ID F1QD15_DANRE Unreviewed; 743 AA.
AC F1QD15; A0A8M3B2D7;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Prostaglandin F2 receptor inhibitor {ECO:0000313|Ensembl:ENSDARP00000098616};
DE SubName: Full=Prostaglandin F2 receptor negative regulator {ECO:0000313|RefSeq:XP_009302671.1};
GN Name=ptgfrna {ECO:0000313|ZFIN:ZDB-GENE-140207-1};
GN Synonyms=ptgfrn {ECO:0000313|Ensembl:ENSDARP00000098616,
GN ECO:0000313|RefSeq:XP_009302671.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000098616};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000098616}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000098616};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000098616, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000098616};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_009302671.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_009302671.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CU984600; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009302671.1; XM_009304396.3.
DR STRING; 7955.ENSDARP00000098616; -.
DR Ensembl; ENSDART00000112635; ENSDARP00000098616; ENSDARG00000078172.
DR Ensembl; ENSDART00000112635.5; ENSDARP00000098616.3; ENSDARG00000078172.5.
DR GeneID; 101883373; -.
DR KEGG; dre:101883373; -.
DR AGR; ZFIN:ZDB-GENE-140207-1; -.
DR CTD; 101883373; -.
DR ZFIN; ZDB-GENE-140207-1; ptgfrna.
DR eggNOG; ENOG502QVD2; Eukaryota.
DR HOGENOM; CLU_005187_1_0_1; -.
DR OMA; TECSLER; -.
DR OrthoDB; 4103343at2759; -.
DR Proteomes; UP000000437; Chromosome 9.
DR Bgee; ENSDARG00000078172; Expressed in mature ovarian follicle and 26 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR12207:SF3; PROSTAGLANDIN F2 RECEPTOR NEGATIVE REGULATOR; 1.
DR PANTHER; PTHR12207; V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00406; IGv; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 1: Evidence at protein level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1QD15};
KW Receptor {ECO:0000313|RefSeq:XP_009302671.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..743
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041157359"
FT TRANSMEM 697..719
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 34..127
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 147..262
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 293..405
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 418..539
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 554..677
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 743 AA; 81593 MW; E821428B7F1B5454 CRC64;
MDEALLRAVL LFIALALSEG RVVNVPAGPL VHVEGQPVSI RCDVSNYEGP RDQDFEWYLM
MADKMLPLVS TFDGSFTDAS MKDRVNSRDI SFVKLNDAAV ELKFKSVRAT DSGVYRCSTP
STDSVISGNY NADVELKVIG DSLKVSPLIP KAAVSAGESV ELQCNTTRSF TEHTFLSVSW
SVGRANSSGV LEQILTFGPD DKIQTGSNYT QRYADGGLQL DLRGGGFYGL VLKATTPADR
GKYVCTAQEW VRQGRTWRKI LERSEDMGKV EVTATDLQYT VSLAVSVSPQ SAGEPTELRC
QVQQLLYLQN GRLGVSWVYS TRGGAAEVQA EVMVATLDQQ GALTAGAQYQ QRLDRGDIAL
TRTPDNTFIL RILQTADADM GWYSCRVTAW TPDRKGVWTN SKEVQSSPVA VQWTPKTPVL
SVAAHRVREA SSAGSTFEMT CQVSGQNLQD SSYSVLIRFE ESGAGGKSRK VLSLSPDSVL
QLEEWSEPGR IDSVVLEKSG PAEYRFRLYG AQVSDRGFYC CDVTAWTRHQ SQDWTKIISA
ESNKIQVDFV HTGPVFNISI QSDANDVLLG DTVQMKCSVS ILNASPNTGD VAFEVRWFQS
SMRPPDNGVV PLISMDRYGV VKKSGSNHSS LERTDQYSFT LSLHSIQHTD VGEYYCSATP
WLLSPATGAW SKESELSSGR VLLSVRTQMW ESLKMPVGYG LIAALVAGLL SILLGLAVAR
CCFSRNPLHT PRPHNKLRDL EMD
//
