GenomeNet

Database: UniProt
Entry: F1NSR9_CHICK
LinkDB: F1NSR9_CHICK
Original site: F1NSR9_CHICK 
ID   F1NSR9_CHICK            Unreviewed;      4874 AA.
AC   F1NSR9;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 3.
DT   28-MAR-2018, entry version 59.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSGALP00000005342};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSGALP00000005342};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000005342, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00000005342, ECO:0000313|Proteomes:UP000000539}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000005342,
RC   ECO:0000313|Proteomes:UP000000539};
RX   PubMed=15592404; DOI=10.1038/nature03154;
RG   International Chicken Genome Sequencing Consortium;
RA   Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C.,
RA   Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E.,
RA   Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W.,
RA   Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C.,
RA   Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E.,
RA   Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J.,
RA   Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M.,
RA   Paton B., Smith J., Morrice D., Daniels L., Tempest H.G.,
RA   Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V.,
RA   Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J.,
RA   van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J.,
RA   Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H.,
RA   Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA   Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA   Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA   Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S.,
RA   Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J.,
RA   Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H.,
RA   Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C.,
RA   Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C.,
RA   Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P.,
RA   King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S.,
RA   Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S.,
RA   Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S.,
RA   Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z.,
RA   Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J.,
RA   Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z.,
RA   Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA   Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA   Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J.,
RA   Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G.,
RA   Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D.,
RA   Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G.,
RA   Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A.,
RA   Mardis E.R., Wilson R.K.;
RT   "Sequence and comparative analysis of the chicken genome provide
RT   unique perspectives on vertebrate evolution.";
RL   Nature 432:695-716(2004).
RN   [2] {ECO:0000313|Ensembl:ENSGALP00000005342}
RP   IDENTIFICATION.
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000005342};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AADN04000014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC147971; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9031.ENSGALP00000005342; -.
DR   PaxDb; F1NSR9; -.
DR   Ensembl; ENSGALT00000005352; ENSGALP00000005342; ENSGALG00000009705.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; F1NSR9; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Reactome; R-GGA-2672351; Stimuli-sensing channels.
DR   Reactome; R-GGA-5578775; Ion homeostasis.
