ID F1PWZ9_CANLF Unreviewed; 145 AA.
AC F1PWZ9;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 {ECO:0000256|ARBA:ARBA00040285, ECO:0000256|RuleBase:RU363103};
GN Name=NDUFA12 {ECO:0000313|Ensembl:ENSCAFP00845031295.1};
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00845031295.1, ECO:0000313|Proteomes:UP000805418};
RN [1] {ECO:0000313|Ensembl:ENSCAFP00845031295.1}
RP IDENTIFICATION.
RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00845031295.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000256|ARBA:ARBA00003195, ECO:0000256|RuleBase:RU363103}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000256|RuleBase:RU363103}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000256|RuleBase:RU363103}; Peripheral membrane protein
CC {ECO:0000256|RuleBase:RU363103}; Matrix side
CC {ECO:0000256|RuleBase:RU363103}.
CC -!- SIMILARITY: Belongs to the complex I NDUFA12 subunit family.
CC {ECO:0000256|ARBA:ARBA00007355, ECO:0000256|RuleBase:RU363103}.
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DR RefSeq; XP_532652.1; XM_532652.5.
DR AlphaFoldDB; F1PWZ9; -.
DR SMR; F1PWZ9; -.
DR STRING; 9615.ENSCAFP00000009334; -.
DR PaxDb; 9612-ENSCAFP00000009334; -.
DR Ensembl; ENSCAFT00845039965.1; ENSCAFP00845031295.1; ENSCAFG00845022634.1.
DR GeneID; 475428; -.
DR KEGG; cfa:475428; -.
DR CTD; 55967; -.
DR VEuPathDB; HostDB:ENSCAFG00845022634; -.
DR GeneTree; ENSGT00390000005848; -.
DR OMA; PRKFIWT; -.
DR OrthoDB; 821at2759; -.
DR Reactome; R-CFA-611105; Respiratory electron transport.
DR Reactome; R-CFA-6799198; Complex I biogenesis.
DR Proteomes; UP000805418; Chromosome 15.
DR Bgee; ENSCAFG00000006232; Expressed in heart left ventricle and 49 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR GO; GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IEA:Ensembl.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IBA:GO_Central.
DR InterPro; IPR007763; NDUFA12.
DR PANTHER; PTHR12910:SF2; NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12; 1.
DR PANTHER; PTHR12910; NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2; 1.
DR Pfam; PF05071; NDUFA12; 1.
PE 3: Inferred from homology;
KW Electron transport {ECO:0000256|RuleBase:RU363103};
KW Membrane {ECO:0000256|RuleBase:RU363103};
KW Mitochondrion {ECO:0000256|RuleBase:RU363103};
KW Mitochondrion inner membrane {ECO:0000256|RuleBase:RU363103};
KW Reference proteome {ECO:0000313|Proteomes:UP000805418};
KW Respiratory chain {ECO:0000256|RuleBase:RU363103};
KW Transport {ECO:0000256|RuleBase:RU363103}.
SQ SEQUENCE 145 AA; 17123 MW; 7F3296094ADCEE6B CRC64;
MELLQVLKRG LQQVSGHGGL RGYLRVFFRT NDVRVGTLVG EDKYGNKYYE DNKQFFGRHR
WVIYTTEMNG KNTFWDVDGS MVPPEWHRWL HCMTDDPPTV KPPVARKFIW TNHKFNVSGT
PEQYVPYSTT RKKIQEWVPP ATPYK
//
