ID F1PRS3_CANLF Unreviewed; 3020 AA.
AC F1PRS3;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 10-FEB-2021, entry version 59.
DE SubName: Full=Centromere protein F {ECO:0000313|Ensembl:ENSCAFP00000018561};
GN Name=CENPF {ECO:0000313|Ensembl:ENSCAFP00000018561};
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000018561, ECO:0000313|Proteomes:UP000002254};
RN [1] {ECO:0000313|Ensembl:ENSCAFP00000018561, ECO:0000313|Proteomes:UP000002254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000018561,
RC ECO:0000313|Proteomes:UP000002254};
RX PubMed=16341006; DOI=10.1038/nature04338;
RG Broad Sequencing Platform;
RA Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E.,
RA Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F.,
RA Smith D.R., deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W.,
RA Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S.,
RA Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A.,
RA Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P.,
RA Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P.,
RA Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B.,
RA Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A.,
RA Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M.,
RA Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S.,
RA Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L.,
RA Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C.,
RA Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G.,
RA Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A.,
RA Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A.,
RA Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M.,
RA Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L.,
RA LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A.,
RA Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S.,
RA Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T.,
RA Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A.,
RA Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S.,
RA Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M.,
RA Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F.,
RA Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T.,
RA Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C.,
RA Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C.,
RA Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D.,
RA Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H.,
RA Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J.,
RA Zembek L., Zimmer A., Lander E.S.;
RT "Genome sequence, comparative analysis and haplotype structure of the
RT domestic dog.";
RL Nature 438:803-819(2005).
RN [2] {ECO:0000313|Ensembl:ENSCAFP00000018561}
RP IDENTIFICATION.
RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000018561};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
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DR EMBL; AAEX03005109; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAEX03005110; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9612.ENSCAFP00000018561; -.
DR PaxDb; F1PRS3; -.
DR Ensembl; ENSCAFT00000020009; ENSCAFP00000018561; ENSCAFG00000012593.
DR eggNOG; ENOG502QVMD; Eukaryota.
DR GeneTree; ENSGT00730000111187; -.
DR HOGENOM; CLU_236481_0_0_1; -.
DR InParanoid; F1PRS3; -.
DR TreeFam; TF101133; -.
DR Proteomes; UP000002254; Chromosome 7.
DR Bgee; ENSCAFG00000012593; Expressed in thymus and 42 other tissues.
DR GO; GO:0005930; C:axoneme; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR GO; GO:0097539; C:ciliary transition fiber; IEA:Ensembl.
DR GO; GO:0000940; C:condensed chromosome outer kinetochore; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0045120; C:pronucleus; IEA:Ensembl.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0051310; P:metaphase plate congression; IEA:Ensembl.
DR GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0016202; P:regulation of striated muscle tissue development; IEA:Ensembl.
DR GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR InterPro; IPR043513; Cenp-F.
DR InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR InterPro; IPR018463; Centromere_CenpF_N.
DR PANTHER; PTHR18874; PTHR18874; 2.
DR Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR Pfam; PF10473; CENP-F_leu_zip; 3.
DR Pfam; PF10481; CENP-F_N; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002254}.
FT DOMAIN 1..308
FT /note="CENP-F_N"
FT /evidence="ECO:0000259|Pfam:PF10481"
FT DOMAIN 1803..1945
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2041..2180
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2223..2362
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2878..2922
FT /note="CENP-F_C_Rb_bdg"
FT /evidence="ECO:0000259|Pfam:PF10490"
FT REGION 206..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1271..1293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1752..1772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2795..3020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 13..131
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 164..191
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 274..378
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 387..414
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 419..439
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 464..502
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 524..616
