ID F1Q6Y6_DANRE Unreviewed; 1910 AA.
AC F1Q6Y6; A0A8M6Z326;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Remodeling and spacing factor 1 isoform X2 {ECO:0000313|RefSeq:XP_017213568.1};
DE SubName: Full=Remodeling and spacing factor 1b, tandem duplicate 1 {ECO:0000313|Ensembl:ENSDARP00000071629};
GN Name=rsf1b.1 {ECO:0000313|Ensembl:ENSDARP00000071629,
GN ECO:0000313|RefSeq:XP_017213568.1,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-5829};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000071629};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000071629}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000071629};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000071629, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000071629};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_017213568.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_017213568.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL929053; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017213568.1; XM_017358079.2.
DR STRING; 7955.ENSDARP00000071629; -.
DR Ensembl; ENSDART00000077161; ENSDARP00000071629; ENSDARG00000068640.
DR Ensembl; ENSDART00000077161.4; ENSDARP00000071629.3; ENSDARG00000068640.5.
DR GeneID; 327618; -.
DR AGR; ZFIN:ZDB-GENE-030131-5829; -.
DR CTD; 327618; -.
DR ZFIN; ZDB-GENE-030131-5829; rsf1b.1.
DR eggNOG; ENOG502QW8S; Eukaryota.
DR HOGENOM; CLU_002056_2_0_1; -.
DR OMA; MTDHCEK; -.
DR OrthoDB; 5490909at2759; -.
DR TreeFam; TF106405; -.
DR Reactome; R-DRE-606279; Deposition of new CENPA-containing nucleosomes at the centromere.
DR Proteomes; UP000000437; Chromosome 10.
DR Bgee; ENSDARG00000068640; Expressed in retina and 19 other cell types or tissues.
DR GO; GO:0031213; C:RSF complex; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IBA:GO_Central.
DR CDD; cd15543; PHD_RSF1; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR028938; Rsf1-like.
DR InterPro; IPR028942; WHIM1_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR14296; REMODELING AND SPACING FACTOR 1; 1.
DR PANTHER; PTHR14296:SF3; REMODELING AND SPACING FACTOR 1; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF15612; WHIM1; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 1: Evidence at protein level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1Q6Y6};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 12..73
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 1369..1419
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 204..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..1369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1518..1892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..323
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..464
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..815
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 828..923
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 924..957
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 958..993
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1014..1127
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1141..1195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1207..1233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1242..1261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1272..1290
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1291..1305
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1314..1334
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1542..1559
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1576..1615
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1630..1650
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1659..1678
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1682..1704
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1739..1778
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1790..1829
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1830..1853
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1910 AA; 215646 MW; D269842AE660F58D CRC64;
MSASEEADGS SPGLCPSFAV ICSFLERYGA LLDLPEVSFP ELERSLQDSS AVPKLLVDLH
VKLLRKIGKS VSAERWEKYL IKICQEFNTT WAWELEKKGY QELTVECKTG ILKYLCECQF
DDNVKFKNAI NEEDPDKMRL QPIGRDKDGL MYWFQLDQDH NVRIYVEEQD DLDGSSWKCI
VRNRDDLAQI LGLLKTQIDP ALLVKKEQEE GSSNNSPNPD DEENKKKEGA EVEKSQDDLS
KSENKENILE KENKKEEGAD ATDALSEKGL KVKEELQKHS ETANGSDVIA GSIKEEPQDD
EKVFSAPSKK AEQTEEVKRK TLEETQRALK NDHQAKIPLK KREMKLSEDF DSNSAGLRNA
PVKESRTCFD DSMSSAEKIN GHVPHLQKEA TDSESLSHFE SNEKTKDAQV DRKMDPNETR
FPSEEKMEVE KPKEKNEAST KQHKTTPGEE KPSELSEKTP DSEVVTENME TIEDIKTTPC
DDTANELPKE KSIKDIPNKE SKEDSLKDAQ SKESKGESLK GSKESKGESL LKDAPSKESK
EESLKDAPSK ESKESSSKGA PSKESKGELF KESKESKKES LKDTPSKESI GESLRDTQSK
ESKESSSKDA PRKESKGESL KDAPSKESKE DSMKDTPSKE SNESLLKESK ESKEESLKDN
PSKESKEEIL KDTPSKESKQ ESLKDTPSKE SKGESLKDAP SKESKESLLK ESKESKEESL
KDPPGKESAK SKDDKTKALS KKESLEDISN EKSAKSLKDD ATKDPSKKES LQDISNESTK
SVSKDDAAQD HFNKESSKDL ASEESGKDQP AKDLSNEESI KNPPNQKPSK DLAKKESQKV
IPESESQKVV SEKDLQKGIP EKGSQKSNPE KESQKSNPEK ESQKSNPEKE SQKSNPEKES
QKSNPEKESQ KSNPEKESQK SNPEKESQNV LPSQKSPNKD QEQAMETESF QSSKSVETRE
IIKPHSDTEK PENAEKTKLH ESNTEKESTQ KPCISEGDKL LTRGESIGSK PCEDTDNPQD
KKQEKSGSSK SRTDTNKSSV SDSKKSETRK KVDAEDKCDA AETAKSDKSE IAEDKDKKSE
STKTSDEVKA PEKPNKSDKE HEKQPNPMET DSEIPKTAEE TTKESVKEAN ATVDNCTSKQ
SERDATSEER EASGVVQEKG KGIKKPGRPS KKSTESQNKD KTVEEEKDDG KRRGRTPLKL
KKPAHRRKAE IQREELKGDS ESETTDGRCL RRSPRICRPT AKAVEIQDKR AERKQATPEK
EKEEEEEEEE EEPVQRKPRK AEPDGQTKPK QVGRRRKRQP WSRMRRKKKS SEDEEDEEES
DSEEEETEED DSDEDYKVEK SKKRRRNRNR ERRSSDSSTS SSEDDTPNDD PCKHCGLPNH
PELILLCDSC DSGYHTACLR PPLMIIPDGE WFCPPCQHKL LCDRLEEQLL NLDAALKKKE
RAERRKERLV YVGISVENII TPSVEVEEEK EEVLVKDKAE TKKSKGWGRR STRAKKYISY
RFDEFDEAIE EAIEEDIKEA EGGGAGRGKD MANITGHRGK DMSTILQEEG KENGRPQRTS
AAQKKKRRRL NDLDSDSTVD EEESEDEFRL SDSSEEEFVA SENAESEDNA PSLEDSDFDS
DAQGSRVNRA NRRKTSRSRI RRKQPPRRRR RPRGYSDEEE LETDEEEEEE DEMVTEGSSE
FSDSDLDVRC RRSYRSRKQE VNYCETSDSD GSQASTNKDK KKKRRRLSSS DSEASFQSAE
SEEEERKPKK IRADSSEEEE SRKRRRRLSL KRRRESEDDD DDDDSDESEE EERPVRKRVN
RIDSDESESE EEEKEVKKSP QEKDTEETSA SKGPSPINDN TAEPPSTNGQ SPIKGLEGVA
PRPGAGATPK NGNTPSIAPN GLEAGAQEED EDDLLGVTDL VDYVCNSEQL
//
