ID F1PS12_CANLF Unreviewed; 374 AA.
AC F1PS12;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 2.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Tissue factor {ECO:0000256|ARBA:ARBA00018722};
DE AltName: Full=Coagulation factor III {ECO:0000256|ARBA:ARBA00031171};
GN Name=IL10RB {ECO:0000313|Ensembl:ENSCAFP00845036844.1};
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00845036844.1, ECO:0000313|Proteomes:UP000805418};
RN [1] {ECO:0000313|Ensembl:ENSCAFP00845036844.1}
RP IDENTIFICATION.
RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00845036844.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Initiates blood coagulation by forming a complex with
CC circulating factor VII or VIIa. The [TF:VIIa] complex activates factors
CC IX or X by specific limited proteolysis. TF plays a role in normal
CC hemostasis by initiating the cell-surface assembly and propagation of
CC the coagulation protease cascade. {ECO:0000256|ARBA:ARBA00002201}.
CC -!- SUBUNIT: Interacts with HSPE; the interaction, inhibited by heparin,
CC promotes the generation of activated factor X and activates coagulation
CC in the presence of activated factor VII.
CC {ECO:0000256|ARBA:ARBA00011184}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the tissue factor family.
CC {ECO:0000256|ARBA:ARBA00009197}.
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DR RefSeq; XP_003640120.1; XM_003640072.2.
DR RefSeq; XP_535581.2; XM_535581.4.
DR AlphaFoldDB; F1PS12; -.
DR SMR; F1PS12; -.
DR STRING; 9615.ENSCAFP00000013342; -.
DR PaxDb; 9612-ENSCAFP00000013342; -.
DR Ensembl; ENSCAFT00845046962.1; ENSCAFP00845036844.1; ENSCAFG00845026648.1.
DR GeneID; 478404; -.
DR CTD; 3588; -.
DR VEuPathDB; HostDB:ENSCAFG00845026648; -.
DR GeneTree; ENSGT00940000158231; -.
DR OMA; ASTECDF; -.
DR OrthoDB; 4004685at2759; -.
DR Proteomes; UP000805418; Chromosome 31.
DR Bgee; ENSCAFG00000009065; Expressed in blood and 46 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR GO; GO:1901857; P:positive regulation of cellular respiration; IEA:Ensembl.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IEA:Ensembl.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR015373; Interferon/interleukin_rcp_dom.
DR InterPro; IPR001187; Tissue_factor.
DR PANTHER; PTHR20859; INTERFERON/INTERLEUKIN RECEPTOR; 1.
DR PANTHER; PTHR20859:SF50; INTERLEUKIN-10 RECEPTOR SUBUNIT BETA; 1.
DR Pfam; PF09294; Interfer-bind; 1.
DR Pfam; PF01108; Tissue_fac; 1.
DR PRINTS; PR00346; TISSUEFACTOR.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR PROSITE; PS50853; FN3; 2.
PE 3: Inferred from homology;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Reference proteome {ECO:0000313|Proteomes:UP000805418}.
SQ SEQUENCE 374 AA; 41906 MW; 1270C91D685AD5AA CRC64;
MRRSLRSLLG GCLLMSALGL VPPPKNVRMK SVNFKNILQW ELPAFPKGTL TFTAQYQSYR
KFQDLCTSTA FTECDFSSLS KYGDHTLRVR AEFADEHSDW VNITFCPVDD TMIGPPGMQV
EALANSLHLR FLAPKIENEP ETWTMRNIYN SWAYNVQYWK NGSDEKWPIT CQYDFEVLRD
LEPWTTYCVR VQGFLPERNK TGEWSKPVCE QTANDDTAPS WTVAIVLAAS VCVALLLLGC
SALLWCLYKR TKHVFSPRNC LPQHLKEFLG HPHHNTLLFF SFPPSDENEV FDKLSVITQV
SESSRQSSGN SCTPGTPSGQ GSSELVPKEG ANTQGCSTPL LLSPATEGHQ SGTPPEQTPN
PELSDSRTSK QPQS
//
