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Database: UniProt
Entry: F1P7E8_CANLF
LinkDB: F1P7E8_CANLF
Original site: F1P7E8_CANLF 
ID   F1P7E8_CANLF            Unreviewed;      3058 AA.
AC   F1P7E8;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 2.
DT   05-JUN-2019, entry version 56.
DE   SubName: Full=REV3 like, DNA directed polymerase zeta catalytic subunit {ECO:0000313|Ensembl:ENSCAFP00000005876};
GN   Name=REV3L {ECO:0000313|Ensembl:ENSCAFP00000005876,
GN   ECO:0000313|VGNC:VGNC:45488};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000005876, ECO:0000313|Proteomes:UP000002254};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00000005876, ECO:0000313|Proteomes:UP000002254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000005876,
RC   ECO:0000313|Proteomes:UP000002254};
RX   PubMed=16341006; DOI=10.1038/nature04338;
RG   Broad Sequencing Platform;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA   Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA   Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA   Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA   Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA   Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA   Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA   Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA   Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA   Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA   Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA   Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA   Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA   Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA   Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA   Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA   Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA   Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA   Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA   Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA   Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA   Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA   Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA   Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA   Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA   Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA   Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA   Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA   Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA   Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA   Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA   Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA   Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA   Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA   Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2] {ECO:0000313|Ensembl:ENSCAFP00000005876}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000005876};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AAEX03008609; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03008610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; F1P7E8; -.
DR   Ensembl; ENSCAFT00000006343; ENSCAFP00000005876; ENSCAFG00000003942.
DR   VGNC; VGNC:45488; REV3L.
DR   eggNOG; KOG0968; Eukaryota.
DR   eggNOG; COG0417; LUCA.
DR   GeneTree; ENSGT00940000156226; -.
DR   Proteomes; UP000002254; Chromosome 12.
DR   Bgee; ENSCAFG00000003942; Expressed in 3 organ(s), highest expression level in prefrontal cortex.
DR   GO; GO:0016035; C:zeta DNA polymerase complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0019985; P:translesion synthesis; IEA:InterPro.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR032757; DUF4683.
DR   InterPro; IPR030559; PolZ_Rev3.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   PANTHER; PTHR45812; PTHR45812; 2.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 2.
DR   Pfam; PF15735; DUF4683; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002254};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002254}.
FT   DOMAIN       14    112       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      668   1054       DUF4683. {ECO:0000259|Pfam:PF15735}.
FT   DOMAIN     2159   2412       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN     2479   2928       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     2970   3037       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION      192    218       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F1P7E8}.
FT   REGION      408    432       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F1P7E8}.
FT   REGION      446    469       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F1P7E8}.
FT   REGION      550    569       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F1P7E8}.
FT   REGION      613    651       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F1P7E8}.
FT   REGION      956   1016       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F1P7E8}.
FT   REGION     1081   1145       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F1P7E8}.
FT   REGION     1464   1520       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F1P7E8}.
FT   REGION     1769   1797       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F1P7E8}.
FT   REGION     1886   1907       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F1P7E8}.
FT   REGION     2009   2068       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F1P7E8}.
FT   REGION     2145   2164       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F1P7E8}.
FT   COILED     2993   3016       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    615    651       Polar. {ECO:0000256|MobiDB-lite:F1P7E8}.
FT   COMPBIAS    962    981       Basic. {ECO:0000256|MobiDB-lite:F1P7E8}.
FT   COMPBIAS   1117   1145       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                F1P7E8}.
FT   COMPBIAS   1464   1498       Polar. {ECO:0000256|MobiDB-lite:F1P7E8}.
FT   COMPBIAS   1769   1796       Polar. {ECO:0000256|MobiDB-lite:F1P7E8}.
FT   COMPBIAS   2027   2042       Acidic. {ECO:0000256|MobiDB-lite:F1P7E8}.
FT   COMPBIAS   2050   2065       Polar. {ECO:0000256|MobiDB-lite:F1P7E8}.