DR   Proteomes; UP000000539; Chromosome 5.
DR   Bgee; ENSGALG00000009705; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000539};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4189   4213       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4416   4436       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4480   4502       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4675   4696       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4755   4778       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      103    158       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      165    210       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      218    272       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      278    335       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      346    403       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      588    799       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1015   1211       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1257   1471       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3933   3961       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      462    482       {ECO:0000256|SAM:Coils}.
FT   COILED     3226   3246       {ECO:0000256|SAM:Coils}.
FT   COILED     3593   3620       {ECO:0000256|SAM:Coils}.
FT   COILED     4339   4359       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4874 AA;  553185 MW;  30E84D60B371C624 CRC64;
     MAEGGEGGED EIQFLRTDDE VVLQCVSSIH KEQRKFCLAA EGLGNRLCFL EPTSEAKYVP
     PDLCICNFVL EQSLSVRALQ EMLTNTGDNA SEGFVKKAAQ GGHRTLLYGH AILLRHSFSE
     MYLTCLTSSR SQTDKLAFDV GLRENAAGEA CWWTIHPASK QRSEGEKVRI GDDLILVSVS
     SERYLHLSMS NGSIQVDASF MQTLWNVHPT CSGSNITEGY LLGGHVVRFF HGHDECLTIP
     STDQNDSQQK KVLYETGGAG VRARSLWRVE PLRISWSGSN IRWGQPFRLR HITTGMYLAL
     NDDEGLVMLD REKSDTTSSA FCFRASKELK EKQDSTLKRD IDGMGVPEIK YGDSVCFIQH
     VASALWLTYK APDAKSARLG LLKRKVILHQ EGHMDDGLTL QRCQHEESQA ARIIRNTTSL
     FSQFISGNNR TLSPIALPVE EMAQTLQDLI KYFQPPGEDL EHEDKQNKLR SLKNRQNLFK
     DEGMLALVLN CIDRLNDYNS AAHFAEISRV ENGTAWKEIL NLLYELLAAL IRGNRNNCTQ
     FSSNLDWLIS KLDRLESSSG ILEVLHCILI ESPEALNVIA EEHIKSIISL LDKHGRNYKV
     LDVLCSLCVC NGVAVRANQN LICDNLLPRR DLLLQTRLIN DVTSIRPNIF LGVAEGSAQY
     KKWYFELIID QVDPFLTAEP THLRVGWAST SGYAPYPGGG EGWGGNGVGD DLYSFGFDGL
     HLWSGRVPRA VASVNQHLLS SDDVVSCCLD LGVPSISFRI NGQPVQGMFE NFCTEGFFFP
     VVSLSAGVKA RFLLGGRHGE FKFLPPTGYA PCYEALLPKE KMKLEPVKEY KRDSDGVRDL
     LGTTQFLSQA SFIPCPIDTS QIALPFHLEK IRDKLAENIH ELWGMNKIEL GWTYGKIRDD
     NKRHHPCLVE FSKLPETEKN YNLQMSTETL KTLLALGCHI VHANPAAEED LKKVKLPKNY
     IMSNGYKPAP LDLSEVKLLP SQEFLVDKLA ENAHNVWAKD RIKQGWTYGI QQDLKNKRNP
     RLVPYALLDE RTKKSNRDSL REAVRTFAGY GYNVEPPDQE IADQTVEKVS IDKIRFFRVE
     QSYAVKSGKW YFEFEAVTGG DMRVGWARPG CRPDIELGAD DQAFVFEGSK GQRWHQGSGF
     FGRSWQPGDV VGCMINLDDK SIIFTLNGEL LITSKGSELA FADFGIESGF VPICSLGLSQ
     IGRMNLGMDA STFKYYTMCG LQEGFEPFAV NMNRDVAMWF SKRLPTFVNV PKNHPHIEIW
     RIDGTIESPP RLKVTHKTFG TQNSNSDMIY CRLSMPIEFR SSFNFGVGVE NASSDALQKR
     KHSQEFPASS TTCFYSLRIF AGQDPSSVWV GWVTPDYHFY SENFDINKNC TVTVTLGDER
     GRVHESVKRS NCYMVWGGDI AANSQRSGRS NVDLEIGCFV DLATGMLSFT ANGKELGTCY
     QVEPNTKLFP AAFVQPTSTN LIQFELGKLK NTMPLSAAIF KSEERNPVPQ CPPRLDVQTI
     TPVLWSRMPN SFLKVETERV SERHGWVVQC LEPLQMMALH IPEENRCVDI LELCEQEDLM
     KFHYHTLKLY SSVCALGNTR VAYALCSHVD ISQLFYTIDN QYLPGLLRSG FYDLLISIHL
     DHAKQAKLMM NNEFIIPVTE ETRTIKLYPD ETKKHGLPGV GLSTCLKPSF NFSTPCFIVT
     SEEHQTSSPD IPLDTLKSKA ISMLTEAVQC SGSHIRDPVG GHIAFQFVPV LKLIATLLVM
     GVFDDDDVKQ VLILIDPNVF GDHKEEAEEK TEKEEVTQVE EKAVEAGEKA VKETKAPTKG
