ID F1QP25_DANRE Unreviewed; 590 AA.
AC F1QP25; A0A8M1PBN3;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Transcriptional activator Myb isoform 2 {ECO:0000313|RefSeq:NP_571341.2};
DE SubName: Full=V-myb avian myeloblastosis viral oncogene homolog {ECO:0000313|Ensembl:ENSDARP00000070207};
GN Name=myb {ECO:0000313|Ensembl:ENSDARP00000070207,
GN ECO:0000313|RefSeq:NP_571341.2, ECO:0000313|ZFIN:ZDB-GENE-991110-14};
GN Synonyms=c-myb {ECO:0000313|RefSeq:NP_571341.2}, cmyb
GN {ECO:0000313|RefSeq:NP_571341.2};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000070207};
RN [1] {ECO:0000313|RefSeq:NP_571341.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571341.2};
RX PubMed=9700456;
RA Trede N.S., Zon L.I.;
RT "Development of T-cells during fish embryogenesis.";
RL Dev. Comp. Immunol. 22:253-263(1998).
RN [2] {ECO:0000313|RefSeq:NP_571341.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571341.2};
RX PubMed=9671819;
RA Kwok C., Korn R.M., Davis M.E., Burt D.W., Critcher R., McCarthy L.,
RA Paw B.H., Zon L.I., Goodfellow P.N., Schmitt K.;
RT "Characterization of whole genome radiation hybrid mapping resources for
RT non-mammalian vertebrates.";
RL Nucleic Acids Res. 26:3562-3566(1998).
RN [3] {ECO:0000313|RefSeq:NP_571341.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571341.2};
RX PubMed=11830566;
RA Liao E.C., Trede N.S., Ransom D., Zapata A., Kieran M., Zon L.I.;
RT "Non-cell autonomous requirement for the bloodless gene in primitive
RT hematopoiesis of zebrafish.";
RL Development 129:649-659(2002).
RN [4] {ECO:0000313|RefSeq:NP_571341.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571341.2};
RX PubMed=11934867;
RA Kalev-Zylinska M.L., Horsfield J.A., Flores M.V., Postlethwait J.H.,
RA Vitas M.R., Baas A.M., Crosier P.S., Crosier K.E.;
RT "Runx1 is required for zebrafish blood and vessel development and
RT expression of a human RUNX1-CBF2T1 transgene advances a model for studies
RT of leukemogenesis.";
RL Development 129:2015-2030(2002).
RN [5] {ECO:0000313|RefSeq:NP_571341.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571341.2};
RX PubMed=14579373; DOI=10.1002/dvdy.10388;
RA Kalev-Zylinska M.L., Horsfield J.A., Flores M.V., Postlethwait J.H.,
RA Chau J.Y., Cattin P.M., Vitas M.R., Crosier P.S., Crosier K.E.;
RT "Runx3 is required for hematopoietic development in zebrafish.";
RL Dev. Dyn. 228:323-336(2003).
RN [6] {ECO:0000313|Ensembl:ENSDARP00000070207}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000070207};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [7] {ECO:0000313|Ensembl:ENSDARP00000070207, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000070207};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [8] {ECO:0000313|RefSeq:NP_571341.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571341.2};
RX PubMed=31300417;
RA De La Garza A., Cameron R.C., Gupta V., Fraint E., Nik S., Bowman T.V.;
RT "The splicing factor Sf3b1 regulates erythroid maturation and proliferation
RT via TGFbeta signaling in zebrafish.";
RL Blood Adv. 3:2093-2104(2019).
RN [9] {ECO:0000313|RefSeq:NP_571341.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571341.2};
RX PubMed=31042481;
RA Xue Y., Liu D., Cui G., Ding Y., Ai D., Gao S., Zhang Y., Suo S., Wang X.,
RA Lv P., Zhou C., Li Y., Chen X., Peng G., Jing N., Han J.J., Liu F.;
RT "A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-
RT dimensional RNA-Seq Analysis.";
RL Cell Rep. 27:1567-1578(2019).
RN [10] {ECO:0000313|RefSeq:NP_571341.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571341.2};
RX PubMed=31064769; DOI=10.1242/dmm.035790;
RA Gjini E., Jing C.B., Nguyen A.T., Reyon D., Gans E., Kesarsing M.,
RA Peterson J., Pozdnyakova O., Rodig S.J., Mansour M.R., Joung K., Look A.T.;
RT "Disruption of asxl1 results in myeloproliferative neoplasms in zebrafish.
RT .";
RL Dis. Model. Mech. 12:dmm035790-dmm035790(2019).
