ID   F1NB19_CHICK            Unreviewed;       533 AA.
AC   F1NB19;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 3.
DT   27-MAR-2024, entry version 86.
DE   RecName: Full=Uridine-cytidine kinase {ECO:0000256|RuleBase:RU003825};
DE            EC=2.7.1.48 {ECO:0000256|RuleBase:RU003825};
GN   Name=UCKL1 {ECO:0000313|Ensembl:ENSGALP00010037346.1};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010037346.1, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00010037346.1}
RP   IDENTIFICATION.
RC   STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010037346.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + cytidine = ADP + CMP + H(+); Xref=Rhea:RHEA:24674,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17562, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:60377, ChEBI:CHEBI:456216; EC=2.7.1.48;
CC         Evidence={ECO:0000256|ARBA:ARBA00000503,
CC         ECO:0000256|RuleBase:RU003825};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + uridine = ADP + H(+) + UMP; Xref=Rhea:RHEA:16825,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16704, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57865, ChEBI:CHEBI:456216; EC=2.7.1.48;
CC         Evidence={ECO:0000256|ARBA:ARBA00000734,
CC         ECO:0000256|RuleBase:RU003825};
CC   -!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via salvage pathway;
CC       CTP from cytidine: step 1/3. {ECO:0000256|RuleBase:RU003825}.
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage pathway;
CC       UMP from uridine: step 1/1. {ECO:0000256|ARBA:ARBA00004690,
CC       ECO:0000256|RuleBase:RU003825}.
CC   -!- SIMILARITY: Belongs to the uridine kinase family.
CC       {ECO:0000256|ARBA:ARBA00005408, ECO:0000256|RuleBase:RU003825}.
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DR   RefSeq; NP_001257506.1; NM_001270577.1.
DR   AlphaFoldDB; F1NB19; -.
DR   Ensembl; ENSGALT00010060587.1; ENSGALP00010037346.1; ENSGALG00010024817.1.
DR   GeneID; 419255; -.
DR   KEGG; gga:419255; -.
DR   CTD; 54963; -.
DR   VEuPathDB; HostDB:geneid_419255; -.
DR   GeneTree; ENSGT01020000230412; -.
DR   Proteomes; UP000000539; Chromosome 20.
DR   Bgee; ENSGALG00000006040; Expressed in skeletal muscle tissue and 12 other cell types or tissues.
DR   ExpressionAtlas; F1NB19; baseline and differential.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004849; F:uridine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   CDD; cd02023; UMPK; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR006083; PRK/URK.
DR   InterPro; IPR029057; PRTase-like.
DR   InterPro; IPR000764; Uridine_kinase-like.
DR   NCBIfam; TIGR00235; udk; 1.
DR   PANTHER; PTHR10285; URIDINE KINASE; 1.
DR   PANTHER; PTHR10285:SF68; URIDINE-CYTIDINE KINASE-LIKE 1; 1.
DR   Pfam; PF00485; PRK; 1.
DR   Pfam; PF14681; UPRTase; 1.
DR   PRINTS; PR00988; URIDINKINASE.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF53271; PRTase-like; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU003825};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU003825};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU003825};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003825}.
FT   DOMAIN          86..273
FT                   /note="Phosphoribulokinase/uridine kinase"
FT                   /evidence="ECO:0000259|Pfam:PF00485"
SQ   SEQUENCE   533 AA;  59558 MW;  4D30F7FCCBC387BB CRC64;
     MSSPPTYGSV RFSGCRALAP AGSNSSAESL DRLYPAVGSS KPPRKRTTSQ CKSEPPLLRT
     SKRTIYTAGR PPWYNEHGTQ SKEAFVIGLG GGSASGKTTV ATMIIEALDV PWVVLLSMDS
     FYKVLTKQQQ EQAASNDFNF DHPDAFDFDL IIATLKKLKQ GKSVKIPIYD FTTHSRKKEW
     KTLYGANVII FEGIMAFADK ELLKLLDLKI FVDTDSDIRL VRRLRRDISE RGRDIEGVIK
     QYNKFVKPAF DQYIQPTMRL ADIVVPRGSG NTVAIDLIVQ HVHSQLEERE LSVRAALASA
     HQYHPLPQTL SVLKSTPQVR GMHTIIRNKE TSRDEFIFYS KRLMRLLIEH ALSFLPFQTC
     TVQTPQGQDY EGRTYSGKQI TGVSILRAGE TMEPALRAVC KDVRIGTILI QTNCNTGEPE
     LHYLRLPKDI SEDHVILMDC TVSTGAAAMM AVRVLLDHDV PEDKIFLLSL LMAEMGVHSV
     AYAFPRVKII TTAVDKKVND LFRIIPGIGN FGDRYFGTDA PPDWSDDEDA LST
//