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Database: UniProt
Entry: F1NME3_CHICK
LinkDB: F1NME3_CHICK
Original site: F1NME3_CHICK 
ID   F1NME3_CHICK            Unreviewed;       484 AA.
AC   F1NME3;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 4.
DT   16-OCT-2019, entry version 70.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGALP00000021516};
GN   Name=LPCAT1 {ECO:0000313|Ensembl:ENSGALP00000021516};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000021516, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00000021516, ECO:0000313|Proteomes:UP000000539}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000021516,
RC   ECO:0000313|Proteomes:UP000000539};
RX   PubMed=15592404; DOI=10.1038/nature03154;
RG   International Chicken Genome Sequencing Consortium;
RA   Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C.,
RA   Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E.,
RA   Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W.,
RA   Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C.,
RA   Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E.,
RA   Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J.,
RA   Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M.,
RA   Paton B., Smith J., Morrice D., Daniels L., Tempest H.G.,
RA   Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V.,
RA   Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J.,
RA   van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J.,
RA   Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H.,
RA   Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA   Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA   Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA   Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S.,
RA   Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J.,
RA   Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H.,
RA   Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C.,
RA   Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C.,
RA   Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P.,
RA   King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S.,
RA   Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S.,
RA   Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S.,
RA   Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z.,
RA   Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J.,
RA   Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z.,
RA   Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA   Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA   Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J.,
RA   Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G.,
RA   Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D.,
RA   Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G.,
RA   Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A.,
RA   Mardis E.R., Wilson R.K.;
RT   "Sequence and comparative analysis of the chicken genome provide
RT   unique perspectives on vertebrate evolution.";
RL   Nature 432:695-716(2004).
RN   [2] {ECO:0000313|Ensembl:ENSGALP00000021516}
RP   IDENTIFICATION.
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000021516};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSGALP00000074299}
RP   IDENTIFICATION.
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000074299};
RG   Ensembl;
RL   Submitted (JAN-2019) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AADN05000026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_015137822.1; XM_015282336.1.
DR   SMR; F1NME3; -.
DR   STRING; 9031.ENSGALP00000021516; -.
DR   PaxDb; F1NME3; -.
DR   Ensembl; ENSGALT00000021549; ENSGALP00000021516; ENSGALG00000013189.
DR   Ensembl; ENSGALT00000106688; ENSGALP00000074299; ENSGALG00000013189.
DR   eggNOG; KOG4666; Eukaryota.
DR   eggNOG; ENOG410XSIQ; LUCA.
DR   GeneTree; ENSGT00950000182744; -.
DR   InParanoid; F1NME3; -.
DR   OrthoDB; 1266853at2759; -.
DR   TreeFam; TF323244; -.
DR   Reactome; R-GGA-1482788; Acyl chain remodelling of PC.
DR   Reactome; R-GGA-1482925; Acyl chain remodelling of PG.
DR   Reactome; R-GGA-1483166; Synthesis of PA.
DR   Reactome; R-GGA-1483191; Synthesis of PC.
DR   Reactome; R-GGA-6798695; Neutrophil degranulation.
DR   Proteomes; UP000000539; Chromosome 2.
DR   Bgee; ENSGALG00000013189; Expressed in 11 organ(s), highest expression level in testis.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005811; C:lipid droplet; IEA:Ensembl.
DR   GO; GO:0047184; F:1-acylglycerophosphocholine O-acyltransferase activity; IEA:Ensembl.
DR   GO; GO:0047159; F:1-alkenylglycerophosphocholine O-acyltransferase activity; IEA:Ensembl.
DR   GO; GO:0047191; F:1-alkylglycerophosphocholine O-acyltransferase activity; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:2001246; P:negative regulation of phosphatidylcholine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0036151; P:phosphatidylcholine acyl-chain remodeling; IEA:Ensembl.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045732; P:positive regulation of protein catabolic process; IEA:Ensembl.
DR   GO; GO:0060041; P:retina development in camera-type eye; IEA:Ensembl.
DR   GO; GO:0043129; P:surfactant homeostasis; IEA:Ensembl.
DR   CDD; cd00051; EFh; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR002123; Plipid/glycerol_acylTrfase.
DR   Pfam; PF01553; Acyltransferase; 1.
DR   SMART; SM00054; EFh; 3.
DR   SMART; SM00563; PlsC; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000539};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM      6     28       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      330    365       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN      401    436       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND     343    354       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   REGION      459    484       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    470    484       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   484 AA;  55135 MW;  96C2D53AEDE49AD5 CRC64;
     MTLTLFPIRL FFAAFMMLLA WPFAFIASMG CDEQELEKPL SWWRKIVDIL LKAIMRMMWL
     AGGFHWINVK GRRALPAEAA ILTVAPHSSY FDAIPVTMTF ASIVMKAESK DIPVWGTLIK
     YIRPVFVSRS DQDSRRKTVE EIKRRAQSGK WPQIMIFPEG TCTNRSCLIT FKPGAFIPGV
     PVQPVVLRYP NKLDTITWTW QGPGALEILW LTLCQFHNSV EIEFLPVYIP SEEERKNPVL
     YANNVRRVMA EALGVPVTDY TFEDCQLALA EGQLRLPSDT CLLEFAKLVR SLGLKPETLE
     DDLDKYATRA MKMKKEKAGL KQFSAYLEFP VSHTLESMFA LFDENEDGII DVREFVIALS
     VVCKPSKTLE TIQLAFQLYQ SENGTITEED LAQILKTAMG VSQINVTHLF RAVDEEEKGK
     ITYDDFYRFA ELQPHFAEDY LYPDQMVAES GLETSSLSAP NGICTDFSPE NAEDKNKPLQ
     KKWN
//
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