ID F1Q944_DANRE Unreviewed; 762 AA.
AC F1Q944; A0A8M1PIA8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Eosinophil peroxidase isoform 2 precursor {ECO:0000313|RefSeq:NP_997944.2};
DE EC=1.11.1.7 {ECO:0000313|RefSeq:NP_997944.2};
DE SubName: Full=Myeloid-specific peroxidase {ECO:0000313|Ensembl:ENSDARP00000103509};
GN Name=mpx {ECO:0000313|Ensembl:ENSDARP00000103509,
GN ECO:0000313|RefSeq:NP_997944.2,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-9460};
GN Synonyms=drf {ECO:0000313|RefSeq:NP_997944.2}, fj80f04
GN {ECO:0000313|RefSeq:NP_997944.2}, mpo
GN {ECO:0000313|RefSeq:NP_997944.2}, wu:fj80f04
GN {ECO:0000313|RefSeq:NP_997944.2};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000103509};
RN [1] {ECO:0000313|RefSeq:NP_997944.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_997944.2};
RX PubMed=11468162; DOI=10.1182/blood.V98.3.643;
RA Bennett C.M., Kanki J.P., Rhodes J., Liu T.X., Paw B.H., Kieran M.W.,
RA Langenau D.M., Delahaye-Brown A., Zon L.I., Fleming M.D., Look A.T.;
RT "Myelopoiesis in the zebrafish, Danio rerio.";
RL Blood 98:643-651(2001).
RN [2] {ECO:0000313|RefSeq:NP_997944.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_997944.2};
RX PubMed=11698295; DOI=10.1182/blood.V98.10.3087;
RA Lieschke G.J., Oates A.C., Crowhurst M.O., Ward A.C., Layton J.E.;
RT "Morphologic and functional characterization of granulocytes and
RT macrophages in embryonic and adult zebrafish.";
RL Blood 98:3087-3096(2001).
RN [3] {ECO:0000313|RefSeq:NP_997944.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_997944.2};
RX PubMed=14996705;
RA Hsu K., Traver D., Kutok J.L., Hagen A., Liu T.X., Paw B.H., Rhodes J.,
RA Berman J.N., Zon L.I., Kanki J.P., Look A.T.;
RT "The pu.1 promoter drives myeloid gene expression in zebrafish.";
RL Blood 104:1291-1297(2004).
RN [4] {ECO:0000313|RefSeq:NP_997944.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_997944.2};
RX PubMed=15070763;
RA Rawls J.F., Samuel B.S., Gordon J.I.;
RT "Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut
RT microbiota.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:4596-4601(2004).
RN [5] {ECO:0000313|RefSeq:NP_997944.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_997944.2};
RX PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA Song H.D., Sun X.J., Deng M., Zhang G.W., Zhou Y., Wu X.Y., Sheng Y.,
RA Chen Y., Ruan Z., Jiang C.L., Fan H.Y., Zon L.I., Kanki J.P., Liu T.X.,
RA Look A.T., Chen Z.;
RT "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN [6] {ECO:0000313|Ensembl:ENSDARP00000103509}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000103509};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [7] {ECO:0000313|Ensembl:ENSDARP00000103509, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000103509};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [8] {ECO:0000313|RefSeq:NP_997944.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_997944.2};
RX PubMed=30837221; DOI=10.1242/dev.164103;
RA Ghersi J.J., Mahony C.B., Bertrand J.Y.;
RT "bif1, a new BMP signaling inhibitor, regulates embryonic hematopoiesis in
RT the zebrafish. .";
RL Development 146:dev164103-dev164103(2019).
RN [9] {ECO:0000313|RefSeq:NP_997944.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_997944.2};
RX PubMed=30898970; DOI=10.1242/dmm.037903;
RA Zhang A., Wu M., Tan J., Yu N., Xu M., Yu X., Liu W., Zhang Y.;
RT "Establishment of a zebrafish hematological disease model induced by 1,4-
RT benzoquinone. .";
RL Dis. Model. Mech. 12:dmm037903-dmm037903(2019).
RN [10] {ECO:0000313|RefSeq:NP_997944.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_997944.2};
RX PubMed=31057394;
RA Kundap U.P., Paudel Y.N., Kumari Y., Othman I., Shaikh M.F.;
RT "Embelin Prevents Seizure and Associated Cognitive Impairments in a
RT Pentylenetetrazole-Induced Kindling Zebrafish Model.";
RL Front. Pharmacol. 10:315-315(2019).
