ID F1QJB5_DANRE Unreviewed; 524 AA.
AC F1QJB5; A0A8M2BDB7;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Bridging integrator 2 isoform X1 {ECO:0000313|RefSeq:XP_005166068.1};
DE SubName: Full=Bridging integrator 2b {ECO:0000313|Ensembl:ENSDARP00000015168};
GN Name=bin2b {ECO:0000313|Ensembl:ENSDARP00000015168,
GN ECO:0000313|RefSeq:XP_005166068.1,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-5598};
GN Synonyms=BIN2 {ECO:0000313|RefSeq:XP_005166068.1}, bin2l
GN {ECO:0000313|RefSeq:XP_005166068.1}, wu:fi05e01
GN {ECO:0000313|RefSeq:XP_005166068.1}, zgc:55758
GN {ECO:0000313|RefSeq:XP_005166068.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000015168};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000015168}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000015168};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000015168, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000015168};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_005166068.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005166068.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CR388007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005166068.1; XM_005166011.4.
DR RefSeq; XP_005166069.1; XM_005166012.3.
DR STRING; 7955.ENSDARP00000015168; -.
DR PaxDb; 7955-ENSDARP00000015168; -.
DR Ensembl; ENSDART00000019939.9; ENSDARP00000015168.7; ENSDARG00000010255.11.
DR Ensembl; ENSDART00000184798.1; ENSDARP00000147269.1; ENSDARG00000010255.11.
DR GeneID; 327387; -.
DR AGR; ZFIN:ZDB-GENE-030131-5598; -.
DR CTD; 327387; -.
DR ZFIN; ZDB-GENE-030131-5598; bin2b.
DR eggNOG; KOG3771; Eukaryota.
DR HOGENOM; CLU_017859_0_0_1; -.
DR OMA; IREQDWI; -.
DR OrthoDB; 4243832at2759; -.
DR TreeFam; TF313542; -.
DR Reactome; R-DRE-6798695; Neutrophil degranulation.
DR Proteomes; UP000000437; Chromosome 6.
DR Bgee; ENSDARG00000010255; Expressed in granulocyte and 24 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0002102; C:podosome; IBA:GO_Central.
DR GO; GO:0005543; F:phospholipid binding; IBA:GO_Central.
DR GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR GO; GO:0097320; P:plasma membrane tubulation; IBA:GO_Central.
DR GO; GO:0071800; P:podosome assembly; IBA:GO_Central.
DR CDD; cd07612; BAR_Bin2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR003005; Amphiphysin.
DR InterPro; IPR046984; BAR_Bin2.
DR InterPro; IPR004148; BAR_dom.
DR PANTHER; PTHR46514; AMPHIPHYSIN; 1.
DR PANTHER; PTHR46514:SF1; BRIDGING INTEGRATOR 2; 1.
DR Pfam; PF03114; BAR; 1.
DR PRINTS; PR01251; AMPHIPHYSIN.
DR SMART; SM00721; BAR; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR PROSITE; PS51021; BAR; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1QJB5};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 36..252
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT REGION 267..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 126..198
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 327..365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..382
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..404
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..445
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 524 AA; 59294 MW; 937F7E96FA190AF8 CRC64;
MADGKLGTNI GGNIGAGAGI LAKRFQKSMN RAQEKVLQKL GKTMETKDEQ FEECSANLNK
QQTDGIRLYK DVKAYYNAVK VMHESSKRLS QTLKDIYEPD WHGVEDLTVI MESEDLLWND
YEEKLNDQVV RTMENYTAQF QDVKERVAKR GRKLVDYDST RHHLEALQSA KKRDDAKVNK
AEEEFNKAQE VFEDINKELR EELPVLYQSR ISCYVTMFQN ISNLRDVFYK EMSMLNHNIY
NMMKKLEDQH STKPFIVKGL NSSKSKKRKS VTISAPIPCN TAFPTDHPAM SKLSMPDTLA
HTDTRIHTPS KSTEISESES DSFDSEPNTP KRQSLCSVRS DGASENTSGS TTDETVQANG
QEHQDSVSVE RQEEEESKLS QAASSEDAHN ASTDGDDQTK LLSADEDKPA PIPTPRRSST
SKKDEGETNE NTKGSSEDVK EQKTEYENPP GFLYKAVALK SQDSDEGVLL LFEKGDLILT
FVDDEEEKPD GFVWGVREQD WIQYKDLTLL SGIVEESEIE RITS
//
