ID F1Q6J4_DANRE Unreviewed; 565 AA.
AC F1Q6J4; A0A8M2BHY7;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=DAB adaptor protein 1a {ECO:0000313|Ensembl:ENSDARP00000078343};
DE SubName: Full=Disabled homolog 1 isoform X5 {ECO:0000313|RefSeq:XP_005170204.1};
GN Name=dab1a {ECO:0000313|Ensembl:ENSDARP00000078343,
GN ECO:0000313|RefSeq:XP_005170204.1,
GN ECO:0000313|ZFIN:ZDB-GENE-060528-1};
GN Synonyms=dab1 {ECO:0000313|RefSeq:XP_005170204.1}, si:dkey-242m13.1
GN {ECO:0000313|RefSeq:XP_005170204.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000078343};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000078343}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000078343};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000078343, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000078343};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_005170204.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005170204.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AL953861; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX085194; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX248232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CT583664; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005170204.1; XM_005170147.4.
DR Ensembl; ENSDART00000083908.6; ENSDARP00000078343.6; ENSDARG00000059939.8.
DR Ensembl; ENSDART00000186477.1; ENSDARP00000149515.1; ENSDARG00000059939.8.
DR GeneID; 692351; -.
DR AGR; ZFIN:ZDB-GENE-060528-1; -.
DR CTD; 692351; -.
DR ZFIN; ZDB-GENE-060528-1; dab1a.
DR OrthoDB; 2913989at2759; -.
DR Proteomes; UP000000437; Chromosome 20.
DR Bgee; ENSDARG00000059939; Expressed in retina and 33 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0097477; P:lateral motor column neuron migration; IBA:GO_Central.
DR GO; GO:0021517; P:ventral spinal cord development; IBA:GO_Central.
DR CDD; cd01215; PTB_Dab; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR048559; DAB1/2_SBM.
DR InterPro; IPR048561; Dab_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR PANTHER; PTHR47695:SF4; DISABLED HOMOLOG 1; 1.
DR PANTHER; PTHR47695; PID DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF21792; DAB2_SBM; 1.
DR Pfam; PF00640; PID; 1.
DR SMART; SM00462; PTB; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01179; PID; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 37..169
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 471..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 565 AA; 60850 MW; 7F4F662AF7B51E53 CRC64;
MSTEAELQPA ARPSVRKDSK KRGQDRSEAA LIKRFKGDGV RYKAKLIGID EVTAARGDKL
CQDSMMKLKG IAASARSKGE HKQKVFLTVS FGGIKIFDEK SGVLQHHHAV HEISYIAKDI
TDHRAFGYVC GKEGNHRFVA IKTAQSAEPV ILDLRDLFQL IYEIKQREEI EKKAQKDKQC
EQAVYQTILE EDVEDPVYQY IVFEAGHEPI RDPSEESIYQ VPTSQQKEGV YDVPKRHPNI
NQLELFGDMS TPPDITSPST PASPANTLDP LLAHQTPSEL FTPFNPASVP SGYVTMGAVP
PAWAQQQFAA QAPLAFGVQS PVQVAQVLPG TQPLIWGQAN LFPATQQQWA AMAGAHFSPA
AFMPAQTVGP LPAAMFQTLA PMAVPASCET PTAAMGGAVA GTSASTASSP QHGERTLQRQ
AKMSKEMFKE FQMAKPPAMP ARKGEQPSLS CTTDAFSSYF SRVGMAQDTD DCDDFDISQM
NLTPVTSTTP STNSPPTPAP RQSSPSKSSS HASDPPTDDS FGEAEGSPSR SGEEDAAGDC
PQSPGASEPQ AEPESSETDS PQVGS
//
