ID F1QIT1_DANRE Unreviewed; 694 AA.
AC F1QIT1; A0A8M1N9R2;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 24-JAN-2024, entry version 80.
DE SubName: Full=Protein NLRC3-like {ECO:0000313|RefSeq:NP_001038341.1};
DE SubName: Full=Si:dkey-61p9.9 {ECO:0000313|Ensembl:ENSDARP00000114336};
GN Name=LOC558818 {ECO:0000313|RefSeq:NP_001038341.1};
GN OrderedLocusNames=si:dkey-61p9.9
GN {ECO:0000313|Ensembl:ENSDARP00000114336};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000114336};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000114336}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000114336};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000114336, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000114336};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:NP_001038341.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001038341.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AL935186; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001038341.1; NM_001044876.1.
DR Ensembl; ENSDART00000131964; ENSDARP00000114336; ENSDARG00000092759.
DR Ensembl; ENSDART00000131964.3; ENSDARP00000114336.2; ENSDARG00000092759.4.
DR GeneID; 558818; -.
DR KEGG; dre:558818; -.
DR ZFIN; ZDB-GENE-041210-240; si:dkey-61p9.9.
DR HOGENOM; CLU_002274_3_2_1; -.
DR OMA; ENTCENL; -.
DR OrthoDB; 4155972at2759; -.
DR Proteomes; UP000000437; Alternate scaffold 4.
DR Proteomes; UP000000437; Chromosome 4.
DR Bgee; ENSDARG00000092759; Expressed in zone of skin and 3 other cell types or tissues.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR CDD; cd08321; Pyrin_ASC-like; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106:SF151; B30.2/SPRY DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 1..86
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 186..321
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 694 AA; 80340 MW; 033AF7C18F968664 CRC64;
MASVEELLLK SLEDLENPEL KKFQWHLKKY PKRIYKCEME KADRLDTVDK MVECFGAEDA
VNNTVSILRK INQNNLAEQL ENEHKNQGSA SADSKQVLQE NSKRLKDKLK QDYEQILVGN
TQKGRQKYLD DIYTELYVVE NETGGRENDH EVMQIESRHN QQTAEDKPIK CNDMFKVQPD
TGRRNRRVLT LGIAGVGKTV SVNKFILDWA EGKDNQEIDF IFPLPFRRLN LIKQKESSLI
GLLNKYFFRS PNTLSSLPEE QGKVMFIFDG LDECRFPLTL DEDDGLTDVN EKMNVSKMLP
NLLRRHLMSS SLIWITSRPA AASLIPRDYI DQVTEVRGFN DEQKEQYFIK NSSAEVAGNI
ISHIRKSRSL YIMCHIPVFC WISLTVLQPL LAQESNKKTP TTLTGMYINF LLSQKQQMRE
KYSNDSDPEA NAWSFADIVL KLGKLAFKQL QKGNLIFYKE ELEECGLDVE QAFLFSGLCT
RMFQEEKEVS DAKVYSFVHL SVQEFLAALY VFYTYKIKKA NPFLDSWKKL TWILSKRSLL
KLHKAAVEKT LQSKNGHLDL FLRFLLGLSL ESNQSDLEEL LPRLKLKTEN IKHTTDYIKK
KIEEEKRGQS AERTINLFHC LNELKDDIVE DLQKSLSSGI LISQDLSSAQ WSGLVFVLLM
SEETQEKFEL QKCRRSDEAL MRLMPVVKNT RRAL
//