ID F1QJQ0_DANRE Unreviewed; 751 AA.
AC F1QJQ0; A0A8M1P3X5; F1QN06;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=LON peptidase N-terminal domain and RING finger protein 1 {ECO:0000313|RefSeq:NP_001264163.1};
DE SubName: Full=LON peptidase N-terminal domain and ring finger 1,-like {ECO:0000313|Ensembl:ENSDARP00000123656};
GN Name=lonrf1 {ECO:0000313|ZFIN:ZDB-GENE-081104-397};
GN Synonyms=si:dkey-258f14.5 {ECO:0000313|RefSeq:NP_001264163.1};
GN OrderedLocusNames=lonrf1l {ECO:0000313|Ensembl:ENSDARP00000123656,
GN ECO:0000313|RefSeq:NP_001264163.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000123656};
RN [1] {ECO:0000313|RefSeq:NP_001264163.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001264163.1};
RX PubMed=21390203;
RA Weger B.D., Sahinbas M., Otto G.W., Mracek P., Armant O., Dolle D.,
RA Lahiri K., Vallone D., Ettwiller L., Geisler R., Foulkes N.S., Dickmeis T.;
RT "The light responsive transcriptome of the zebrafish: function and
RT regulation.";
RL PLoS ONE 6:e17080-e17080(2011).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000123656}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000123656};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:NP_001264163.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001264163.1};
RX PubMed=23236462;
RA Mracek P., Santoriello C., Idda M.L., Pagano C., Ben-Moshe Z., Gothilf Y.,
RA Vallone D., Foulkes N.S.;
RT "Regulation of per and cry genes reveals a central role for the D-box
RT enhancer in light-dependent gene expression.";
RL PLoS ONE 7:e51278-e51278(2012).
RN [4] {ECO:0000313|Ensembl:ENSDARP00000123656, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000123656};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|RefSeq:NP_001264163.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001264163.1};
RX PubMed=24423866;
RA Ben-Moshe Z., Alon S., Mracek P., Faigenbloom L., Tovin A., Vatine G.D.,
RA Eisenberg E., Foulkes N.S., Gothilf Y.;
RT "The light-induced transcriptome of the zebrafish pineal gland reveals
RT complex regulation of the circadian clockwork by light.";
RL Nucleic Acids Res. 42:3750-3767(2014).
RN [6] {ECO:0000313|RefSeq:NP_001264163.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001264163.1};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [7] {ECO:0000313|RefSeq:NP_001264163.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001264163.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CR786572; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU468725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU856174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001264163.1; NM_001277234.1.
DR STRING; 7955.ENSDARP00000130965; -.
DR PaxDb; 7955-ENSDARP00000123656; -.
DR Ensembl; ENSDART00000144516.3; ENSDARP00000123656.1; ENSDARG00000078567.5.
DR Ensembl; ENSDART00000172119.2; ENSDARP00000130965.1; ENSDARG00000078567.5.
DR GeneID; 100317496; -.
DR KEGG; dre:100317496; -.
DR AGR; ZFIN:ZDB-GENE-081104-397; -.
DR CTD; 91694; -.
DR ZFIN; ZDB-GENE-081104-397; lonrf1.
DR eggNOG; KOG4159; Eukaryota.
DR HOGENOM; CLU_013989_1_1_1; -.
DR OMA; KYKKQGV; -.
DR OrthoDB; 3088759at2759; -.
DR TreeFam; TF327043; -.
DR Reactome; R-DRE-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR Proteomes; UP000000437; Chromosome 8.
DR Bgee; ENSDARG00000078567; Expressed in caudal fin and 27 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR CDD; cd16513; RING-HC_LONFs_rpt1; 1.
DR CDD; cd16514; RING-HC_LONFs_rpt2; 1.
DR Gene3D; 2.30.130.40; LON domain-like; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR003111; Lon_prtase_N.
DR InterPro; IPR046336; Lon_prtase_N_sf.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR23327:SF4; LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN 1; 1.
DR PANTHER; PTHR23327; RING FINGER PROTEIN 127; 1.
DR Pfam; PF02190; LON_substr_bdg; 1.
DR Pfam; PF13181; TPR_8; 1.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00464; LON; 1.
DR SMART; SM00184; RING; 2.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF88697; PUA domain-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51787; LON_N; 1.
DR PROSITE; PS00518; ZF_RING_1; 2.
DR PROSITE; PS50089; ZF_RING_2; 2.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 108..144
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 457..495
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 543..744
FT /note="Lon N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51787"
SQ SEQUENCE 751 AA; 85802 MW; E216A3E378EE1F5B CRC64;
MSLRRLDQDY ALEERGRFFI PSETEGDWDV DEHVDHRQLV LLKAEALASE NRLKEAVDMF
AMALRYGPVR PEQLSSLVGC VLRNFKKKSE ESPARSEPNW TQDCELDCPG CHCFIAEPVT
VTCGHTYCRR CLQHSTFSQC KVCNEDIRRR PGEPRLNVIL CGLLDKWFPE DVKRTKYLGE
AESLLKSKQY DKAIALTSRL LDYGSSNMWV QICHAEAHRG LKHHRQALEI WESCLTVSPF
PEGYFQKAKI LQEMGHVDES LQVFLQCLAL DENFHQAKRE VELILHDLLA PASDNVKVGL
RETTHNTCSH LRSKTLVSEN QEQNQQIQMQ NQHQSDMWTT SAQLLPKTAE KAGRSESLER
SGLSRAHSLR IHGIGGVVEE GLKRVSSAPQ LGDPDKGALL KRKLSVSEAG PGIAHSHSTK
CKKQLVTASA ATPVVMEEAK SHQTLPKNLL DPNDFECSLC MRLFYQPVTT PCGHTFCTNC
LERCLDHNPQ CPLCKESLKE YLAFRKYTVT QVLDNIIKQH LPKEHSERVK LHAEETKELS
DLTKNVPIFV CTMAYPTVPC PLHVFEPRYR LMIRRCMETG TRQFGMCISD PQKGFVDHGC
MLQIRSVHFL PDGRSVVDTI GGKRFHVLSR GMRDGYCIAN IEYLQDTKVN DEEDLKKLQV
LHDQVYDQAR KWFQNLENRF RNQILQHFGP MPEREADIQA TPNGPACCWW LLAVLPVDPR
YQLSVLSMTT LKERLVKIQH ILTYLQNLPS K
//
