ID F1Q5N7_DANRE Unreviewed; 1255 AA.
AC F1Q5N7; A0A8N7TCW2;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 3.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Cartilage intermediate layer protein 2 {ECO:0000313|Ensembl:ENSDARP00000061429, ECO:0000313|RefSeq:XP_685991.4};
GN Name=cilp2 {ECO:0000313|Ensembl:ENSDARP00000061429,
GN ECO:0000313|RefSeq:XP_685991.4, ECO:0000313|ZFIN:ZDB-GENE-050208-436};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000061429};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000061429}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000061429};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000061429, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000061429};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_685991.4}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_685991.4};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR EMBL; BX649279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_685991.4; XM_680899.6.
DR STRING; 7955.ENSDARP00000061429; -.
DR PaxDb; 7955-ENSDARP00000061429; -.
DR Ensembl; ENSDART00000061430; ENSDARP00000061429; ENSDARG00000013687.
DR Ensembl; ENSDART00000061430.7; ENSDARP00000061429.6; ENSDARG00000013687.11.
DR GeneID; 557778; -.
DR KEGG; dre:557778; -.
DR AGR; ZFIN:ZDB-GENE-050208-436; -.
DR CTD; 148113; -.
DR ZFIN; ZDB-GENE-050208-436; cilp2.
DR eggNOG; ENOG502QQ8H; Eukaryota.
DR OMA; CGVRRME; -.
DR OrthoDB; 5383253at2759; -.
DR TreeFam; TF330132; -.
DR Proteomes; UP000000437; Chromosome 22.
DR Bgee; ENSDARG00000013687; Expressed in muscle tissue and 8 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR039675; CILP1/CILP2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR025155; WxxW_domain.
DR PANTHER; PTHR15031:SF7; CARTILAGE INTERMEDIATE LAYER PROTEIN 2; 1.
DR PANTHER; PTHR15031; CARTILAGE INTERMEDIATE LAYER PROTEIN CLIP; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF13330; Mucin2_WxxW; 1.
DR Pfam; PF00090; TSP_1; 2.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1255
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041116744"
FT DOMAIN 364..448
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 1226..1255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1255 AA; 141101 MW; 1D112F61A3A1B9A6 CRC64;
MWDFTVVTLV LSTVFVVSLA QGPIWDSSRL RRLNQTDRNR KLAYNTLVEP QTTGVTEWTS
WFNIDHPGGN GDYERLEAIR FYYRERVCSR PVAMEARTTD WVAAADTGEV VHSSLEKGFW
CINKEQPFGR SCSNYHVRFQ CPPVHSYWTD WSEWTPCSAT ACNDVGIQVR QRKCMSTQPL
PLLLSPVCVG PHIERRECST PPCQAMWSQW GSWGACSVTC GKGRRTRRRT CHRSSTKIQC
TGRPIEVQKC GNPCPVKCKR VCPGGRPDKS CSYCICDGQA LHGEVFSITG VPVMNATVAL
ASQAKIIRAH TDAKGQFKMD GLCISPQTQI VIRKDKFAPA TLPVSNNSTD ELWVRAILQS
SEKPYIEKHP EDKVRYEGQR ATLCCRATGS PKPDKYYWYH NGTLLNRTIF KYDEDLILRD
LKPEQSGQYH CKATSLTGSI KSTSAVLTVF TKGTPACKST PETHLIKLPL DCKQPGTDSK
FYNAGRCPHN KCPGALDFDM RCRDGTGFCC GVKEMDAKEI NCGRYTLPIK VVSECGCQTC
VEPKVLVRGR VVATDNDEPL RFGHIYIGKE RIGTTGYQGG FTIQVSPETQ RLVVNFVDPS
QKFIDTIKVF IFDKRGGAVY HDVKVMRKQE PIDINAAESN TIYLGEMKDE DPIGQLVIPP
NSFHKNTGEV YEGTVKASVT FLDPRNITMA AAAPGDLNFV DDEGDMLPLR TYGMFSVDFR
DGENQEVLGA GAVQVLLDTE HVKMQEHIPA MKLWSLNPDT GIWEEESNFQ PTQSTIAGTG
RNKREERTFL IGNMEIRERR LFNLDVPENR RCYVKVRAYM SDKFLPNEQL EGVVINLINL
EPKPGYSSNP RAWGRFDSVI TGPNGACLPA FCDAQRADAY TAYVTAIMGG EELEAAPSMP
KMNPNIIGVS QPYLGKLDYQ RSDHEDSALK KTAFRINLAK PNPNNFDETN GPIYPFQSLI
ACENAPVDAN HFRFFRVEKD KYEYNVVPFQ ESDLTSWTGD YLSWWPNPQE FRACFIKVKI
HGATEIMVRS RNLGGTHPQT RGQLYGIRDI RSTRDLHHPN TSAACLEFKC SGMLFDQGSV
DRSLISVIPQ ANCRRIGINS LLQEYLIKHP PVLQNNESHA FNMLAPVDPL GHNYGIYTVT
DQNPRVAKEI AIGRCFDGTS DGFSREMKSD SGVALTFSCP KRTVNRESLF QRLQTNPGLT
LTQMAREMRE SQGLQVRRGS TQMVAYPFGQ QGRSQNRRAT NTNRRRPASR TQPRQ
//
