GenomeNet

Database: UniProt
Entry: F1PRS3_CANLF
LinkDB: F1PRS3_CANLF
Original site: F1PRS3_CANLF 
ID   F1PRS3_CANLF            Unreviewed;      3020 AA.
AC   F1PRS3;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 3.
DT   10-FEB-2021, entry version 59.
DE   SubName: Full=Centromere protein F {ECO:0000313|Ensembl:ENSCAFP00000018561};
GN   Name=CENPF {ECO:0000313|Ensembl:ENSCAFP00000018561};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000018561, ECO:0000313|Proteomes:UP000002254};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00000018561, ECO:0000313|Proteomes:UP000002254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000018561,
RC   ECO:0000313|Proteomes:UP000002254};
RX   PubMed=16341006; DOI=10.1038/nature04338;
RG   Broad Sequencing Platform;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E.,
RA   Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F.,
RA   Smith D.R., deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W.,
RA   Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S.,
RA   Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A.,
RA   Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P.,
RA   Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P.,
RA   Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B.,
RA   Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A.,
RA   Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M.,
RA   Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S.,
RA   Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L.,
RA   Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C.,
RA   Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G.,
RA   Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA   Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A.,
RA   Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A.,
RA   Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M.,
RA   Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L.,
RA   LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A.,
RA   Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S.,
RA   Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T.,
RA   Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A.,
RA   Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S.,
RA   Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M.,
RA   Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F.,
RA   Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T.,
RA   Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C.,
RA   Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C.,
RA   Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D.,
RA   Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H.,
RA   Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J.,
RA   Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2] {ECO:0000313|Ensembl:ENSCAFP00000018561}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000018561};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AAEX03005109; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03005110; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9612.ENSCAFP00000018561; -.
DR   PaxDb; F1PRS3; -.
DR   Ensembl; ENSCAFT00000020009; ENSCAFP00000018561; ENSCAFG00000012593.
DR   eggNOG; ENOG502QVMD; Eukaryota.
DR   GeneTree; ENSGT00730000111187; -.
DR   HOGENOM; CLU_236481_0_0_1; -.
DR   InParanoid; F1PRS3; -.
DR   TreeFam; TF101133; -.
DR   Proteomes; UP000002254; Chromosome 7.
DR   Bgee; ENSCAFG00000012593; Expressed in thymus and 42 other tissues.
DR   GO; GO:0005930; C:axoneme; IEA:Ensembl.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0097539; C:ciliary transition fiber; IEA:Ensembl.
DR   GO; GO:0000940; C:condensed chromosome outer kinetochore; IEA:Ensembl.
DR   GO; GO:0030496; C:midbody; IEA:Ensembl.
DR   GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR   GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0045120; C:pronucleus; IEA:Ensembl.
DR   GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR   GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
DR   GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR   GO; GO:0051310; P:metaphase plate congression; IEA:Ensembl.
DR   GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR   GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0016202; P:regulation of striated muscle tissue development; IEA:Ensembl.
DR   GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR   InterPro; IPR043513; Cenp-F.
DR   InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR   InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR   InterPro; IPR018463; Centromere_CenpF_N.
DR   PANTHER; PTHR18874; PTHR18874; 2.
DR   Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR   Pfam; PF10473; CENP-F_leu_zip; 3.
DR   Pfam; PF10481; CENP-F_N; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002254}.
