ID F1NW60_CHICK Unreviewed; 195 AA.
AC F1NW60;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=DNA replication complex GINS protein PSF1 {ECO:0000256|RuleBase:RU368085};
GN Name=GINS1 {ECO:0000313|Ensembl:ENSGALP00010023899.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010023899.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010023899.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010023899.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Required for correct functioning of the GINS complex, a
CC complex that plays an essential role in the initiation of DNA
CC replication, and progression of DNA replication forks. GINS complex
CC seems to bind preferentially to single-stranded DNA.
CC {ECO:0000256|RuleBase:RU368085}.
CC -!- SUBUNIT: Component of the GINS complex.
CC {ECO:0000256|RuleBase:RU368085}.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU368085}.
CC -!- SIMILARITY: Belongs to the GINS1/PSF1 family.
CC {ECO:0000256|ARBA:ARBA00006677, ECO:0000256|RuleBase:RU368085}.
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DR AlphaFoldDB; F1NW60; -.
DR SMR; F1NW60; -.
DR STRING; 9031.ENSGALP00000010125; -.
DR PaxDb; 9031-ENSGALP00000010125; -.
DR Ensembl; ENSGALT00010040935.1; ENSGALP00010023899.1; ENSGALG00010016952.1.
DR VEuPathDB; HostDB:geneid_425297; -.
DR GeneTree; ENSGT00390000013968; -.
DR InParanoid; F1NW60; -.
DR OMA; NHLCMRR; -.
DR OrthoDB; 166901at2759; -.
DR Proteomes; UP000000539; Chromosome 3.
DR Bgee; ENSGALG00000008538; Expressed in granulocyte and 13 other cell types or tissues.
DR GO; GO:0071162; C:CMG complex; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0000811; C:GINS complex; IBA:GO_Central.
DR GO; GO:1902983; P:DNA strand elongation involved in mitotic DNA replication; IBA:GO_Central.
DR GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:Ensembl.
DR CDD; cd11710; GINS_A_psf1; 1.
DR CDD; cd21696; GINS_B_Psf1; 1.
DR Gene3D; 1.20.58.1030; -; 1.
DR InterPro; IPR021151; GINS_A.
DR InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR InterPro; IPR005339; GINS_Psf1.
DR PANTHER; PTHR12914:SF2; DNA REPLICATION COMPLEX GINS PROTEIN PSF1; 1.
DR PANTHER; PTHR12914; PARTNER OF SLD5; 1.
DR Pfam; PF05916; Sld5; 1.
DR SUPFAM; SSF158573; GINS helical bundle-like; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU368085};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU368085};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539}.
FT DOMAIN 20..109
FT /note="GINS subunit"
FT /evidence="ECO:0000259|Pfam:PF05916"
SQ SEQUENCE 195 AA; 22852 MW; 4D8B658F7A696903 CRC64;
MAGERAVGLV RELQSAAGGR LPPFRAEELR QTLEEMRTLY ERNQADVSEA KSGRTDLIFL
IRFRHCCLLR NQRCIVAYLY DRLLRIRALR WEYGSILPNT IQFHMAAEEV EWFNRYKKSL
ATYMRSVGGE EGLDLTQDIK PPKSLYIEVR CLRDYGEFEI DDGTTVLLKK NSQHFLPRWK
CEQLIRQGVL EHILS
//
