ID F1QCK8_DANRE Unreviewed; 1012 AA.
AC F1QCK8; A0A8M2BLB7; F1R423;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 2.
DT 24-JAN-2024, entry version 92.
DE SubName: Full=Rho guanine nucleotide exchange factor 18 isoform X2 {ECO:0000313|RefSeq:XP_005174065.1};
DE SubName: Full=Rho/rac guanine nucleotide exchange factor (GEF) 18b {ECO:0000313|Ensembl:ENSDARP00000120290};
GN OrderedLocusNames=arhgef18b {ECO:0000313|Ensembl:ENSDARP00000010740,
GN ECO:0000313|RefSeq:XP_005174065.1,
GN ECO:0000313|ZFIN:ZDB-GENE-070705-462};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000120290};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000120290}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000120290};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000120290, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000120290};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_005174065.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005174065.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; BX908744; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005174065.1; XM_005174008.3.
DR PaxDb; 7955-ENSDARP00000010740; -.
DR Ensembl; ENSDART00000010991.10; ENSDARP00000010740.10; ENSDARG00000042308.10.
DR Ensembl; ENSDART00000145229.3; ENSDARP00000120290.2; ENSDARG00000042308.10.
DR GeneID; 562264; -.
DR KEGG; dre:562264; -.
DR CTD; 562264; -.
DR ZFIN; ZDB-GENE-070705-462; arhgef18b.
DR eggNOG; KOG3520; Eukaryota.
DR HOGENOM; CLU_002466_0_1_1; -.
DR OrthoDB; 2917157at2759; -.
DR TreeFam; TF325887; -.
DR Proteomes; UP000000437; Chromosome 22.
DR Bgee; ENSDARG00000042308; Expressed in blastula and 19 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IDA:ZFIN.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0003341; P:cilium movement; IMP:ZFIN.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IBA:GO_Central.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR47440:SF1; RHO/RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR 18; 1.
DR PANTHER; PTHR47440; RIKEN CDNA A430078G23 GENE; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1QCK8};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 104..301
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 343..445
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 850..870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 907..1000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 695..803
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 7..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..605
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 909..925
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 957..1000
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1012 AA; 114861 MW; 2F068E825ABABE56 CRC64;
MTVPHKGPSA QPASSSNPSA SQNSSSSGSI TGEMDEIDAF RVRRPADDTV SLASTVPESL
IVEDAHYATV RSELEALAQD FEVESWSLAV DQHFSKTHSK EAIKRQDVIY ELIQTEIHHV
RTLKIMLRVY ARELREALQL DERRLDCLFP RLDSLLELHN HFLSRLRERR VESLQPGSER
NYAINKLSDI LISQFSGELG DRMKESYGDF CSRHTEAVNH YKEQLQSNKK FQNLMRKLSN
LSIVRRLGVP ECILLVTQRI TKYPVLLERI LHNTEAGTEE HEGLAQALGL IKDVIVQVDA
QVSLYEKEAR LREIASKMEP KSLGKIKDGR VFRKEDLSQG RRKLLFEGTV NWKAASGRLK
DILALLLTDV LVLLQEKDQR YVFSTVDNKP SVISLQKLIV REVAHEERAM FLICASSNEP
EMYEIHTASK EDRNTWITHI RQAVESCPHT EERLFSEEEE ARVARVREYQ ERLALKDAQI
TQSLAEKLQL FAELSECVAG LEDSGSRSRL LLRGDTSDLQ QGETLLKAAI TEVENLQNLL
TSRVRGTSAQ TEGNQSPSLS LLPRRADTFG GYDSNSSALP KNGSIKKKGP GAGGRTRDRS
QRASSDPQLK EVFTCQDHDE LDEASSPAST NMWSSCKLPE SELYERVLLL SQRLYSLQAI
ISQQDSHIEL QRASILTAER ERPGSRTRGT DVLLEQEKQR NLEKHREELA NFQRLQSQHR
QEQARWERER EKQRRLAEAD QQRLKEREEE CRRLETRLAE ERLELERQRQ TYQQDLERLR
ESTRAVEKEK ERLEQQRKLK KHNTVPNTAA LYTQELTQLS TSSSFNGEFL LGGAGEQTHP
QKSLLRASLS ASPADYPERP EVHSRRESSC NTLPAKTEVP IHLISTTNQL HKQGSVQQQI
PTKLAALSKG KEKSGKGKSS HRTDSLASVD MKQMLPIKLS ARDSDGGHKT RRPISPHQPQ
HSHSDSLSPP DAYSDAQSSL APALPKTHNQ TSQQTLPYTV SDEAAKEDVI FF
//