ID F1N7K4_BOVIN Unreviewed; 239 AA.
AC F1N7K4;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Nucleolar protein of 40 kDa {ECO:0008006|Google:ProtNLM};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000048530.3, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000048530.3, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000048530.3,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000048530.3}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000048530.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F1N7K4; -.
DR SMR; F1N7K4; -.
DR STRING; 9913.ENSBTAP00000048530; -.
DR PaxDb; 9913-ENSBTAP00000048530; -.
DR Ensembl; ENSBTAT00000001878.6; ENSBTAP00000048530.3; ENSBTAG00000001432.6.
DR VEuPathDB; HostDB:ENSBTAG00000001432; -.
DR eggNOG; KOG0922; Eukaryota.
DR GeneTree; ENSGT00510000047363; -.
DR HOGENOM; CLU_068074_0_0_1; -.
DR InParanoid; F1N7K4; -.
DR OMA; EERMSEP; -.
DR TreeFam; TF332136; -.
DR Proteomes; UP000009136; Chromosome 15.
DR Bgee; ENSBTAG00000001432; Expressed in semen and 7 other cell types or tissues.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0031090; C:organelle membrane; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0043489; P:RNA stabilization; IBA:GO_Central.
DR CDD; cd05686; S1_pNO40; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR047913; ZCCHC17_S1.
DR InterPro; IPR001878; Znf_CCHC.
DR PANTHER; PTHR15838; NUCLEOLAR PROTEIN OF 40 KDA; 1.
DR PANTHER; PTHR15838:SF1; ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 17; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50126; S1; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT DOMAIN 16..88
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 133..146
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT REGION 160..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..219
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..239
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 239 AA; 27293 MW; D9508FA85F139E05 CRC64;
MNSGRPETME NLPALYTIFQ GEVAMVTDYG AFIKIPGCRK QGLVHRTHMP SCRVDKPSEI
VDVGDKVCVK LIGREMKDDR IKVSLSMKVV DQGTVKDLDP NNVIIEQEER RRWSFQDYTG
QRITLEAVLN ATCKKCGCKG HFAKDCFMQP GGAKYSLIPD EEEEKEEPKS AEFEKPDTTR
NSSRKRKKEK KKKKHRDRKS SDSDSSDSES DTGKRARHTS KDSKAAKKKK KKKKKKHKE
//
