GenomeNet

Database: UniProt
Entry: F1QEX9_DANRE
LinkDB: F1QEX9_DANRE
Original site: F1QEX9_DANRE 
ID   F1QEX9_DANRE            Unreviewed;      5078 AA.
AC   F1QEX9;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 3.
DT   20-JUN-2018, entry version 60.
DE   SubName: Full=Ryanodine receptor 1b (skeletal) {ECO:0000313|Ensembl:ENSDARP00000032856};
GN   Name=ryr1b {ECO:0000313|Ensembl:ENSDARP00000032856,
GN   ECO:0000313|ZFIN:ZDB-GENE-070705-417};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000032856, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000032856}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000032856};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000032856, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000032856,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CR377223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CT025746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU138549; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; FQ311881; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; LO018382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7955.ENSDARP00000032856; -.
DR   PaxDb; F1QEX9; -.
DR   PRIDE; F1QEX9; -.
DR   Ensembl; ENSDART00000036015; ENSDARP00000032856; ENSDARG00000023797.
DR   ZFIN; ZDB-GENE-070705-417; ryr1b.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; F1QEX9; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Reactome; R-DRE-2672351; Stimuli-sensing channels.
DR   Reactome; R-DRE-5578775; Ion homeostasis.
DR   Proteomes; UP000000437; Chromosome 18.
DR   Bgee; ENSDARG00000023797; -.
DR   ExpressionAtlas; F1QEX9; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IMP:ZFIN.
DR   GO; GO:0034599; P:cellular response to oxidative stress; IMP:ZFIN.
DR   GO; GO:0031443; P:fast-twitch skeletal muscle fiber contraction; IMP:ZFIN.
DR   GO; GO:0008345; P:larval locomotory behavior; IMP:ZFIN.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:F1QEX9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   5078 AA;  575144 MW;  3D2213F0B963CA31 CRC64;
     MAEGEGGDEE IQFLRTEDQV VLQCTATVLK EQIKLCLSCE GFGNRLCFLE TTSNAQNVPP
     DLAICSFVLE QSLSVRALQE MLANTVDMTE SSQGGGHRTL LYGHAILLRH YHSSMYLSCL
     TTSRSLTDKL AFDVGLQLDA TGEACWWTIH PASKQRSEGE KVRVGDDLIL VSVSSERYLH
     LSYASGDLMV DASFMQTLWN MNPVCSGCEL AEGYLTGGHV LRLFHGHMDE CLAISTPDQG
     EEERKIAQYE GGAVCSQARS LWRLEPLRIG WSGSHMKWGQ AFRVRHITTG RYLCLDDEKG
     LMVLDPEKAN TKQSAFSFRA SKEKVEGEKK KRDVEGMGIP EIKYGESMCF MQHISTGLWL
     TYAALDAKAA RLGTMKRRVM LHQEGHMDDA LTCSRSQTEE SQAARMIYST TGLFTQFIKG
     LDSLSGKNKS PGPVSLPLDG VILSLQDLIH YFRPPEEELE HEEKQTKLRS LRNRQNLFQE
     EGMITIVLEC IDRLNVYNTA AHFSEFAGEE AAESWKEIVN LLYELLASLI RGNRSNCALF