RN [11] {ECO:0000313|RefSeq:NP_571341.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571341.2};
RX PubMed=31015398;
RA Liu Z., Tu H., Kang Y., Xue Y., Ma D., Zhao C., Li H., Wang L., Liu F.;
RT "Primary cilia regulate hematopoietic stem and progenitor cell
RT specification through Notch signaling in zebrafish.";
RL Nat. Commun. 10:1839-1839(2019).
RN [12] {ECO:0000313|RefSeq:NP_571341.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571341.2};
RX PubMed=31073223;
RA Stanic K., Reig G., Wichmann I.A., Opazo J.C., Owen G.I., Corvalan A.H.,
RA Concha M.L., Amigo J.D.;
RT "The Reprimo gene family member, reprimo-like (rprml), is required for
RT blood development in embryonic zebrafish.";
RL Sci. Rep. 9:7131-7131(2019).
RN [13] {ECO:0000313|RefSeq:NP_571341.2}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571341.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; BX927365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CT573377; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_571341.2; NM_131266.2.
DR Ensembl; ENSDART00000075726; ENSDARP00000070207; ENSDARG00000053666.
DR Ensembl; ENSDART00000075726.5; ENSDARP00000070207.4; ENSDARG00000053666.7.
DR GeneID; 30519; -.
DR AGR; ZFIN:ZDB-GENE-991110-14; -.
DR CTD; 4602; -.
DR ZFIN; ZDB-GENE-991110-14; myb.
DR HOGENOM; CLU_015440_2_2_1; -.
DR OrthoDB; 20023at2759; -.
DR Proteomes; UP000000437; Alternate scaffold 23.
DR Proteomes; UP000000437; Chromosome 23.
DR Bgee; ENSDARG00000053666; Expressed in granulocyte and 17 other cell types or tissues.
DR GO; GO:0000785; C:chromatin; IDA:ZFIN.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:ZFIN.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:ZFIN.
DR GO; GO:0043009; P:chordate embryonic development; IMP:ZFIN.
DR GO; GO:0060271; P:cilium assembly; IMP:ZFIN.
DR GO; GO:0060216; P:definitive hemopoiesis; IMP:ZFIN.
DR GO; GO:0001654; P:eye development; IMP:ZFIN.
DR GO; GO:0035701; P:hematopoietic stem cell migration; IGI:ZFIN.
DR GO; GO:0030097; P:hemopoiesis; TAS:ZFIN.
DR GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045658; P:regulation of neutrophil differentiation; IMP:ZFIN.
DR CDD; cd00167; SANT; 3.
DR Gene3D; 1.10.10.60; Homeodomain-like; 3.
DR InterPro; IPR015395; C-myb_C.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR012642; Tscrpt_reg_Wos2-domain.
DR PANTHER; PTHR45614; MYB PROTEIN-RELATED; 1.
DR PANTHER; PTHR45614:SF296; MYB-LIKE DNA-BINDING DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF09316; Cmyb_C; 1.
DR Pfam; PF07988; LMSTEN; 1.
DR Pfam; PF00249; Myb_DNA-binding; 3.
DR SMART; SM00717; SANT; 3.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS51294; HTH_MYB; 3.
DR PROSITE; PS50090; MYB_LIKE; 3.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 35..86
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT DOMAIN 35..86
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT DOMAIN 87..142
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT DOMAIN 87..138
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT DOMAIN 139..189
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT DOMAIN 143..193
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT REGION 338..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 590 AA; 66967 MW; 6DEC7B05CA98D9E4 CRC64;
MARRHRHSVY SSDEDDDDVE IYDHDYDGPH AKTGKRHLGK TRWTREEDEK LKRLVEHHGS
EDWKVIASFL PNRTDVQCQH RWQKVLNPEL IKGPWTKEED QRVIELVQKY GPKRWSVIAK
HLKGRIGKQC RERWHNHLNP EVKKTSWTEE EDQIIYQAHE KLGNRWAEIA KLLPGRTDNA
IKNHWNSTMR RKVEQEGYLQ HAAKVSPTPL NNSYSKPHLL NYNHTPSNTS MPASSMSNQY
PYYTESSRVP FPLALQLNIL NFPQHGTAAI QRHYSDEDPE KEKRVKEIEM LLMSTENELK
GQQALPISMN GYGGWNRGSL ADSSVGIVVS VPAPSLEQGC LPEESAHGNT NSPNNDSSST
LPEFIDAIDS FFNASVSPDS DSQNIPVTPS PVCSQKALQQ DLALRPQKEN ELFRTPNLRR
SIMECSPRTP TPFKSTLTMQ DSKYGPLKRV HSPSLDSGVV GTIKQEPQEC EISVGGVHLD
QPPLKKIKQE VESVCLQWEG QDLHTQLFPS NGPAHDMPDL LTSSVLMLPN TEKTEDGHKA
AQLPRRPIGS PLQQLNTWEQ VLCGKTEEQT IPSEATHKYL SNYSSRALVI
//
