ID F1QA19_DANRE Unreviewed; 829 AA.
AC F1QA19; A0A8M2B5C6;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=Protein Jade-1 {ECO:0000256|ARBA:ARBA00040212};
DE AltName: Full=Jade family PHD finger protein 1 {ECO:0000256|ARBA:ARBA00041998};
DE AltName: Full=PHD finger protein 17 {ECO:0000256|ARBA:ARBA00042970};
GN Name=jade1 {ECO:0000313|Ensembl:ENSDARP00000042059,
GN ECO:0000313|RefSeq:XP_005158548.1, ECO:0000313|RefSeq:XP_005158549.1,
GN ECO:0000313|RefSeq:XP_017207087.1,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-5648};
GN Synonyms=fi11a04 {ECO:0000313|RefSeq:XP_005158548.1,
GN ECO:0000313|RefSeq:XP_005158549.1, ECO:0000313|RefSeq:XP_017207087.1},
GN phf17 {ECO:0000313|RefSeq:XP_005158548.1,
GN ECO:0000313|RefSeq:XP_005158549.1, ECO:0000313|RefSeq:XP_017207087.1},
GN wu:fi11a04 {ECO:0000313|RefSeq:XP_005158548.1,
GN ECO:0000313|RefSeq:XP_005158549.1, ECO:0000313|RefSeq:XP_017207087.1},
GN zgc:55323 {ECO:0000313|RefSeq:XP_017207087.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000042059};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000042059}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000042059};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000042059, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000042059,
RC ECO:0000313|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_005158548.1, ECO:0000313|RefSeq:XP_017207087.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005158548.1,
RC ECO:0000313|RefSeq:XP_005158549.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000256|ARBA:ARBA00004120}.
CC -!- SIMILARITY: Belongs to the JADE family.
CC {ECO:0000256|ARBA:ARBA00038371}.
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DR EMBL; AL928908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005158548.1; XM_005158491.4.
DR RefSeq; XP_005158549.1; XM_005158492.4.
DR RefSeq; XP_017207087.1; XM_017351598.2.
DR Ensembl; ENSDART00000042060.5; ENSDARP00000042059.3; ENSDARG00000033707.7.
DR Ensembl; ENSDART00000181269.1; ENSDARP00000152238.1; ENSDARG00000033707.7.
DR Ensembl; ENSDART00000185725.1; ENSDARP00000153738.1; ENSDARG00000114251.1.
DR GeneID; 327437; -.
DR AGR; ZFIN:ZDB-GENE-030131-5648; -.
DR CTD; 79960; -.
DR ZFIN; ZDB-GENE-030131-5648; jade1.
DR HOGENOM; CLU_016215_0_0_1; -.
DR OMA; SSTCWSQ; -.
DR OrthoDB; 163389at2759; -.
DR TreeFam; TF316118; -.
DR Proteomes; UP000000437; Chromosome 17.
DR Bgee; ENSDARG00000033707; Expressed in cleaving embryo and 28 other cell types or tissues.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15671; ePHD_JADE; 1.
DR CDD; cd15679; PHD_JADE1; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR019542; Enhancer_polycomb-like_N.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR039546; Jade-1_PHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR PANTHER; PTHR13793:SF79; PROTEIN JADE-1; 1.
DR Pfam; PF10513; EPL1; 1.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 196..246
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 248..362
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 368..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 697..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..390
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..405
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 608..624
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..651
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..754
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 755..780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 781..801
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 829 AA; 94626 MW; D7456A7408D7FF6C CRC64;
MKRSRVPSTS EDSDNGSNST SWSQHSNSKH RKQSGKRPSE VFRTDLITAM KLHDSHQLNP
EDYYELADPW RQEWEKGVQV PVSPESIPQC TVRTVAEKST APLFIKPKKL IRSSESSMLG
YVGIQTLADG MCRYDLNEED VAWLQITNEE FSKMGMQPLD ELTMERVMEE FERRCYDNMS
HAMETEEGLG IEYDEDVVCD VCQSPDGEDG NEMVFCDKCN ICVHQACYGI LKVPEGSWLC
RTCALGIFPK CHLCPKKGGA MKPTRSGTKW VHVSCALWIP EVSIGNPEKM EPITNVSHIP
SNRWALICCL CKEKTGACIQ CSAKSCRVAF HVTCGLHCGL KMNTILTEAD EVKFKSFCPK
HSGLDWNEEE GDDDRPVKVP TREDRSRNRG IDFSASSQTR LSQNPEETRL SERKLRVQQL
EDEFYRFVAA DEVAEHLQLP LEMVDFLFQY WKLKRKVNFN QPLIMPKKEE EDSLARREQE
VLLRRLRLFT HLRQDLERVR NLTYMVSRRE RIKRTLCRVQ EQIFHHHVRL LEQGRVTGIS
STRRLEEAMF YFRTTPPVPA SPQPLKGHCG QNSTLSSSEK GSNSYRSSKH IEADKPAKML
MDGVPSSGDS VRSETVMSAS SRRSEGRTRS GESHRKEEES ERPLEDRRRK SKLWDQVSIK
DKLRHAKSME DTLSSETELD TMDDRLLLSH TNANSVATAP NMYSGSPRKT NASHQGKLVP
NGTSGRHLKN WGSFRIPKRS ERTSAGRQTE RQEADNTADQ NSSLKTFSTS PSSPQIRTRL
RTGSENRRHL EESDLGQSEQ GKRCHTQRLP SPMTRRYGSD VIQRGVLAS
//