     CDNLDWLVSK LDRLEASSGI LEVLYCVLIE SPEVLNIIQE NHIKSIISLL DKHGRNHKVL
     DVLRSLCVCN GVAVRSNQNL ITENLLPGRD LLLQTNIVNY ASSVRPNIFL GTCEGSTQYK
     KWYFEVMVDY VESFVTAQAT HLRVGWAMTE GFSPYPGGGE GWGGNGVGDD LYSYGFDGLH
     LWSGHVSRQV ASPNQHALAA DDVVSCCLDL SVPSISFRIN GHPVQGMFEN FNLDGLFFPA
     ISFSAGVKAR FLLGGRHGDF KFLPPPGYAP CYEALLPKDR MRIEPIKEYK HDFEGVRNLL
     GPTQSLTHTS FTPCPVDTAQ IVLPPHLERI REKLAENIHE LWAVTRIEQG WTYGVFRDDN
     KKLHPCLVDF QSLPEPERNY NLQMSGETLK TLLALGCHVG MGDEKAEENL RKIKLPKTYV
     MSSGYKPAPL DLNHVKLTPN QNQLVEKLAE NGHNVWARDR VRQGWTYSIV QDIVNKRNPR
     LVPYNLLDER TKKTNRDSVN NAVRTLIGYG YNIEPPDQES SGHGVEDVHG DKVRIFRAEK
     QYGVTSGKWY FEFEAVTTGE MRVGWARPNV RSDVELGSDE LAYVFNGNRA QRWHIGNDPF
     GRQWQSGDVV GCMIDLIEMN IMFTLNGEML ISDSGSEMAF KDIEIGDGFI PVCTLGLSQV
     GRINLGQNVS SLRYFAICGL QEGFEPFAIN MKRDITMWFS KSLPQFVPVP TDHNHIEVSR
     VDGTVDSAPC IKITHKTFGS QNANTDMLFF RLSMPVEFHL TFKVPAGTTP LTRALTIPEE
     EVLEVDPDSD YEVLKKSASR KEQEEKEKEP SVPKDIPGVK ENDKDTASEK GKKKGFLFKA
     KKAAMITPPP PPPLMPRLIE DVVPDDRDDV DIILNTTTYY YSVRIFAGQE PSEVWVGWVT
     PDFHMYDLNF DLSKVRTVTV TVGDDKGNIH DSIKRSNCYM VWGGEFSSSQ QKFSQEDLVI
     GCLVDLATGL LNFTANGKEI NTFYQVEPNT KLFPAVFVLP SSQNMLQLEL GKLKNIMPLS
     AAMFRSERKN PVPQCPPRLD VQMLTPVIWS RMPNHFLNPV VGRVSERHGW MVECTEPLTM
     MALHIPEENR CIDILELSEQ HDLLQFHYHT LMLYCAVCAL GNNRVAHALC SHVDESQLFY
     AIENTYLPGP LRSGYYDLLI SIHLESAKRN RLGTNREFIV PMTSETLSIT LFPDAEAAHD
     LPGVGLTTCL RPKLHFSPIN FVGTDPDLYT LSPIIPLQNL KTQALSMLTE AVFDGSQAMR
     DPVGGSVEFH FVPILKLIST LLIMGIFNNE DVKHILKMID PSVFGKKEEA EEPAEEAAPK
     EEGEEVKEKE ETAEGEEEAV DEGVGEEEEE ELKELKKEEG EEGEEVEKAV EEEDGEKVDG
     EKAEEEKEAE EVGEEAKEEE EEAPEEGLLQ MKMPESVKLQ MCTLLQYFCD CELRHRVEAI
     MAYSDNFVGQ IQSNQRERYN ELMRAFTMSA AETARRTREF RSPPQEQIFL LTNFKHNPEE
     EDCPVPDEVR ETHNNFHNDL LNHCGVHIEE EVEEEEVDTS LRGRLLTLVD KVKSLKQKKE
     EEEPEPEEEP KPSTLQELIS HTMIHWAQEA FIQNPELVRL MFSLLHRQYD ALGELIRALP
     KAYAISAVSV QDTMEMLECL GQIRSLLIVQ MGPEEERLMI QSIGNIMNNK VFYQHPNLMR
     ALGMHETVME VMVNVLGGGG DSKEIRFPQM VTNCCRFLCY FCRISRQNQR SMFDHLSYLL
     QNSGIGLGMR GSTPLDVAAA SCIDNNELAL ALQEQDLEMV VTYLAGCGLR MCPMLLSKGY
     PDIGWNPGGG ERYLDFLRFA VFVNGESVEE NANVVVRLLI RRPECFGPAL RGEGGAGLLA
     AIEEAIKISE DPARDGPTPK KDRRFMFGGE DQHEENRLHL GNAIMSFYSA LIDLLGRCAP
     EMHLIQAGKG EALRIRAILR SLVPIEDLVG VISLPVQIPT FGKDGQIVEP KMSASFVPDH
     KASMVLFLDR VYGIDNQDFL LHVLEVGFLP DMRASASLDT VAFSTTEMAL ALNRYLCSAV
     LPLLTKCAPL FAGTDHRAIM IDSMLHTIYR LSRGRALTKA QRDVIEDCLM SLVKYLRPSM
     LQHLLRRLVF DVPILNEYAK MPLKLLTNHY ERCWKYYCLP NGWANFGVTS EEELHLSRKL
     FWGIFESLAH KKFDAELFKI AMPCICAIAG AIPPDYVDAS YSSMTEKKAS VDAEGNFDPK
     PVETTNTIIP ERLDAFINKY AEHTHDKWAF EKIQNNWTYG EVLDENAKTH PMLRPYKTFS
