ID F1N740_BOVIN Unreviewed; 3979 AA.
AC F1N740;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Fraser extracellular matrix complex subunit 1 {ECO:0000313|Ensembl:ENSBTAP00000053681.3};
GN Name=FRAS1 {ECO:0000313|Ensembl:ENSBTAP00000053681.3,
GN ECO:0000313|VGNC:VGNC:59334};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000053681.3, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000053681.3, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000053681.3,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000053681.3}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000053681.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FRAS1 family.
CC {ECO:0000256|ARBA:ARBA00005529}.
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DR STRING; 9913.ENSBTAP00000053681; -.
DR PaxDb; 9913-ENSBTAP00000053681; -.
DR Ensembl; ENSBTAT00000060947.3; ENSBTAP00000053681.3; ENSBTAG00000010716.7.
DR VEuPathDB; HostDB:ENSBTAG00000010716; -.
DR VGNC; VGNC:59334; FRAS1.
DR eggNOG; KOG1216; Eukaryota.
DR eggNOG; KOG1306; Eukaryota.
DR eggNOG; KOG3525; Eukaryota.
DR eggNOG; KOG3597; Eukaryota.
DR GeneTree; ENSGT00940000162130; -.
DR HOGENOM; CLU_000244_0_0_1; -.
DR InParanoid; F1N740; -.
DR OMA; NSGMRVQ; -.
DR TreeFam; TF316876; -.
DR Proteomes; UP000009136; Chromosome 6.
DR Bgee; ENSBTAG00000010716; Expressed in semen and 42 other cell types or tissues.
DR ExpressionAtlas; F1N740; baseline.
DR GO; GO:0005604; C:basement membrane; IEA:Ensembl.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
DR GO; GO:0003338; P:metanephros morphogenesis; IEA:Ensembl.
DR GO; GO:0002009; P:morphogenesis of an epithelium; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR GO; GO:0060021; P:roof of mouth development; IEA:Ensembl.
DR GO; GO:0043588; P:skin development; IEA:Ensembl.
DR CDD; cd00064; FU; 11.
DR Gene3D; 2.60.40.2030; -; 5.
DR Gene3D; 6.20.200.20; -; 3.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR45739:SF1; EXTRACELLULAR MATRIX ORGANIZING PROTEIN FRAS1; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 12.
DR Pfam; PF03160; Calx-beta; 5.
DR Pfam; PF00093; VWC; 3.
DR SMART; SM00237; Calx_beta; 5.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00261; FU; 14.
DR SMART; SM00214; VWC; 6.
DR SMART; SM00215; VWC_out; 3.
DR SUPFAM; SSF141072; CalX-like; 5.
DR SUPFAM; SSF57603; FnI-like domain; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR PROSITE; PS51854; CSPG; 12.
DR PROSITE; PS01208; VWFC_1; 2.
DR PROSITE; PS50184; VWFC_2; 5.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3873..3893
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 21..73
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 78..138
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 189..249
