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Database: UniProt
Entry: F1QCK8_DANRE
LinkDB: F1QCK8_DANRE
Original site: F1QCK8_DANRE 
ID   F1QCK8_DANRE            Unreviewed;      1012 AA.
AC   F1QCK8; A0A8M2BLB7; F1R423;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 2.
DT   24-JAN-2024, entry version 92.
DE   SubName: Full=Rho guanine nucleotide exchange factor 18 isoform X2 {ECO:0000313|RefSeq:XP_005174065.1};
DE   SubName: Full=Rho/rac guanine nucleotide exchange factor (GEF) 18b {ECO:0000313|Ensembl:ENSDARP00000120290};
GN   OrderedLocusNames=arhgef18b {ECO:0000313|Ensembl:ENSDARP00000010740,
GN   ECO:0000313|RefSeq:XP_005174065.1,
GN   ECO:0000313|ZFIN:ZDB-GENE-070705-462};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000120290};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000120290}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000120290};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000120290, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000120290};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RG   Genome Reference Consortium Zebrafish;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA   Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA   Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA   Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA   Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA   Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA   Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA   Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA   Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA   Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA   Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA   Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA   Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA   Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA   Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA   Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA   Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA   Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA   Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA   Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA   Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA   Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [3] {ECO:0000313|RefSeq:XP_005174065.1}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005174065.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   EMBL; BX908744; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005174065.1; XM_005174008.3.
DR   PaxDb; 7955-ENSDARP00000010740; -.
DR   Ensembl; ENSDART00000010991.10; ENSDARP00000010740.10; ENSDARG00000042308.10.
DR   Ensembl; ENSDART00000145229.3; ENSDARP00000120290.2; ENSDARG00000042308.10.
DR   GeneID; 562264; -.
DR   KEGG; dre:562264; -.
DR   CTD; 562264; -.
DR   ZFIN; ZDB-GENE-070705-462; arhgef18b.
DR   eggNOG; KOG3520; Eukaryota.
DR   HOGENOM; CLU_002466_0_1_1; -.
DR   OrthoDB; 2917157at2759; -.
DR   TreeFam; TF325887; -.
DR   Proteomes; UP000000437; Chromosome 22.
DR   Bgee; ENSDARG00000042308; Expressed in blastula and 19 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IDA:ZFIN.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0003341; P:cilium movement; IMP:ZFIN.
DR   GO; GO:0035023; P:regulation of Rho protein signal transduction; IBA:GO_Central.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041020; PH_16.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR47440:SF1; RHO/RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR 18; 1.
DR   PANTHER; PTHR47440; RIKEN CDNA A430078G23 GENE; 1.
DR   Pfam; PF17838; PH_16; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:F1QCK8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT   DOMAIN          104..301
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          343..445
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          544..610
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          850..870
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          907..1000
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          695..803
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        7..31
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        544..562
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        591..605
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        909..925
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        957..1000
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1012 AA;  114861 MW;  2F068E825ABABE56 CRC64;
     MTVPHKGPSA QPASSSNPSA SQNSSSSGSI TGEMDEIDAF RVRRPADDTV SLASTVPESL
     IVEDAHYATV RSELEALAQD FEVESWSLAV DQHFSKTHSK EAIKRQDVIY ELIQTEIHHV
     RTLKIMLRVY ARELREALQL DERRLDCLFP RLDSLLELHN HFLSRLRERR VESLQPGSER
     NYAINKLSDI LISQFSGELG DRMKESYGDF CSRHTEAVNH YKEQLQSNKK FQNLMRKLSN
     LSIVRRLGVP ECILLVTQRI TKYPVLLERI LHNTEAGTEE HEGLAQALGL IKDVIVQVDA
     QVSLYEKEAR LREIASKMEP KSLGKIKDGR VFRKEDLSQG RRKLLFEGTV NWKAASGRLK
     DILALLLTDV LVLLQEKDQR YVFSTVDNKP SVISLQKLIV REVAHEERAM FLICASSNEP
     EMYEIHTASK EDRNTWITHI RQAVESCPHT EERLFSEEEE ARVARVREYQ ERLALKDAQI
     TQSLAEKLQL FAELSECVAG LEDSGSRSRL LLRGDTSDLQ QGETLLKAAI TEVENLQNLL
     TSRVRGTSAQ TEGNQSPSLS LLPRRADTFG GYDSNSSALP KNGSIKKKGP GAGGRTRDRS
     QRASSDPQLK EVFTCQDHDE LDEASSPAST NMWSSCKLPE SELYERVLLL SQRLYSLQAI
     ISQQDSHIEL QRASILTAER ERPGSRTRGT DVLLEQEKQR NLEKHREELA NFQRLQSQHR
     QEQARWERER EKQRRLAEAD QQRLKEREEE CRRLETRLAE ERLELERQRQ TYQQDLERLR
     ESTRAVEKEK ERLEQQRKLK KHNTVPNTAA LYTQELTQLS TSSSFNGEFL LGGAGEQTHP
     QKSLLRASLS ASPADYPERP EVHSRRESSC NTLPAKTEVP IHLISTTNQL HKQGSVQQQI
     PTKLAALSKG KEKSGKGKSS HRTDSLASVD MKQMLPIKLS ARDSDGGHKT RRPISPHQPQ
     HSHSDSLSPP DAYSDAQSSL APALPKTHNQ TSQQTLPYTV SDEAAKEDVI FF
//
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