     LLQTRLPESV KLQMCHLLNY FCDCELQHRV EAIVSFADHY VSKLQYNQKY RYNELMQALN
     MSAALTAKKT KEFRSPPQEQ INMLLNFQLG EDCPCPEEIR DELYDFHDDL LIHCGIPLEE
     EEEEEEDSSL TGKLRSLIYK IKGPPKPEKI EPREEEDKSP TTLKELISQT MVRWSQEDQI
     QDPELVRIMY TLLRRQYDSI GELLQALRKA YTISAASVKD TINLLAALGQ IRSLLSVRMG
     KEEELLMING LGDIMNNKVF YQHPNLMRVL GMHETVMDVM VNVLGGDKSQ IAFPKMVASC
     CRFLCYFCRI SRQNQKAMFE HLSYLLENSS VGLAFPSMRG STPLDVAAAS VMDNNELALA
     LEEPDLDKVV TYLAGCGLQS CPVLLAKGYP DIGWNPIEGE RYLSFLRFAV FVNSESVEEN
     ASVVVKLLIR RPECFGPELR GEGGNGLLAA MQEAIRISEN PTRDLPSQGY KREGDEEEEE
     EEEIVHMGNA IMSFYSALID LLGRCAPEMH LIQSGKGEAI RIRSILRSLV PTEDLVGIIS
     IPLKLSTVNK DGTVNEPDMS ANFCPDHKAP MVLFLDRVYG IKDQSFLLHL LEVGFLPDLR
     ASASLDTVSL STTEAALALN RYICSAVFPL LKRCAPLFSG TEHHASLVDS MLHTIYRLSK
     GRSLTKAQRD TIEECLLAIC HHLRPSMLQQ LLRRLVFDVP LLNEYCKMPL KLLTNHYEQC
     WKYYCLPSGM GSYGIAAEDE LHLTEKLFWG IFDSLSHKKY DPELFRMALP CLSAIAGALP
     PDYLDTRIRS TLEKQTSVDP EGNFDPKPVN TANLVLPEKL EYIVSKYAEH SHDKWAFDKT
     NNGWKYGVSL DENTKTHPLI RPFKTLTEKE KEIYRWPVRE SLKTMLAMGW SLERTKEGGE
     GMLHQRENEK LRSISQSSQG NGYSPAPLDL TNVVLSRELQ GMVEVMAENY HNIWAKKKKM
     ELESKGGGSH PLLVPYDTLT AKEKSRDREK AQELFKFLQV NGIIISRGLN DMDLDASSME
     KRFAFKFLKK ILKYVDSAQE FIAHLEAIVT SGKTEKSPHD QEIKFFAKVL LPLVDQYFTN
     HCLYFLSSPT KTLSSSGYAS NKEKEMVASL FCKLAALVRH RISIFGSDST TMVSCLHILA
     QSLDTRTVMK SGSELVKAGL RAFFENAAED LEKTSENLKL GKFTHSRTQI KGVSQNINYT
     TVALLPVLTS IFEHISQYHF GVDLLLGDVQ VSCYRILCSL YSLGTGKNIY VERQRPALGE
     CLASLAAAIP VAFLEPSLNH YNPLSVFNTK SARERAILGM PDTVEEMCPE IPQLDGLIKE
     INNLAESGAR YTEMPHVIEV ILPMLCNYLS YWWERGSESV PESAGPCCTM ITSEHLSIIL
     GNILKIINNN LGIDEASWMK RIAVYAQPII SKARPDLLKT HFIPTLEKLK KKAIKIVMEE
     EQLRADSKSD TQEAELLILD EFAVLCRDLY AFYPMLIRYV DNNRANWLKK PDADSDELFR
     MVAEVFILWC KSHNFKREEQ NFVIQNEINN LAFLTGDTKS KMSKAMQVKS GGQDQERKKS
     KRRGDLYSIQ TSLIVAALKK MLPIGLNMCT PGDQELISLA KTRYSHRDTD EEVKEHIRNN
     LHLQEKSDDP AVKWQLNLYK DILKSDEPPD PEKNVERVQR ISAALYHLDQ VEQPLRSKKA
     VWHKLLSKQR KRAVVACFRM APLYNLPRHR SINLFLHGYQ NYWIETEEYS FEEKLVQDLA
     TSPKKEEEEE EDTEKEQPDP LHQIILYFSR NALTERSKLE DDPLYIAYAA MMAKSCQEEE
     EEEEEDKEKT FEEKEMEKQR TLYQQARLHD RGAAEMVLQM ISASKGHTGP MVVETLKLGI
     AILNGGNTIV QQKMLDYLKE KKDAGFFQSL SGLMQSCSVL DLNAFERQNK AEGLGMVTEE
     GTLIVRERGE KVLQHDEFTR DLFRFLQLLC EGHNNDFQNY LRTQMGNTTT VNIIISTVDY
     LLRLQESISD FYWYYSGKDV IDESGQRNFS KALAVTKQIF NSLTEYIQGP CIGNQQSLAH
     SRLWDAVVGF LHVFANMQMK LSQDSAQIEL LKELLDLLKD MVVMLLSLLE GNVVNGTIGK
     QMVDTLVESS SNVELILKFF DMFLKLKDLT NSDAFKEHDP DGKGIISKKD FQKSMEAQKQ
     YIQSEIEFLL SCAEADENDM FNYIDFVERF HEPAKDIGFN VAVLLTNLSE HMPNDSRLQS
     LLEPAESVLN YFEPYLGRIE IMGGAKKIER VYFEISESSR MQWEKPQVKE SKRQFIFDVV
     NEGGEQEKME LFVNFCEDTI FEMQLASQIS ESDSAERPEE EEEEEPCYVV DIGDDEEEEK
     SLESPSAFAL ACAAVKKNVA NFFKMVTVKN LRKQYRKVRK MTVKEMVKVF FSFFWILFVG
     VFQLFFTIVW GIFQILWSTV FGGGLVEGAK NIKVTKILGD MPDPTQFGIH DDVTEAEKTE
     GAEHGIRDEL VQFVKGEKGE TDIISDIFGI PTKKEGGSKH GHDAGLGDIA EILGSDIQSS
     LENNARKKKG LQIPETAKEA EAERKVEAEK ADMEDGEKQD KAKEEQSEQP EEGKMKKKKR
     RHGQKIEKPE AVMANFFKAL EIYQTKILHY LARNFYNLRF LALFVAFAIN FILLFYKVTE
     EPLDEVEEDS NLWNSFEEEE EEEGMVFFVL EESTGYMAPA LRALAVIHTI ISFVCVIGYY
     CLKVPLVVFK REKEVARKLE FDGLYITEQP SEDDIKGQWD RLVINTPSFP NNYWDKFVKR
     KVINKYGDLY GAERIAELLG LDKNALDFSP VEESEPEAAS LVSWLSSIDT KYHIWKLGVV
     FTDNSFLYLA WYTTMSILGH YNNFFFAAHL LDIAMGFKTL RTILSSVTHN GKQLVLTVGL
     LAVVVYLYTV VAFNFFRKFY NKSEDEDEPD MKCDDMMTCY LFHMYVGVRA GGGIGDEIED
     PAGDPYEMYR IVFDITFFFF VIVILLAIIQ GLIIDAFGEL RDQQEQVRED METKCFICGI
     GNDYFDTIPH GFETHTLQEH NLANYLFFLM YLINKDETEH TGQESFVWKM YQERCWDFFP
     AGDCFRKQYE DQLG
//
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