANRVPAV QSLSFDWISR NLYWTDSSYR
SVSVIRLGDK SRRTIIQNLN NPQSIVVHPT AGYIFFSVWY RPAKILRAWA DGSNILPIVN
TTLGWPSGLS IDWSSSRLYW VDAFFDKIEH SNLDGSDRKA LTNVHQLTHP FGLAVSQDYI
YVTDWRRGII RFGKYNPGQS IILRSGVGSV MRAKVYDSRV QTGSNACSRP TNPNGDCSHF
CFPVPNSQRV CGCPYGMSLA SDHLTCVENA SREPPVEQCG TLSFSCHNGR CVPLQYRCDG
FDDCLDNSDE AQCTTSNATC SPLAFECKRE GHCIPSMWRC DGEDDCLDGS DEQNCPTRAP
TSCRADQFTC DNNFCIPRSW VCDTDNDCKD GSDEKSCNYT QTCSPTQFHC PDHRCIALTF
VCDGTKDCAD GSDEIGCVIN CTASQFTCVS NGQCISKTYR CDGVFDCDDH SDETDCPTRP
PGMCHQDEFQ CQEDGICIPK TWECDGHEDC LQGSDEHNGC PPKTCHPSHF VCQNGNCIYR
NWLCDGDNDC GDMSDEKDCP TQPFQCPSWQ WQCPGHSICV NLSAVCDGVS DCPGGTDESP
LCNQNSCSDS NGGCTHQCIQ GPYGAQCQCP LGYLLGNDSK TCEDIDECRT PGFCSQYCYN
MRGSFRCWCD SEYTLDADRR TCKATGNEKS ETLLLVASQS QLVAGNMTQN GYFVYPVIQH
GSHIVAVDFD SVSGRIFWSD GTQGKIWSAF QNGTDKKLIL DSGVSMTGSI AVDWIGRNLY
WTDISLRTID VAKLDGSHKT VLISENITNL GGLAVDPRAT DRVMFWSDWG SHPRIERASM
DGSQRTIIVQ EKIYWPNGLA LDYPNRLLYF MDGYLDYLDF CHYDGSNRRQ VIASDLILRH
PYSISLFEDT VYWSDRATHE VMKANKWHGG NQSVVMTLHQ PLGIVVVHPA KQPVSSNPCS
YTRCSHLCLL SSKSLYSCAC PSGWTLARDS VTCVRDDQAF LIVVRNSIIF GISLNPDVKT
FDGMVPISGI RNGYDVAVDY SEQFIYWLEN PGEIHRVKTD GTNRTVFAPL SSLGASASLA
LDWLSRNLYF TDHVTRSIKV MTLQGDVSYR KTLIANDGTS LGVGLPVGIT IDPINGKLYW
SDRGTNSGLP PKIASANMDG KSPRTLFTGS LENVAFITLD IEEQKLYWAV SSTGVIERGN
VDGTNRMILV NHLSYPWGLA VHGRFLYYSD EEYEVIERVD KATGANKVVL RNNLPDLRGL
KIYQRRSESS NGCSNNMNAC QQICLPVPGR LFSCACATGF KLNPDHQTCS PYNSFIVVST
LRTIRGFSLQ LSDHSEAMVP VAGPGRNALH VDVDVSSGFI YWCDFNISVA SNNAIRRIKP
DGSNFTNIVT DGIGVNGVRG IAVDWVAGNL YFTNAFRSET LIEVLRINTT HRHILLKTIV
DMPRDIVVDP KNRYLFWSDY GQNPKIERSF LDCTNRTVLV SDITATPRGL ALDHSSNYIY
WVDDAVDLIA RISIEGGETE VIRFGSHYPA PYAITVFGNS IIWVDRNLKK ILQASKEPNR
ADRPTVIRDN IDWLRDVTIF DQSVQPRSPA EVNNNPCLEN NGGCAQFCFA LPKSQTPKCD
CAFGTLQADG KSCAISSENF LIFALDDSLR SLRFDPKDYS QPFPAISVER MAVALDYDSI
DNRIYFTQLL PSGKGQISYI NLNSRSSPPT VVVSGIGSPE GIAFDWINKR IYYSDYTNQM
IKSIATDGSR HTLIAQVPKP RGIVLDPCQG YMYWTDWGTN AKIEMATMGG YSRRSLVDRG
LVWPNGLTLD YEQNLIYWAD ANLEKIERMD LEHYLREVIV SRANSPFGLA IYGQYVYWTD
LLTQKIYRAN KVDGSGQTAV TVTLPFRPKG IRAVVKDQQQ CLSPCDRFNG GCSHICAPGP
NGAECQCPHE GRWYLANNNK YCIQDNGTRC DSSKFTCLSG KCIPDQLQCN DIDDCGDSSD