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 253..313
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 317..387
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REPEAT 1072..1167
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1187..1278
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1299..1408
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1432..1530
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1563..1658
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1679..1777
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1800..1903
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1924..2024
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2045..2144
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2166..2258
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2278..2371
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2406..2503
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
SQ SEQUENCE 3979 AA; 439367 MW; 7A4BD6444B4B5712 CRC64;
LGVLTGWSGQ GNRNLAYASL QDATIWKPDS CQNCRCHGDI VICKPAVCRN PQCAFEKGEV
LQIPANQCCP ECVPRMPGSC HYEKKIHGHG TAWASSPCST CSCTHGEVRC APQPCPPLMC
GHQELEFIPE GSCCPVCVGP GKSCSYEGHC VCRNGVAQCF AAQCPPLFCN QDETVIRVPG
KCCPQCSSLS CSAAGQVYEH GEQWQENACT TCTCDQGQVR CHKQPCPPLR CEKGQRRARL
PGQCCEDCVS PAGSCSHRGL VRYQDDMWKG SACEFCVCNR GQVTCQTAEC AKVECAQGEE
LIHLEGKCCP ECISRNGYCV YEENAEFMSS NASKVKRIPE GEKWEDGPCK VCECRGAQIT
CYEPSCPPCP VATLAQAVKG QCCPDCTSVR CHPDCLTCSQ SPDHCDLCQD PTKLLRNGQC
VHSCGLGFYQ AGALCLACQP QCSTCTSGLE CSSCQPPLLM QQGQCVSTCG IGFYQDRHSC
AACHESCAAC WGPTEKHCLA CRDPLHVLRE GGCESSCGNR FYNKQGTCSA CDQSCKSCGP
SSPRCLTCVE KTVLHDGKCI SECPGGYYAD ATGRCKVCHN SCASCSGPTA AHCTACIHPQ
ALRQGHCLPN CGEAFYPDHG VCKACHTSCL TCVGPAHSHC TQCRKPEDGL QFEPLSGANI
TSGECLSRCR AQFYLEITGL CEACHPSCSA CAGMSPHNCT ACWPSHMLLD GECLSQCPDG
YFNQEGSCTE CHPTCRQCHG PLESDCISCH PHVPLTAGSC RARCKEEQFL NLVGYCADCH
PLCHHCAANL RDTGSVCLRC QNARNLLLGD RCVPDCPSGY FVERGACKKC HSSCRTCQGR
GPFSCSSCDT GRVLSHLGTC SIACFPGHYL DDNRVCQPCN MHCGRCDSQA SCTSCRDPSK
VLLFGDCQHE SCAPQYYLDF STKTCKECDW SCNVCSGPLR TDCLQCMDGY VLQDGACVEQ
CSASFYRDLG LCKSCESHCL QCQGPHECTR CEEPFLLLEA QCVQECGKGF FADHANHKCT
ACPKGCLQCS RRDRCHLCDQ GFFLKSGLCL SNCVPGFSAH SSNETCAGKI HTPSLHVNGS
LTLAIGSMKP LDFFLLNVQD QGGRVEDLLF HVVSAPTNGQ LVLSRNGKEA QLDKAGHFSW
RDVKEKKVRF VHSREKPRKG YFSLKISDQQ FFSEPQLINI QAFSTQAPYV LRNEVLHINR
GERGTITTQL LDIRDDDNPQ DVVVEVLDPP LHGQLLQTLQ SPAAPIYQFR LDELSRGLVQ
YVHDGSDSTS DITVLQANDG HSFQNILFHV RTVPKNDRGL RLVANSMVWV PEGGMLQITN
RILQAEAPGA SASEIIYKIT QDHPQFGEVV LLVNMPADSP ADGGQHLPDG RTATPTSTFT
QQDINEGIVW YRHSGVPAQS DSFRFQVSSA TEAHTHLESR LFNIAILPHA LETPQHFPGS
LHMTAREDGL TVIQPHSLSF VNSERPNRKL IYNITLPLHP NQGIIEHRDQ PHSPIRYFSQ
