ID F1N989_CHICK Unreviewed; 472 AA.
AC F1N989; F5ANP2;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 96.
DE RecName: Full=5-hydroxytryptamine receptor 2C {ECO:0000256|ARBA:ARBA00017583};
DE AltName: Full=Serotonin receptor 2C {ECO:0000256|ARBA:ARBA00032262};
GN Name=HTR2C {ECO:0000313|EMBL:AEC53544.1,
GN ECO:0000313|Ensembl:ENSGALP00010026916.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:AEC53544.1};
RN [1] {ECO:0000313|EMBL:AEC53544.1}
RP NUCLEOTIDE SEQUENCE.
RA Wong M.T., Kwok A.H.Y., Wang Y., Leung F.C.;
RT "Molecular Characterization of Chicken 5-Hydroxytryptamine (Serotonin)
RT Receptor 2C (HTR2C) Gene.";
RL Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGALP00010026916.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010026916.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; HQ438966; AEC53544.1; -; mRNA.
DR RefSeq; NP_001305350.1; NM_001318421.1.
DR RefSeq; XP_004940707.1; XM_004940650.2.
DR RefSeq; XP_015133917.1; XM_015278431.1.
DR STRING; 9031.ENSGALP00000068654; -.
DR PaxDb; 9031-ENSGALP00000009390; -.
DR Ensembl; ENSGALT00010045052.1; ENSGALP00010026916.1; ENSGALG00010018615.1.
DR GeneID; 428707; -.
DR KEGG; gga:428707; -.
DR CTD; 3358; -.
DR VEuPathDB; HostDB:geneid_428707; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244937; -.
DR HOGENOM; CLU_009579_11_3_1; -.
DR OMA; KEPGIEM; -.
DR OrthoDB; 2880253at2759; -.
DR TreeFam; TF316350; -.
DR Reactome; R-GGA-390666; Serotonin receptors.
DR Reactome; R-GGA-416476; G alpha (q) signalling events.
DR Proteomes; UP000000539; Chromosome 4.
DR Bgee; ENSGALG00000005853; Expressed in brain and 1 other cell type or tissue.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0098666; C:G protein-coupled serotonin receptor complex; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0071886; F:1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding; IEA:Ensembl.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR GO; GO:0001587; F:Gq/11-coupled serotonin receptor activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0051378; F:serotonin binding; IEA:Ensembl.
DR GO; GO:0001662; P:behavioral fear response; IEA:Ensembl.
DR GO; GO:0019934; P:cGMP-mediated signaling; IEA:Ensembl.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007631; P:feeding behavior; IEA:Ensembl.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0007626; P:locomotory behavior; IEA:InterPro.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007208; P:phospholipase C-activating serotonin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0050850; P:positive regulation of calcium-mediated signaling; IEA:Ensembl.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0045600; P:positive regulation of fat cell differentiation; IEA:Ensembl.
DR GO; GO:0010513; P:positive regulation of phosphatidylinositol biosynthetic process; IEA:Ensembl.
DR GO; GO:0032098; P:regulation of appetite; IEA:Ensembl.
DR GO; GO:0043397; P:regulation of corticotropin-releasing hormone secretion; IEA:Ensembl.
DR GO; GO:0031644; P:regulation of nervous system process; IEA:Ensembl.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR CDD; cd15305; 7tmA_5-HT2C; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000377; 5HT2C_rcpt.
DR InterPro; IPR002231; 5HT_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24247; 5-HYDROXYTRYPTAMINE RECEPTOR; 1.
DR PANTHER; PTHR24247:SF32; 5-HYDROXYTRYPTAMINE RECEPTOR 2C; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00517; 5HT2CRECEPTR.
DR PRINTS; PR01101; 5HTRECEPTOR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..472
FT /note="5-hydroxytryptamine receptor 2C"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015090411"
FT TRANSMEM 67..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 82..380
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 472 AA; 52524 MW; 541F6FA84F3E8D21 CRC64;
MSTLSSTGIL LSLTTVSVTL DFSLHGGLMA WSLSTNLTLN QSLPTSDPLN ASEKGEVSRM
SVREKNWPAL LILVVILLTI GGNILVIMAV SLEKKLQNAT NFFLMSLAVA DMLVGILVMP
VSLIAVLYDY AWPLPKQLCP IWISLDVLFS TASIMHLCAI SLDRYVAIRN PIEHSRFNSR
TKAIMKIAAV WTISIGISMP IPVIGLQDDS RVFINGTCVL NDENFVLIGS FMAFFIPLII
MVITYCLTVQ VLQRQATVFM CGEVPKQRRS SVNCLKKENN TEHISMLHNH EGASHLNSPV
SKEAVLFRKG TMQSINNERR ASKVLGIVFF LFLIMWCPFF ITNVMSVLCK EACDKDLLSE
LLDVFVWVGY VCSGVNPLVY TLFNKTYRRA FSSYIRCQYK TSKKSALRQN QCLNVASTAL
YGKDLTLTSY RNGNELNSME LDEAEEGLEM QPGTSELSIN SCNVVSERVS CV
//