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 624..686
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 719..746
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 840..867
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 925..952
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 996..1037
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1049..1069
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1091..1111
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1195..1229
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1458..1521
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1800..1820
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1849..1869
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1877..1907
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1926..1995
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2017..2044
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2052..2188
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2203..2226
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2234..2261
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2269..2440
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2458..2513
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2528..2626
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2628..2735
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2743..2773
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 206..237
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..274
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2795..2815
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2825..2842
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2849..2863
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2864..2893
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2908..2922
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2933..2986
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3020 AA; 346559 MW; D43B9B03A1607676 CRC64;
MSWALEEWKE GLPTRALQKI QELEGQLDKL KKERQQRQFQ LETLEAALQK QKQKVENEKT
EGANLKRENQ SLMEICENLE KTKQKMSHEL QVKESQVNFQ EGQLNSSKKQ IEKLEQELKR
CKSELERSQQ TAQAADVSLR SCTTPQKIFA TPLTPSQYYS GSKYEDLKEK YNKEVEERKR
LEAEVKALQA TTKVSQAIPQ STMNHRDIAR HQASSSVFSW QQEKTPSRLS SSALKTPMRR
DLSAAHLSGE QEVTPSRSTL QTGKRDANGS FCDNSNNSHL LDQLKAQNQE LRNKISDLEL
HLQGQEKEMK GQVNKCHELQ LHLEKAKAEL IEKEKILNKS RDELMRTTAQ YDQASSKCTA
LEQKLRRLSE DLSCQRQNAE SAKCSLEQKI KEKEKEFQEE LSRQQRAFQA LDQESTQMKG
RLTQELQQAK NTHNILQADL DKVTSGKYQL EKTLEEFKQK FCRAEQALQA SQVKESELRK
SNEEAKKEYS LLKSQSEQQA REVCHLEEEL RKAKQSLSQS QNFAEEMRAK NASQETMLRD
LQDKINQQEN SLTLEKLKLA LADLEKQRDC SQDLLKKREH HIEQLNDKLS KLEKESEALL
IALELKKKEY EELKEEKTLF AHWKSENEQL LRQLESEKGS LQSKVNHLET CLKTQQIKSH
EYNEKVRTLE IESENLNVEI RNLHNVIDSK TVEVETQKQA YVDLQQKAEF SDQKHKKEME
NMCLKISELT GQVEDLEHKL QLLSSEVIDK DHRYQDLQAE YESLQDLLKP KDSSLVTNEA
HHRSLLAFEQ SSAMNNSFAN IIGEQGSMPS ERSKCHLEAD QSPRSSAVLQ NRVTSLEFSL
ESQKQMNSDL QKQCQELVQI RGEIEENLIK AEQMHQSFVA ETSQRISKLQ EDSSVHQNAF
SSFLNDKLET EQLREKRNEF TIFLNRKEIE DLAQENETLK EINATLNQEK ITLLQKSESF
SNCIDERDKS ILELSNQYKE ERLLLQQRCE ETGRAFEDLS EKYKATQEKN SELECLLNEC
TSACENRQKE LEHLKETFAR EHQALVTKLA LAEETNQNLV LELGAMQQDL RSEMADIHIN
SKSEVDGLKQ IMTLKEEQGN IQKELNSLIQ EKEHLMLMET KQEHQILEAE PVSDSVKGES
EIKKCHVQLP MDLETGNLPQ DAQSQELSSP KDCDIGTEEK YISVLHELST SQNDNAHLQC
SLQAAMSKLS ELEKMCEMLQ VEKLELMSEL NDSRSECITA TSKMTEVMEK LVNEVKILND
ESGLLQGELE KEMAEGESGE QQNEQKGASL NPLDDRNCYE HLTLSNKEVQ MHFAELQEKF
LSLQSEHKIL HDQHCQVSSK MSELQSYVDA LKAENSMLST SLRNFQGDLV KEEMPEPQAG
HFLSLSFSCV TDSPSLTSLG ESSFCKDLLD QTGEASLLNN LDGTIAANQS NLEEGSCCSP
EEENLTKREI LSAPGRSVED LETQCQMYLQ SLKKLEDKIE SQEILKNKEI KELEQLLSSE
REELDSLRKQ YLSENEQWQQ KLTSVTMEME SKLAAEKKQT EHLSFELEVA RLQLQGLDLS
SRSLLGTDLE DALRGGNTSC DVKESEEYTL ETKERTPKRD IHQICEEGVQ QDLNLEMEKI
TKTSPVRFTG EWSSKQSPET SYETLVQDKT QGCLDISELS LSGPNALVPI DFLETQVTIE
NLQLQVKESS NENLRLLHVI EERDKKIESL LDEIRDLDSK LGLQEAQITT KMEACVELEK
IVEELKKEKS NLSERLESSS RDNQELHQRT ESLEGFNSHL EIGADKLSHA VIEDNVAKVN
DNWRERFLDM ENELKRIKSE KGSIEHHALS VEAELETVQT EKLYLVKDNE NKQKAITCLE
EELSVVTSER NQLHGQLDTL SKEKKELDLM SEKMKQKIQE LESREDECLH PSDMAGAEVK
DKMQLVQRLS SDVTQLLEDN TRLQEQLQSL EKDSQALSLV KSELEIQIEQ LNKEKESLSR
ESESLQARLH ESEHEKLTVA KALEGALMEK GEVAVRLSST QEEVHQLRKG IEKLRIRIEA
DEKKQLHVLE KLRESERKAD ALQDKIENLE RELQMSEENQ ELVILDAENS KAEVETLKTQ
MELTTKSLKD LESDLVTVRF EKENLIKQLQ DKQGQVSELD TLLSSFKGQL EEKEREKIEM
KEESRAALEM LRTQLKELNE EIAALCHDQE IQKVKEQSLD PLVQEIHQLR NNTEKLKARL
EADEKEQLRV LGKLKETEHQ ASLLKDRVES LERELEISGK NQECVVLEAE NSKAEVGTLK
VKIEEMAQNL RDLELDLVHI RSEKENMIKE LQKEQERVSE LELLNSSFEN LLQEKEQEKV
QMSEESKTAV GMLQTQLKEL NEEMAALCHD QDTWKAQEQN LRSQVDALEH EKAQLLQGLE
EAKNNYINVQ SSANSLHQQV EDDKQKLKKK DEEINMLKSQ IHDREQLASK LSQVEGEQQL
WKKQKVELEN LMVELEQKIQ VLQSKNDTLQ DTLEALQKSH KDLEKELELT KMENVSFIEK
VNTMTGKETE LQREMHEMAQ KTSELKEEFI GEKNRLTEEL NTMSEEINSS RGQLKELMLE
NSELKNSLDC IHKDQMEKEE KVREEIANYQ LQLQEAEKKH QALLLDTNKQ YEMEIQTYQE
KLSSKEECLS SQKAEIDLLK SSKEELNNSL KATTQLLEEL KKTKADHVKY TNQLKKENER
AQGKIKLLIK SCKQLEEEKE MLQKELSHLE ATQENQKTGT VVDSNAEELM AEMKELKETL
EEKTKEADEY LDKYCSLLIS HEKLEKAKEM LETQVARLSS RSKPHLQNSP LLNSVVPEAS
LAPSATEKKL SSGQNTASGK RQRSTGIRED GGGTASSTPE TFSKKSRKAV RSGIHPAEEA
KDTEFEPEGL PEVVKKGFAD IPTGKTSPYV LRRTTMPTRT SPRLAAQKLA LSPLSLNKEN
HAETSQPTAG GSRSQKVKVA QQSPADSSTA FREPTTRVSS LPERSSADSP REGLRAKRSR
LAPSPEAVPE SKSSENCRVQ
//
