ID F1NPI7_CHICK Unreviewed; 661 AA.
AC F1NPI7;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 80.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU364117};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU364117};
GN Name=RECQL {ECO:0000313|Ensembl:ENSGALP00010019658.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010019658.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010019658.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010019658.1};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: DNA helicase that may play a role in the repair of DNA that
CC is damaged by ultraviolet light or other mutagens. Exhibits a
CC magnesium-dependent ATP-dependent DNA-helicase activity that unwinds
CC single- and double-stranded DNA in a 3'-5' direction.
CC {ECO:0000256|ARBA:ARBA00037616}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU364117};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364117}.
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446, ECO:0000256|RuleBase:RU364117}.
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DR RefSeq; XP_015145461.1; XM_015289975.1.
DR RefSeq; XP_015145472.1; XM_015289986.1.
DR AlphaFoldDB; F1NPI7; -.
DR SMR; F1NPI7; -.
DR STRING; 9031.ENSGALP00000021484; -.
DR PaxDb; 9031-ENSGALP00000021484; -.
DR Ensembl; ENSGALT00010033301.1; ENSGALP00010019658.1; ENSGALG00010013867.1.
DR GeneID; 378910; -.
DR CTD; 5965; -.
DR VEuPathDB; HostDB:geneid_378910; -.
DR GeneTree; ENSGT00940000157013; -.
DR InParanoid; F1NPI7; -.
DR OMA; FKLSTMV; -.
DR OrthoDB; 5474026at2759; -.
DR Proteomes; UP000000539; Chromosome 1.
DR Bgee; ENSGALG00000013174; Expressed in spleen and 14 other cell types or tissues.
DR GO; GO:0005694; C:chromosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:1990814; F:DNA/DNA annealing activity; IEA:Ensembl.
DR GO; GO:0009378; F:four-way junction helicase activity; IBA:GO_Central.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006268; P:DNA unwinding involved in DNA replication; IBA:GO_Central.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR CDD; cd18015; DEXHc_RecQ1; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF72; ATP-DEPENDENT DNA HELICASE Q1; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU364117};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU364117};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU364117};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU364117}; Nucleus {ECO:0000256|RuleBase:RU364117};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539}.
SQ SEQUENCE 661 AA; 74586 MW; 42140CE711C8198B CRC64;
MTAVEVLEEE LLSIENELQA VEMQIQELLD KQQELIQKKT TLKKLIKQSS GESAAGGSKE
TETSVEAWNR TDFPWYEKIK TALQNKFKLP KFRSLQLETV NATMAGKDIF LVMPTGGGKS
LCYQLPAVCS DGFTLVICPL ISLMEDQLMV LDQLGISATL LNASSSKEHV KWVHAQMLDR
NSQLKLLYVT PEKIAKSKMF MSKLEKAYQA GCLARIAVDE VHCCSQWGHD FRPDYKSLGI
LKRQFPCAPL IGLTATATNH VLKDAQNILH IQKCITFTAS FNRPNLYYEV RHKPSNNEDF
IEDIVKLING RYKGLSGIVY CFSQKDSEQV TVSLQKLGIK AGTYHANMDA KYKTKVHKGW
AANQIQVVVA TVAFGMGIDK PDVRFVIHHS MSKSMENYYQ ESGRAGRDDQ KADCILYYGF
GDIFRISSMV VMENVGQEKL YDMVSYCQNM NKCRRVLIAR HFDEVWESAN CNRMCDNCCR
ENSLEKKDIT GYYRDLIKIL EQADNMSEKL TPLKLIDAWS GKGLSKLRVA EVTPPKLPRE
ELERIIAHLL LQQYLREDFS FTAFATISYL KIGPKAGLLR NEAHIITIQG TTNKKSIHRN
KPSESSNSEG STENAQTVSK PTPDSAVKKS QDRKRHNCGT NFKAKKPKLQ AGGDDQPVVL
D
//