ID F1NB68_CHICK Unreviewed; 557 AA.
AC F1NB68;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 4.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=Paxillin {ECO:0000256|ARBA:ARBA00023808};
GN Name=PXN {ECO:0000313|Ensembl:ENSGALP00010031578.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010031578.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010031578.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010031578.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}. Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the paxillin family.
CC {ECO:0000256|ARBA:ARBA00005813, ECO:0000256|PIRNR:PIRNR037881}.
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DR AlphaFoldDB; F1NB68; -.
DR Ensembl; ENSGALT00010052668.1; ENSGALP00010031578.1; ENSGALG00010021649.1.
DR VEuPathDB; HostDB:geneid_395832; -.
DR GeneTree; ENSGT00940000158897; -.
DR Proteomes; UP000000539; Chromosome 15.
DR Bgee; ENSGALG00000007247; Expressed in colon and 12 other cell types or tissues.
DR ExpressionAtlas; F1NB68; baseline and differential.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0005925; C:focal adhesion; IDA:AgBase.
DR GO; GO:0005886; C:plasma membrane; ISS:AgBase.
DR GO; GO:0001725; C:stress fiber; IDA:AgBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0017166; F:vinculin binding; IPI:AgBase.
DR GO; GO:0035994; P:response to muscle stretch; IDA:AgBase.
DR CDD; cd09336; LIM1_Paxillin_like; 1.
DR CDD; cd09407; LIM2_Paxillin; 1.
DR CDD; cd09338; LIM3_Paxillin_like; 1.
DR CDD; cd09411; LIM4_Paxillin; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 4.
DR Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 1.
DR InterPro; IPR047072; Paxillin_Lim_dom2.
DR InterPro; IPR001904; Paxillin_Lim_dom4.
DR InterPro; IPR047075; Paxillin_TGFB1I1_LIM_dom1.
DR InterPro; IPR017305; Tgfb1i1/Leupaxin/TGFB1I1.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24210; LIM DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24210:SF12; LIM DOMAIN-CONTAINING PROTEIN DDB_G0271356; 1.
DR Pfam; PF00412; LIM; 4.
DR Pfam; PF03535; Paxillin; 1.
DR PIRSF; PIRSF037881; Leupaxin; 2.
DR PRINTS; PR00832; PAXILLIN.
DR SMART; SM00132; LIM; 4.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 5.
DR PROSITE; PS00478; LIM_DOMAIN_1; 3.
DR PROSITE; PS50023; LIM_DOMAIN_2; 4.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PIRNR:PIRNR037881};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
SQ SEQUENCE 557 AA; 61060 MW; D4D662C5C7D8E03C CRC64;
MKDALLADLE STTSHISKRP VFLTEETPYS YPTGNHTYQE IAVPPPVPPP PSSEALNGTV
IDPLDQWQPS VSRYGHQQPQ SQSPIYSSSA KSSSASVPRD GLSSPSPRAS EEEHVYSFPN
KQKSAEPSPT MTSTSLGSNL SELDRLLLEL NAVQHNPPSG FSADEVSRSP SLPNVTGPHY
VIPESSSSAG GKAAPPTKEK PKRNGGRGIE DMRPSVESLL DELESSVPSP VPAITVSQGE
VSSPQRVNAS QQQTRISASS ATRELDELMA SLSDFKFMAQ GKAGGSSSPP STTPKPGSQL
DTMLGSLQSD LNKLGVATVA KGVCGACKKP IAGQVVTAMG KTWHPEHFVC THCQEEIGSR
NFFERDGQPY CEKDYHNLFS PRCYYCNGPI LDKVVTALDR TWHPEHFFCA QCGVFFGPEG
FHEKDGKAYC RKDYFDMFAP KCGGCARAIL ENYISALNTL WHPECFVCRE CFTPFINGSF
FEHDGQPYCE VHYHERRGSL CSGCQKPITG RCITAMGKKF HPEHFVCAFC LKQLNKGTFK
EQNDKPYCQN CFLKLFC
//
