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Database: UniProt
Entry: F1NPI7_CHICK
LinkDB: F1NPI7_CHICK
Original site: F1NPI7_CHICK 
ID   F1NPI7_CHICK            Unreviewed;       661 AA.
AC   F1NPI7;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   24-JAN-2024, entry version 80.
DE   RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU364117};
DE            EC=3.6.4.12 {ECO:0000256|RuleBase:RU364117};
GN   Name=RECQL {ECO:0000313|Ensembl:ENSGALP00010019658.1};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010019658.1, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00010019658.1}
RP   IDENTIFICATION.
RC   STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010019658.1};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: DNA helicase that may play a role in the repair of DNA that
CC       is damaged by ultraviolet light or other mutagens. Exhibits a
CC       magnesium-dependent ATP-dependent DNA-helicase activity that unwinds
CC       single- and double-stranded DNA in a 3'-5' direction.
CC       {ECO:0000256|ARBA:ARBA00037616}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|RuleBase:RU364117};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364117}.
CC   -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC       {ECO:0000256|ARBA:ARBA00005446, ECO:0000256|RuleBase:RU364117}.
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DR   RefSeq; XP_015145461.1; XM_015289975.1.
DR   RefSeq; XP_015145472.1; XM_015289986.1.
DR   AlphaFoldDB; F1NPI7; -.
DR   SMR; F1NPI7; -.
DR   STRING; 9031.ENSGALP00000021484; -.
DR   PaxDb; 9031-ENSGALP00000021484; -.
DR   Ensembl; ENSGALT00010033301.1; ENSGALP00010019658.1; ENSGALG00010013867.1.
DR   GeneID; 378910; -.
DR   CTD; 5965; -.
DR   VEuPathDB; HostDB:geneid_378910; -.
DR   GeneTree; ENSGT00940000157013; -.
DR   InParanoid; F1NPI7; -.
DR   OMA; FKLSTMV; -.
DR   OrthoDB; 5474026at2759; -.
DR   Proteomes; UP000000539; Chromosome 1.
DR   Bgee; ENSGALG00000013174; Expressed in spleen and 14 other cell types or tissues.
DR   GO; GO:0005694; C:chromosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0043138; F:3'-5' DNA helicase activity; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:1990814; F:DNA/DNA annealing activity; IEA:Ensembl.
DR   GO; GO:0009378; F:four-way junction helicase activity; IBA:GO_Central.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006268; P:DNA unwinding involved in DNA replication; IBA:GO_Central.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR   CDD; cd18015; DEXHc_RecQ1; 1.
DR   CDD; cd18794; SF2_C_RecQ; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR032284; RecQ_Zn-bd.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   NCBIfam; TIGR00614; recQ_fam; 1.
DR   PANTHER; PTHR13710:SF72; ATP-DEPENDENT DNA HELICASE Q1; 1.
DR   PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF16124; RecQ_Zn_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU364117};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU364117};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU364117};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU364117}; Nucleus {ECO:0000256|RuleBase:RU364117};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539}.
SQ   SEQUENCE   661 AA;  74586 MW;  42140CE711C8198B CRC64;
     MTAVEVLEEE LLSIENELQA VEMQIQELLD KQQELIQKKT TLKKLIKQSS GESAAGGSKE
     TETSVEAWNR TDFPWYEKIK TALQNKFKLP KFRSLQLETV NATMAGKDIF LVMPTGGGKS
     LCYQLPAVCS DGFTLVICPL ISLMEDQLMV LDQLGISATL LNASSSKEHV KWVHAQMLDR
     NSQLKLLYVT PEKIAKSKMF MSKLEKAYQA GCLARIAVDE VHCCSQWGHD FRPDYKSLGI
     LKRQFPCAPL IGLTATATNH VLKDAQNILH IQKCITFTAS FNRPNLYYEV RHKPSNNEDF
     IEDIVKLING RYKGLSGIVY CFSQKDSEQV TVSLQKLGIK AGTYHANMDA KYKTKVHKGW
     AANQIQVVVA TVAFGMGIDK PDVRFVIHHS MSKSMENYYQ ESGRAGRDDQ KADCILYYGF
     GDIFRISSMV VMENVGQEKL YDMVSYCQNM NKCRRVLIAR HFDEVWESAN CNRMCDNCCR
     ENSLEKKDIT GYYRDLIKIL EQADNMSEKL TPLKLIDAWS GKGLSKLRVA EVTPPKLPRE
     ELERIIAHLL LQQYLREDFS FTAFATISYL KIGPKAGLLR NEAHIITIQG TTNKKSIHRN
     KPSESSNSEG STENAQTVSK PTPDSAVKKS QDRKRHNCGT NFKAKKPKLQ AGGDDQPVVL
     D
//
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