ID F1NW95_CHICK Unreviewed; 146 AA.
AC F1NW95;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 {ECO:0000256|ARBA:ARBA00040285, ECO:0000256|RuleBase:RU363103};
GN Name=NDUFA12 {ECO:0000313|Ensembl:ENSGALP00010013327.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010013327.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010013327.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010013327.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000256|ARBA:ARBA00003195, ECO:0000256|RuleBase:RU363103}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000256|RuleBase:RU363103}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000256|RuleBase:RU363103}; Peripheral membrane protein
CC {ECO:0000256|RuleBase:RU363103}; Matrix side
CC {ECO:0000256|RuleBase:RU363103}.
CC -!- SIMILARITY: Belongs to the complex I NDUFA12 subunit family.
CC {ECO:0000256|ARBA:ARBA00007355, ECO:0000256|RuleBase:RU363103}.
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DR AlphaFoldDB; F1NW95; -.
DR SMR; F1NW95; -.
DR STRING; 9031.ENSGALP00000018456; -.
DR PaxDb; 9031-ENSGALP00000018456; -.
DR Ensembl; ENSGALT00010023036.1; ENSGALP00010013327.1; ENSGALG00010009654.1.
DR VEuPathDB; HostDB:geneid_417907; -.
DR GeneTree; ENSGT00390000005848; -.
DR InParanoid; F1NW95; -.
DR OMA; PRKFIWT; -.
DR Reactome; R-GGA-611105; Respiratory electron transport.
DR Reactome; R-GGA-6799198; Complex I biogenesis.
DR Proteomes; UP000000539; Chromosome 1.
DR Bgee; ENSGALG00000011325; Expressed in heart and 12 other cell types or tissues.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IBA:GO_Central.
DR InterPro; IPR007763; NDUFA12.
DR PANTHER; PTHR12910:SF2; NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12; 1.
DR PANTHER; PTHR12910; NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2; 1.
DR Pfam; PF05071; NDUFA12; 1.
PE 1: Evidence at protein level;
KW Electron transport {ECO:0000256|RuleBase:RU363103};
KW Membrane {ECO:0000256|RuleBase:RU363103};
KW Mitochondrion {ECO:0000256|RuleBase:RU363103};
KW Mitochondrion inner membrane {ECO:0000256|RuleBase:RU363103};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1NW95};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Respiratory chain {ECO:0000256|RuleBase:RU363103};
KW Transport {ECO:0000256|RuleBase:RU363103}.
SQ SEQUENCE 146 AA; 16945 MW; 316A4EA4A9E86A2F CRC64;
MAEYVQVVKR AFKHLGGHGG VRGAILQLLR VNDLKTGTLV GVDKYGNKYY EDKRNFFGRH
RWVVYTSEMN GKNTFWEVDG SMVPPEWHRW LHSMTDDPPT THPPVARKFI WENHKFNLSG
TPGQYVPYST TRKKIQEWIP PTTASK
//