FT   DOMAIN          1..308
FT                   /note="CENP-F_N"
FT                   /evidence="ECO:0000259|Pfam:PF10481"
FT   DOMAIN          1803..1945
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2041..2180
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2223..2362
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2878..2922
FT                   /note="CENP-F_C_Rb_bdg"
FT                   /evidence="ECO:0000259|Pfam:PF10490"
FT   REGION          206..274
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1271..1293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1752..1772
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2795..3020
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          13..131
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          164..191
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          274..378
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          387..414
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          419..439
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          464..502
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          524..616
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          624..686
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          719..746
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          840..867
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          925..952
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          996..1037
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1049..1069
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1091..1111
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1195..1229
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1458..1521
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1800..1820
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1849..1869
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1877..1907
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1926..1995
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2017..2044
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2052..2188
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2203..2226
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2234..2261
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2269..2440
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2458..2513
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2528..2626
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2628..2735
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2743..2773
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        206..237
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        249..274
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2795..2815
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2825..2842
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2849..2863
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2864..2893
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2908..2922
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2933..2986
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3020 AA;  346559 MW;  D43B9B03A1607676 CRC64;
     MSWALEEWKE GLPTRALQKI QELEGQLDKL KKERQQRQFQ LETLEAALQK QKQKVENEKT
     EGANLKRENQ SLMEICENLE KTKQKMSHEL QVKESQVNFQ EGQLNSSKKQ IEKLEQELKR
     CKSELERSQQ TAQAADVSLR SCTTPQKIFA TPLTPSQYYS GSKYEDLKEK YNKEVEERKR