RN [11] {ECO:0000313|RefSeq:NP_997944.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_997944.2};
RX PubMed=30664660;
RA Ferri-Lagneau K.F., Haider J., Sang S., Leung T.;
RT "Rescue of hematopoietic stem/progenitor cells formation in plcg1 zebrafish
RT mutant.";
RL Sci. Rep. 9:244-244(2019).
RN [12] {ECO:0000313|RefSeq:NP_997944.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_997944.2};
RX PubMed=31073223;
RA Stanic K., Reig G., Wichmann I.A., Opazo J.C., Owen G.I., Corvalan A.H.,
RA Concha M.L., Amigo J.D.;
RT "The Reprimo gene family member, reprimo-like (rprml), is required for
RT blood development in embryonic zebrafish.";
RL Sci. Rep. 9:7131-7131(2019).
RN [13] {ECO:0000313|RefSeq:NP_997944.2}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_997944.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CU681843; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_997944.2; NM_212779.2.
DR Ensembl; ENSDART00000111058; ENSDARP00000103509; ENSDARG00000019521.
DR Ensembl; ENSDART00000111058.4; ENSDARP00000103509.3; ENSDARG00000019521.11.
DR AGR; ZFIN:ZDB-GENE-030131-9460; -.
DR ZFIN; ZDB-GENE-030131-9460; mpx.
DR Proteomes; UP000000437; Chromosome 10.
DR Bgee; ENSDARG00000019521; Expressed in blood and 43 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IDA:ZFIN.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004601; F:peroxidase activity; IDA:ZFIN.
DR GO; GO:0006954; P:inflammatory response; IMP:ZFIN.
DR GO; GO:0010310; P:regulation of hydrogen peroxide metabolic process; IMP:ZFIN.
DR GO; GO:0009617; P:response to bacterium; IDA:ZFIN.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR InterPro; IPR019791; Haem_peroxidase_animal.
DR InterPro; IPR010255; Haem_peroxidase_sf.
DR InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR PANTHER; PTHR11475:SF63; EOSINOPHIL PEROXIDASE; 1.
DR PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR Pfam; PF03098; An_peroxidase; 1.
DR PRINTS; PR00457; ANPEROXIDASE.
DR SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR PROSITE; PS50292; PEROXIDASE_3; 1.
PE 1: Evidence at protein level;
KW Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxidase {ECO:0000313|RefSeq:NP_997944.2};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1Q944};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_997944.2}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..762
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_997944.2"
FT /id="PRO_5035036009"
FT BINDING 487
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ SEQUENCE 762 AA; 85161 MW; 4BA015B1C378E516 CRC64;
MNLPTFLFVV GCCCALSMGA EEESPGRPFI LDSIEEAKKI VDAAYKYSRD ESLARVRKDV
IKPSDKLRLL KQPARKTREA VRAADYMAQT LRLISEKAHH VHKRSINATN LLTQDELQTI
TRMTGCEAQT RPPSCRTTPL INKYRTASGV CNNRKNPLLG ASNTPFARWL PAQYEDAVSQ
PKGWDPNKLY NGAALPMVRL VSNRILATAD ADIESDHDFT FMLTIFGQWV DHDLTFTPFS
PSIRSFSNGI DCENSCERSE PCFPISAPPG DQRLRPNTCL PVFRSAPTCG SGHTAYMFGE
VPNVREQINT LTAYLDAGQV YGSEDGLAKE LRDLTNDGGL LRVNNRFKDN GRELLPFTSV
NTNLCATRQK ILNDSTLTEV PCFIAGDARV NENPALNSLH TLFVREHNRL ARALHVLNPT
WSSETLYQEA RKIVGAFNQI LVIKEYLPLI VGPDAYNRHL GPYPGYNENV DPTIANVFAT
AAFRFAHLTI QPFIFRLDEN YKNHPQFPSV PLYEAFFSPW RVIFEGGIDP VLRGLIGRPA
KLNTQDHMLV NALRERLFAF TSHIALDLAS LNMQRGRDHA IPGYNAWRRF CGLSAPQNEQ
ELAVVMNNTE LARKLIELYG TPENIDVWLG GVAEPFAPGG RVGSLFACLI SRQFQKIRDG
DRLWFESNGV FTTKQKTALA SVSLARIICD NTGILKVPRD PFRFRSPANF VNCGNIPAFD
LEPWKETGDG GINISDIGNE IEIPSQDLPD PGDLQENVVH RV
//