SQ   SEQUENCE   3058 AA;  344695 MW;  FE70A1A9742C109F CRC64;
     MAFSIDRALN VALGNPSSTA QHVFKVSLVS GMPFYGYHEK EKHFMKIYLY NPAMVKRICE
     LLQSGAIMNK FYQPHEAHIP YLLQLFIDYN LYGMNLINLA AVKFRKARRK SNQLHTTGSC
     KDRLPGNSLT GTLFRWEEDE IPSSLILEGV EPQSTCELEV DAVAADILNR LDIEAQIGGN
     PGLQAIWEDE KQRRRNRNET SQINQPESQD RRFVPATESE KNFQKRLQEI LKQNDFSVTL
     SGSVDYSDGS QEFSAELTLH SEVLSPDTLQ CTPANMVEVH KDTELGKGHA VYKVEEALIN
     EEAILNLMEN SQTFQPLTQR LSESPVFLDS SPDEALVRLL AGLENDGYQG GRNRMPSPCH
     FFGNTKNPQN SDDEENEPQI EKEEMELSLV MSQRWDSNIE EPCAKKRSLC RNTRRSSTEE
     DDSSSEEEME WSNNSLLLAN LSIPQLDGTA DENSDNPLNN ENSRTHSSVI ATSKLSVKPS
     IFHKDAATLE PPSSAKITFQ CKHTSALSSH VLNKEDLIED LPQPNNIEKC IDHSVASFTN
     ESTYSMKYPG SLSSSVHSEN SHKESSKKDI LPVSSCESSI FDYEEDIPSV PRQVPSRKYT
     NIRKIDKDTP FIHMNRHSSE NTLGKNSFNF SDLSHPKNKL PSEGNEKGNS TALNSLFPSS
     LTENCELLSC SGENRTMVHS LDSIADESGL NKLKIRYEEF QEHKTEKPSL SQQAAHYMFF
     PSVVLSNCLS RPQKLSPVTY KLQPSSKQSR LKINKKKLIG HQETSTKTSE TVSTKDNCIQ
     NNPCNSNPEK DNVLASDLIK VTRGAFENKT PIDSFIDCHF GDGTLETEQS FGLYGNKYTL
     RAKRKVNYET EDSESSFVTH NSKISLPHSM EIGESLDGTL KSRKRRKMSK KLPPVIIKYI
     IINRFRGRKN MLVKLGKIDS KEKQVILTEE KMELYKKLAP LKDFWPKVPD SPATKYPIYP
     LTPKKSHRRK SKHKSAKKKT GKQQRTNSEN IKRTLSFRRK RSHAILSPPS PSYNAETEDC
     DLNYSDVMSK LGFLSERSTS PINSSPPRCW SPTDPRAEEM MAAVDKETML FKGPNACINK
     TANSRVEKNS RARAQVKKSK TKLVNPSVVT KKRNKRNQTN KVGDDGKKKP RAKQKQKTNE
     KGMSRKHITI KDEKIKSQPG AEVKFVLKHQ NVSETSNSSG GSQLLFKQKD VSLMGSTIDH
     PLSAPLPTGI HAQQNLSGCF SSFLESKKPV DLQTFPSSRD DLHSSVVCSS LGPGISKINV
     QRSHNQSAMF TLKESTLIQK NIFDLSNHLS QVAQNTQISS GITSPKTEEN ANTQKNYLSS
     IGKLNEYRNS LESKPDQAYA PNFLHCKDSQ QQIVCGSEQS KHNETCSPGN AAAEESQMPN
     NCFVTSLRSP IKQIAWEQKQ RGFILDMSNF KPERVKQRSL SEAISQTKAL SQCKSRNVST
     PSAFGEGQSG LAVLKELLQK RQQKAQNANI MQDPLSNKHQ PNKNISGSLE QNKTVKRTRS