     LEAEVKALQA TTKVSQAIPQ STMNHRDIAR HQASSSVFSW QQEKTPSRLS SSALKTPMRR
     DLSAAHLSGE QEVTPSRSTL QTGKRDANGS FCDNSNNSHL LDQLKAQNQE LRNKISDLEL
     HLQGQEKEMK GQVNKCHELQ LHLEKAKAEL IEKEKILNKS RDELMRTTAQ YDQASSKCTA
     LEQKLRRLSE DLSCQRQNAE SAKCSLEQKI KEKEKEFQEE LSRQQRAFQA LDQESTQMKG
     RLTQELQQAK NTHNILQADL DKVTSGKYQL EKTLEEFKQK FCRAEQALQA SQVKESELRK
     SNEEAKKEYS LLKSQSEQQA REVCHLEEEL RKAKQSLSQS QNFAEEMRAK NASQETMLRD
     LQDKINQQEN SLTLEKLKLA LADLEKQRDC SQDLLKKREH HIEQLNDKLS KLEKESEALL
     IALELKKKEY EELKEEKTLF AHWKSENEQL LRQLESEKGS LQSKVNHLET CLKTQQIKSH
     EYNEKVRTLE IESENLNVEI RNLHNVIDSK TVEVETQKQA YVDLQQKAEF SDQKHKKEME
     NMCLKISELT GQVEDLEHKL QLLSSEVIDK DHRYQDLQAE YESLQDLLKP KDSSLVTNEA
     HHRSLLAFEQ SSAMNNSFAN IIGEQGSMPS ERSKCHLEAD QSPRSSAVLQ NRVTSLEFSL
     ESQKQMNSDL QKQCQELVQI RGEIEENLIK AEQMHQSFVA ETSQRISKLQ EDSSVHQNAF
     SSFLNDKLET EQLREKRNEF TIFLNRKEIE DLAQENETLK EINATLNQEK ITLLQKSESF
     SNCIDERDKS ILELSNQYKE ERLLLQQRCE ETGRAFEDLS EKYKATQEKN SELECLLNEC
     TSACENRQKE LEHLKETFAR EHQALVTKLA LAEETNQNLV LELGAMQQDL RSEMADIHIN
     SKSEVDGLKQ IMTLKEEQGN IQKELNSLIQ EKEHLMLMET KQEHQILEAE PVSDSVKGES
     EIKKCHVQLP MDLETGNLPQ DAQSQELSSP KDCDIGTEEK YISVLHELST SQNDNAHLQC
     SLQAAMSKLS ELEKMCEMLQ VEKLELMSEL NDSRSECITA TSKMTEVMEK LVNEVKILND
     ESGLLQGELE KEMAEGESGE QQNEQKGASL NPLDDRNCYE HLTLSNKEVQ MHFAELQEKF
     LSLQSEHKIL HDQHCQVSSK MSELQSYVDA LKAENSMLST SLRNFQGDLV KEEMPEPQAG
     HFLSLSFSCV TDSPSLTSLG ESSFCKDLLD QTGEASLLNN LDGTIAANQS NLEEGSCCSP
     EEENLTKREI LSAPGRSVED LETQCQMYLQ SLKKLEDKIE SQEILKNKEI KELEQLLSSE
     REELDSLRKQ YLSENEQWQQ KLTSVTMEME SKLAAEKKQT EHLSFELEVA RLQLQGLDLS
     SRSLLGTDLE DALRGGNTSC DVKESEEYTL ETKERTPKRD IHQICEEGVQ QDLNLEMEKI
     TKTSPVRFTG EWSSKQSPET SYETLVQDKT QGCLDISELS LSGPNALVPI DFLETQVTIE
     NLQLQVKESS NENLRLLHVI EERDKKIESL LDEIRDLDSK LGLQEAQITT KMEACVELEK
     IVEELKKEKS NLSERLESSS RDNQELHQRT ESLEGFNSHL EIGADKLSHA VIEDNVAKVN
     DNWRERFLDM ENELKRIKSE KGSIEHHALS VEAELETVQT EKLYLVKDNE NKQKAITCLE
     EELSVVTSER NQLHGQLDTL SKEKKELDLM SEKMKQKIQE LESREDECLH PSDMAGAEVK
     DKMQLVQRLS SDVTQLLEDN TRLQEQLQSL EKDSQALSLV KSELEIQIEQ LNKEKESLSR
     ESESLQARLH ESEHEKLTVA KALEGALMEK GEVAVRLSST QEEVHQLRKG IEKLRIRIEA
     DEKKQLHVLE KLRESERKAD ALQDKIENLE RELQMSEENQ ELVILDAENS KAEVETLKTQ
     MELTTKSLKD LESDLVTVRF EKENLIKQLQ DKQGQVSELD TLLSSFKGQL EEKEREKIEM
     KEESRAALEM LRTQLKELNE EIAALCHDQE IQKVKEQSLD PLVQEIHQLR NNTEKLKARL
     EADEKEQLRV LGKLKETEHQ ASLLKDRVES LERELEISGK NQECVVLEAE NSKAEVGTLK
     VKIEEMAQNL RDLELDLVHI RSEKENMIKE LQKEQERVSE LELLNSSFEN LLQEKEQEKV
     QMSEESKTAV GMLQTQLKEL NEEMAALCHD QDTWKAQEQN LRSQVDALEH EKAQLLQGLE
     EAKNNYINVQ SSANSLHQQV EDDKQKLKKK DEEINMLKSQ IHDREQLASK LSQVEGEQQL
     WKKQKVELEN LMVELEQKIQ VLQSKNDTLQ DTLEALQKSH KDLEKELELT KMENVSFIEK
     VNTMTGKETE LQREMHEMAQ KTSELKEEFI GEKNRLTEEL NTMSEEINSS RGQLKELMLE
     NSELKNSLDC IHKDQMEKEE KVREEIANYQ LQLQEAEKKH QALLLDTNKQ YEMEIQTYQE
     KLSSKEECLS SQKAEIDLLK SSKEELNNSL KATTQLLEEL KKTKADHVKY TNQLKKENER
     AQGKIKLLIK SCKQLEEEKE MLQKELSHLE ATQENQKTGT VVDSNAEELM AEMKELKETL
     EEKTKEADEY LDKYCSLLIS HEKLEKAKEM LETQVARLSS RSKPHLQNSP LLNSVVPEAS
     LAPSATEKKL SSGQNTASGK RQRSTGIRED GGGTASSTPE TFSKKSRKAV RSGIHPAEEA
     KDTEFEPEGL PEVVKKGFAD IPTGKTSPYV LRRTTMPTRT SPRLAAQKLA LSPLSLNKEN
     HAETSQPTAG GSRSQKVKVA QQSPADSSTA FREPTTRVSS LPERSSADSP REGLRAKRSR
     LAPSPEAVPE SKSSENCRVQ
//
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