     EKDKEIYRWP IKESIKAMLA WEWTLEKARD GETEVKTEVK ATRKISQTAQ ATYDPSQGYS
     PQPVDLIGMA LSRELQSMAE QLAENYHNTW GRKKKMELQA KGGGTHPLLV PYDTLTAKEK
     ARDREKAQDL LKFLQLNGYA VTRGLKDMEQ EISSIEKRFA YGFLQKLLKW MEIAQEFIAH
     LEAVVSSGRV EKSPHEQEIK FFAKILLPLI NQYFKNHCLY FLSTPAKVLG SGGHASNKEK
     EMIASIFCKL AGLVRHRVSL FGTDASAVVN CLHILSRSLD ARTVMKSGPE IVKAGLRSFF
     ESAADDIEKM VENLKLGKVS TKNQVKGVSQ NISYTTTALL PVLTSLFDHI AQHQFGDDVM
     LDDLQISCYR IMCSIYSLGT VKTPHAENQR PALGECLAHL AAAMPVAFLE PNLNEFNSYS
     VYTTKTPRER TILGLPSQVQ ELCLDIPELD VLMKEIGHLA ESGARYTEMP HVIEITLPML
     CNYLPRWWER GPENFPEQEG CLCTDVTSEQ LNQLLGSIMK IVVNNLGIDE ASWMKRLAVF
     AQPIVSRAKP EMLKSHFIPT MEKLKKRSGK VVAEEEQLRM EGKTEVDSEG GTIRDEFAVL
     CRDLYALYPL LIRYVDNNRA RWLTCPDPDA EDLFRMVGEV FIFWSKSHNF KREEQNFVVM
     NEINNMSFLT ADSKSKMSKS NTGRFLGGGS DDDRTKKKRR GDRYSVQTSL IVAALKKLLP
     IGLNMCSPAD QELINLAKIR YSLKDTDEEV REFLQNNLHL QGKVEDPSMR WQMALYKETS
     GKAEDADAPE KVVKRVQEVS AVLYHLELTE HPYKSKKMVW HKLLSKQRRR AVVACFRMTP
     LYNIPRHRAS NMFLDGYKRN WLENEGYSFE DKMIDDLSKA LEQEEEEEEE TESKPDPLHQ
     LILHFSRTAL TEKLKLEVDH LYMSYADIMA KSCHIGEEDE GGEEGGVEPS FEVRQTEMEK
     EMEKQRLLYQ QSRLHDRGAA EMVLQMISAC KGETGVMVSS TLKLGISILN GGNSDVQQRM
     LDYLKDKKDV GFFLSLQALM QTCSVLDLNA FERQNKAEGL GMVSEEGTKE KVMADDEFTC
     DLFRFLQLLC EGHNNDFQNY LRTQTGSTTT INIIICTVDF LLRLQESISD FYWYYSGKDI
     IDEPGKRNFS KAMTVAKQVF NSLTEYIQGP CTGNQQSLAH SRLWDAVVGF LHVFAHMMMK
     LAQDSSQIGL LKELLDLQKD MVVMLLSLLE GNVVNGTIAR QMVDMLVESS SNVEMILKFF
     DMFLKLKDIV ASDAFRDYVT DPRGLISKKD FSKAMDSQKQ YTPSEIQFLL SCSEADENEM
     INFEEFANRF QEPAKDIGFN IAVLLTNLSE HVPHDTRLQN FLEQAESVLN YFRPFLGRIE
     IMGASKRIER IYFEISEANR NQWEMPQVRE SKRQFIFDVV NEGGESEKME LFVNFCEDTI
     FEMNIASQIS EQEEEVIEDE DEEEEEESGG GGGGEGEGEE GNGEEAPPES SSAFADFIKS
     IVNFLSLFTF RNLRRRYRKI RKMTIKDMIV GLVMFLYTVL FGILHFIYSV CKGFFLLIWN
     TLFGGGLVEG AKKMTLTEIL TNMPDPTQDE VHGDLPPEPG ARKVQEAGGA GEGEEGAGGG
     EEEAEEGEED EDGRAGFGPH GGLGDMGETE PEEPPTPEGS PLLKRKLVSE EGVEGEVVVE
     EEKVEEEPAP EPEKADAENG EKEKEAEPET EDKQEEEQAE IAKAKAKAKK GKKEEEVGFE
     LWNELEIQRI KFMNYLSRNF YNLRFLALFI AFALNFILLF YKVSDRLPGE EEEFEGSAMF
     EGSGAFEGSA VFEGSAVFEG SGVFEGSGEA EGSGMEENGE EDEENGFVYY FLEESTGYME
     PAMAFFSILH TIISFLCIIG YNCLKVPLVI FKREKELARK LEFDGLYVTE QPEDDDIKGQ
     WDRLVLNTPS FPNNYWDKFV KRKVLEKYGD IYGRERIAEL LGMDLASLDV SAMTHEKKRQ
     PDPSMFTWLT SIDIKYQIWK FGVVFTDNTF LYLVWYTVMS LLGHFNNFFF ACHLLDIAMG
     VKTLRTILSS VTHNGKQLLM TVGLLAVVVY LYTVVAFNFF RKFYNMSEDE DEPDMKCDDM
     MTCYLFHMYV GVRAGGGIGD EIEDPAGDEY ELYRVVFDIT FFFFVIVILL AIIQGLIIDA
     FGELRDQQEQ VREDMETKCF ICGIGSDYFD STPHGFETHT MEEHNLANYM FFLMYLINKD
     ETEHTGQESY VWKMYQERCW DFFPAGDCFR KQYEDQLG
//
DBGET integrated database retrieval system