ELETLCAFHS CPSTSFTCAN GRCVPYSDRC DHYNDCGDNS DEAGCHFRAC NRTEFTCSNG
RCIPSELVCD GVDNCLDNSA SDEKNCPERT CHTGYVKCTN STICIPRSFL CDGDNDCGDM
SDENPLFCAT RSCGSDEFHC TSGPCIPARW YCDHEKDCSD GSDEPPTCEF SQSTCASDYF
KCDNNRCIPM MWVCDGDNDC GDMSDEDERH NCKNRNCSSS EFACEVGVRP HRGCIPKSWV
CDGEADCLDA LDEHQNCTRR SCFGTEFVCN NGLCIPNHFR CDRNNDCGDY SDERGCVYPT
CDETLFTCQN GLCINKAYVC DGDNDCKDNS DELEHLCHTP ETTCPPHQFR CDNGNCIEMM
KVCNNFPDCS DNSDEKGCGI NECNDPTLSG CNQNCTDTLT SFYCSCNPGY KLLSDKRTCV
DIDECEETPF VCSQKCENLP GTYICKCAPG YIREPDGKTC RQNSNIEPDL IFSNRYYLRN
LTVYGHLYSL ILQGLGNVVA LDFDRVEKRL YWLDIENKVI ERMFVNTTNR ETVLKYNLPG
AESLAVDWVT RKLYWVDSYL NCLSVSDLNG RYRRKLAEHC VDANNTFCFE NPRGLALHPR
YGHVYWADWG DRAYIGRVGM DGTLKSLIIS TKIMWPNGLT IDYTNDLLYW ADAHLGYIEF
SDLEGRHRHT VYETGTLSHP FAITIFEDTI YWTDWNTKTV EKGNKYNGSD RVALLNVTHR
PYDIRVYHPY RQPIVPNPCG TNNGGCSHLC LIKEGGVGFT CECPDNFYTV QRGPNTQCLP
MCSSTQFLCA DSEMCIPIWW KCDGRRDCLD GSDEPITCPQ RFCALGMFQC NDGNCTNSHS
LCNLRQDCPD GSDEDPVLCE HHQCEPYEWQ CANKRCIPES WQCDMQDDCD DNSDEDSSHC
ASRTCRPGYF KCANGHCIPQ IWKCDVDNDC GDYSDEPLQE CLGPSYRCDN YTEFSCKTNY
RCIPKWAVCN GVDDCRDNSD EQDCESMTCK PSGEFRCTNH RCIPLRWRCD GQNDCGDRSD
EENCAPRKCT ESEFRCDDQS CIPSRWVCDQ TNDCGDNSDE RDCEMMTCRP GYFQCDSGHC
ISEHMKCNGV ADCRDASDEA NCPTRFPNGA YCPATMFECK NHVCIHSSWK CDGDNDCGDG
SDEELHLCLN VACDSPYRFR CDNNRCIYRH EVCNQEDDCG DGSDEKKELC VEPTPRPCTP
DEFKCSNGRC IPQHRVCDHV NDCGDNFDET GCNTGKDRSC AENLCEHNCT QLREGGFICS
CRPGFKPNSI DRNLCEDINE CMQFGSCPQI CHNTKGSYEC SCAEGFTSLS DRYGERCAAD
GSPPLLLLPE NVRIRKYNLS SLQFSEYLED QERIKAMDYD WDPEGTGLSV VYYTVLGEGS
NSGAIKRAYI PNFESGSNNP VMEINLDLKY IVQPDGLAVD WVGRHIYWSD ARRQRIEVAE
LDGRYRKWLI STELGQPAAI VVNPKLGFMY WTDWGENPKI ESAWMDGQRR KVLVQEDLGW
PTGLCIDYMN GDRIYWSDLK DNIVETIKYD GTDRRIVVTS AVNPYSLDIF ESQLYWTSKD
KGEVWIQDKF GRNKKEKLLT VNPWLTQVRV FHQRKYNHSV PNRCKDVCSH LCLLRPKGYT
CACPQGSRFL EGSVTVCDAA IVGAVSMPPP CRCMNRGSCY FDENNLPKCK CSSGYVGEYC
EMGLSQGVPP GTTASVLLTV ILIVIIAALA TLGFLHYRKT GSILPSLPKL SSLSHLKSSE
NGNGVTFRSG DDVNMDIGVT GFGPESAIDR SLAMNEHFAA DFGKSPIIFE NPTYSSKDTA
ITVAQPTTAP VTESATVYNK NYGSPINPAE LVTDTKPTSS SDETQPTKWN IFKRKPKQNT
NFENPFYSEM ENEPKVGAAV TPPPSPSPPA KVSWKKGSTP GYSATEDTFK DTANLVREDS
EA
//