EDVNQGNIMY RPPTAAPHLQ EIRAFSFAGL PESVKFHFTV SDGEHTSPEM ALTIHLLRTD
QYPPVFQVTA PLLVVSPGGS TSIELQLVVR DMETVPEELL FELRKPPQHG VLIKYTAGSP
GPMATGDTFT YEDVEKNVLR YLHDGSSARE DSMEISVTDG LSATTVDVRV EVSPAEAQGP
RLAAGASLSV TVASKSTAVI TRSHLAYVDD SSSDPEIWIQ ITSLPMYGAL LKTAGPEVEE
LSEISNFTME DINNKKISVA HSFHSSLDFY SFHFSVSDMD HNRLDNQKFT ITITPVKDPP
PVIAFADLIT VDEGGRTPLS FHHFFAAAAE DSFQEDAIIK LSALPQYGCI ENTGTGDRFG
PGTTSDLEAS FPIQDVLENY IYYFQSVHES IEPTHDIFSF YVSDGNSRSE VHSINITIER
KNDEPPRMTL RPLGVQLSSG VVISNSSLSL QDLDTPDNEL IFVLTKKPGH GHLLWRQTAS
EPLENGRVLA QGSSFTYQDI LAGLVGYMPG GPGVAVDEFQ FSLTDGLHTD TGRMEIYIEL
PTSDIPNLAV NRGLQVSAGS VATITDWHLK VTAPDSDDHQ VMYILKEDPG VGRLQMVKRD
SLEQISTRGP IQSFTQADIS QGLIEYSHGK GESGGNFAFK FDVVDGEGNK LIGQSFSISV
SEDKSPPVII TNKGLFLDEN SVKKITTLQL SATDQEAEPT ELVYRIIREP QLGRLEHTAS
PGIQISSFTQ ADLTSGNVQY IHSSETEKHS DAFSFTLSDG VHEVTQTFRI TLRPVDDSLP
HVQNFGMRVQ EGVRKTITEF ELKAVDEDTE AESVTFTVVQ PPRHGTIERT ADGQPFQLMS
TFTMEDIYQS RVRYSHDGSN SLRDRFTFTV ADGTNPFFIV EEGGKEIITA APQQFWIDIL
PVDDGTPRIV TNLGLQWLEY MDGQATNLIT KKELLTMDPD TEDLQLVYEI TTGPKHGHVE
NKLQPGRAVA TFTQEDVNLG LIRYVLHEEK IHEMMDSFQF LVKDSKPNVV NDNIFHIQWS
LISFKYTSYN VSEKAGSVSV TVQRTGNLNQ YAIVLCRTEQ GTATSSSRVG SQPGQQDYVE
YAGQVQFDER EDTKSCTIVI NDDNVFEDVE SFTVELSMPA YALLGEFTQA KVIINDTEDE
PTLEFDKKTY RVNESAGFLF APIERKGDSS SIVSVICYTV PKSAMGSSLY ALESGSDFKS
RGMSAESRVI FGPGVTMSTC DVMLIDDSEY EEEEEFEIAL TGASDNARIG RMASAKVLIA
GPNDASTVSL GNTAFTISED AGTVKIPVIR HGTDLSTFTS VWCATRPSDP ASATPGVDYV
PSSRKVEFGP GVTEQYCTLT ILDDTQYPVI EGLETFVVFL SSPQGAELTK PFQAVIAIND
TFQDVPSMQF AKDLLLVKEK EGVLHVPIIR SGDLSYESSV RCYTQGLSAQ VMEDFEERRN
ADSSRITFLK GEKMKNCTVY IHDDSMFEPE EQFRVYLGRP LGNHWSGARV GKNHMATITI
SNDEDAPTIE FEEAAYQVRE PSGPDATAIL NVKVIRRGDQ NRTSKIRCST RDGSAQSGVD
YYPKSRVLKF SPGVDHIFFK VEILSNEDRE WHESFSLVLG PDDPVEAVLG DVTTATVTIL
DQEAAGSLIL PAPPIVVTLA DYDHVEEVTK EGVKKSPSPG YPLICVTPCD PHFPKYAVMK
ERCIEAGINQ TSVQFSWEVA APTDGNGARS PFETITDNTP FTSVNHMVLD SIYFSRRFHV
RCVAKAVDKV GHVGTPLRSN VVTIGTDSAI CHTPVVAGTA RGFQAQSFIA TLKYLDVKHK
EHPNRIHISV QIPHQDGMLP LISTMPLHNL HFLLSESIYR HQHVCSNLVT TRDLRGISEA
GFLDDRVHDS MALGPGYDRP FQFDSSVREP KTIQLYKHLN LKSCVWTFDA YYDMTELIDV
CGGSVTADFQ VRDSAQSFLT VHVPLHVSYI YVTAPRGWAS LEHHTEMEFS FFYDTVLWRT
GIQTDSVLSA RLQIIRIYIR EDGRLVIEFK THAKFRGQFV MEHHTLPDVK SFILTPDHLG
GIEFDLQLLW SAQTFDSPYQ LWRATSSYNR KDYSGEYTIY LIPCTVQPTQ PWADPGEKPL
ACTAHAPERF LIPIAFQQTN RPVPVVYSLN TEFQLCNNEK VFLMDPNTSD MSLAEMDYKG
AFSKGQILYG RVLWNPEQNL NSAYKLQLEK VYLCTGKDGY VPFFDPTGTI YNEGPQYGCI
QPNKHLKHRF LLLDRSQPEV TDKYFHDVPF EAHFASELPD FHVVSSMPGV DGFTLKVDAL
YKVEAGHQWY LQVIYIIGPD TISGPRVQRS LTAPLRRHRR DLADPSGWLS LDESLIYDNE
GDQVKNGTNM KSLNLEMQEP VVAASLSQTG ASIGSALAAI MLLLLVSLVA CFITRKCQKQ
RKKPPTGDIL EEYPLNTKVD MPKRGADRVE KNVDRQYCTV RNVNILGEAE RAYVFRGAKV
KKLNLEVRVH NNLQDGTEV
//