     VTSSRKPRTP RSTKPKEKIP KLIKVDSLNL QNSVQLDNSL SDDSPIFFSD PGFESCYSLE
     DSLSPEHNYN FDINTIGQTG FCSFYSGSQF VPADQNLPQK FLSDAVQDLF PGQAIEKNEF
     LSHDNQKCDE DKHHASDSTS WIRSSTLSPE LFEKSSIDNN ENHRHNQWKS SFHPLTTRSN
     SIMDSFCVQQ AEDCLNEKSR LNRSSVSKEV FLSLSQPGTS DWIQGHTRKE MQQSLDSVNT
     SFTTILSSPD GELVDAASED LELYVSRNND MLTPTPDSSP RSTSSPSQSK NGSFTPRTAH
     ILKPLMSPPS REEIMATLLD HDLSETIYQE PFCSNPSDVP EKPREIGGRL LMVETRLPND
     LAEFEGDFSL EGLRLWKTAF SAMTQNPRPG SPLRNGQAVV NKGSSNSSKM AEDKKIVIMP
     CKCAPSRQLV QAWLQAKEEY ERSKKLSKNE PTGVVKSAEN FSSSVNPDDK PVVPPKMSTT
     PHILPTTAHT KEDVDNSQFA LQAVTTGCSQ TVSESQTLPP VASADDPEKG EDDDDDDNDD
     YYVSYSSPDS PVIPPWQQAT SPDSKILNGD ERPISPVKEL HSLNIENFLK PVKDGIQKSP
     SSEPLEPLVI SPINVRARTG ICESLCLHST PIVQRKFLER LPEASSLSPL STEPKTQKLS
     HKKGSNTDTF RRILLTQAKN QFAAVNTPKK ETSQIDGPSL NNTYGFKVSV QNLQEAKALH
     EIQNLTLISV ELHARTRRDL EPDPEFDPIC ALFYCISSDT PLPDTDKTEL TGVIVIDKDK
     TVSSQDIRYQ TPLLIRSGIT GLEVTYAPDE KALFQEIADI IKRYDPDILL GYEIQMHSWG
     YLLQRAAALS VDLGQMISRV PDDKIENRFA PERDDYGSET MSEINIVGRI TLNLWRIMRN
     EVALTNYTFE NVSFHVLHQR FPLFTFRVLS DWFDNKTDLY RWKMVDHYIS RVRGNLQMLE
     QLDLIGKTSE MARLFGIQFL HVLTRGSQYR VESMMLRIAK PMNYIPVTPS VQQRSQMRAP
     QCVPLIMEPE SRFYSNSVLV LDFQSLYPSI VIAYNYCFST CLGHVENLGK YDEFKFGCTS
     LRVPPDLLYQ IRHDITVSPN GIAFVKPSVR KGVLPRMLEE ILKTRLMVKQ SMKAYKQDRA
     LSRMLDARQL GLKLIANVTF GYTAANFSGR MPCIEVGDSI VHKARETLER AIKLVNDTKK
     WGARVVYGDT DSMFVLLKGA TKEQSFKIGQ EIAEAVTATN PKPVKLKFEK VYLPCVLQTK
     KRYVGYMYET LDQKDPVFDA KGIETVRRDS CPAVSKILER SLKLLFETRD ISLIKQYVQR
     QCMKLLEGKA SIQDFIFAKE YRGSSSYKPG ACVPALELTR KMLTYDRRSE PRVGERVPYV
     IIYGTPGVPL IQLVRRPVEV LQDPTLRLNA TYYITKQILP PLARIFSLIG IDVFNWYHEL
     PRIQKATSSS RSEPEGRKGT ISQYFTTLHC PVCDDLTQHG ICSKCRSQPQ HVAVILNQEI
     RELERKQEQL VKICKNCTGC FDRHIPCVSL NCPVLFKLSR VNRELSKAPY LRQLLDQF
//
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