ID F1N6I8_BOVIN Unreviewed; 1898 AA.
AC F1N6I8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Bromodomain adjacent to zinc finger domain 2A {ECO:0000313|Ensembl:ENSBTAP00000038030.5};
GN Name=BAZ2A {ECO:0000313|Ensembl:ENSBTAP00000038030.5,
GN ECO:0000313|VGNC:VGNC:26430};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000038030.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000038030.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000038030.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000038030.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000038030.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WAL family. {ECO:0000256|ARBA:ARBA00007444}.
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DR RefSeq; NP_001180159.2; NM_001193230.2.
DR SMR; F1N6I8; -.
DR STRING; 9913.ENSBTAP00000038030; -.
DR PaxDb; 9913-ENSBTAP00000038030; -.
DR Ensembl; ENSBTAT00000038215.5; ENSBTAP00000038030.5; ENSBTAG00000017840.6.
DR GeneID; 509799; -.
DR KEGG; bta:509799; -.
DR CTD; 11176; -.
DR VEuPathDB; HostDB:ENSBTAG00000017840; -.
DR VGNC; VGNC:26430; BAZ2A.
DR eggNOG; KOG1245; Eukaryota.
DR GeneTree; ENSGT00940000159490; -.
DR HOGENOM; CLU_000899_1_0_1; -.
DR InParanoid; F1N6I8; -.
DR OMA; GMIMWER; -.
DR TreeFam; TF329083; -.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000017840; Expressed in thymus and 106 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0033553; C:rDNA heterochromatin; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd05503; Bromo_BAZ2A_B_like; 1.
DR CDD; cd01397; HAT_MBD; 1.
DR CDD; cd15629; PHD_BAZ2A; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR017956; AT_hook_DNA-bd_motif.
DR InterPro; IPR037374; BAZ2A/B_Bromo.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR028940; PHD_BAZ2A.
DR InterPro; IPR028942; WHIM1_dom.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45915:SF5; BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2A; 1.
DR PANTHER; PTHR45915; TRANSCRIPTION INTERMEDIARY FACTOR; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF15612; WHIM1; 1.
DR Pfam; PF15613; WSD; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00384; AT_hook; 4.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 538..609
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 840..905
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 1670..1720
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1803..1873
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 642..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 709..770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1016..1065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1149..1256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1277..1406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1755..1782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 645..668
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..770
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1016..1042
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1149..1178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1181..1195
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1204..1237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1312..1326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1340..1368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1898 AA; 210125 MW; 6FA60EEF9DD94F80 CRC64;
MKMEANDHFN FTGLPPAPAA SGLKPSPSSG EGLYTNGSPM NFPQQGKSLN GDVNVNGLST
VSHTTTSGIL NSAPHSSSTS HLHHPNVAYD CLWNYSQYPS ANPGSNLKDP PLLSQFSGGQ
YPLNGILGGS RQPSSPSHNT NLRAGSQEFW ANGTQSPMGL NFDSQELYDS FPDQNFEVMP
NGPPSFFTSP QTSPMLGSSI QTFAPSQEVG SGIHPDEAAE KELTSVVTEN GAGLVGSLEL
EEEQPELKMC GYNGSVPSVE SLHQEVSVLV PDPTVSCLDD PSHLPDQLED TPILSEVSLE
PFNTLAPEPV SGGLYGIDDT ELMGAEDKLP LEDSPVISAL DCPSLNNATA FSLLADDSQT
SASIFASPTS PPVLGESVLQ DNSFDLNNGS DAEQEEMETQ ASDFPPLTQP APDQSSTIQL
HPATSPAVSP TASSAVSLPV SPAASPEISP AISPAAFPEV SPASSAALPP VSSEVSLTAS
PVTSPKASPA ASPAAVFPTV SPADKDISSV PETIADLEDT TVEGVPPSGS GDVLRRRIAT
PEEVRLPLQH GWRREVRIKK GSHRWQGETW YYGPCGKRMK QFPEVIKYLS RNVVHNVRRE
HFSFSPRMPV GDFFEERDTP EGLQWVQLSA EEIPSRIQAI TGKRGRPRNT EKAKTKEVPK
VKRGRGRPPK VKITELLNKT DTRLLKKLEA QETLNEEDKA KMCKIKKKIK QKVQRGECQT
TNQGQAKNKR KQETKSLKQK EAKKKSKAEK EKVKTKQEKL KEKVKREKKE KVKMKEKEEV
AKTKPTGKAD KVLATQRRLE ERQRQQMILE EMKKPTEDMC LTDHQPLPDF SRIPGLILPS
GAFSDCLTIV EFLHSFGKVL GFDPAKDVPS LGVLQEGLLC QGDSLGEVQD LLVRLLRAAL
CDPGLPSYCQ SLKILGEKVS EIPLTRDNVS EILRCFLMAY GVEPALCDSL RTQPFQAQPP
QQKAAVLAFL VHELNGSTLI INEIDKTLES MSSYRKNKWI VEGRLRRLKT ALAKRTGRPE
VELQGPEEGL GRRRSSRIME ETSGMEEEEE EETAAAVHGR RGRRDGEVDI TASSIPELER
QIEKLSKRQL FFRKKLLHSS QMLRAVSLGQ DRYRRRYWVL PYLTGIFVEG TEGSLVPEDV
IKQETDSLKV ATHSTTSPTS FSLKRELAGS STSASSPARA RGRPRKTKPG SMQPRHLKSH
SKGQGSEEPQ TQLQPETQSH PQLQAHAQPQ LQSHPHTHNG FLEPEGSPLS LGQSQHDLSQ
SAFLSWLSQT QNHGSLLSSS VLTPDSSPGK LDPAPSHAPE EPEPDETEAS PDSQAPWFNF
SAQMPCNAAP TPPPAVSEDQ PTLSPQLPAS SKPVSRASAA NAYSPGPFSS TPLLGMAHKR
QAGDPGETPQ SPTGQGQPKR RGRPPSKFFK QMEQRYLTQL TAQPVPPEMR SGWWWIRDPE
TLDATLKALH PRGIREKALH KHLNKHRDFL QEVCLRPSTD PIFEPSQLPA FEEGIVSWTP
KEKTYETDLA VLQWVEELEQ RVILSDLQIR GWTCPSPDST REDLAYCEHL ADSQEDITWR
GRGKEGLAPQ RKTTNPLDLA VMRLAALEQN VERRYLREPL WPAHEVVLEK ALLSTPSSAP
QCTPTEISYE ITPRVRAWRQ TLERCRSAAQ VCLCLGQLER SIAWEKSVNK VTCLVCRKGD
NDEFLLLCDG CDRGCHIYCL RPKMEAVPEG DWFCAVCLAQ QVEGELTQKS GFPKRGQKRK
SGYVLTFPEG DNRRRRLLPR GRESPAVPRY SEEGLSPSKR RRVSMRNHHS DLTFCEIILM
EMESHDAAWP FLEPVNPRLV SGYRRIIKNP MDFSTMRERL LRGGYTSSEE FAADALLVFD
NCQTFNEDDS EVGKAGHIMR RFFESRWEEF YQGKQANL
//
