GenomeNet

Database: UniProt
Entry: F1QS14_DANRE
LinkDB: F1QS14_DANRE
Original site: F1QS14_DANRE 
ID   F1QS14_DANRE            Unreviewed;       605 AA.
AC   F1QS14; A0A8M2B3E1;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 3.
DT   24-JAN-2024, entry version 78.
DE   RecName: Full=Kinesin light chain {ECO:0000256|RuleBase:RU367020};
GN   Name=Kns2 {ECO:0000313|RefSeq:XP_005156692.1};
GN   Synonyms=zgc:66299 {ECO:0000313|RefSeq:XP_005156692.1};
GN   OrderedLocusNames=klc1a {ECO:0000313|Ensembl:ENSDARP00000011544,
GN   ECO:0000313|RefSeq:XP_005156692.1,
GN   ECO:0000313|ZFIN:ZDB-GENE-040426-1599};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000011544};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000011544}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000011544};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000011544, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000011544};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RG   Genome Reference Consortium Zebrafish;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA   Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA   Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA   Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA   Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA   Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA   Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA   Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA   Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA   Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA   Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA   Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA   Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA   Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA   Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA   Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA   Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA   Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA   Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA   Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA   Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA   Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [3] {ECO:0000313|RefSeq:XP_005156692.1}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005156692.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Kinesin is a microtubule-associated force-producing protein
CC       that play a role in organelle transport.
CC       {ECO:0000256|RuleBase:RU367020}.
CC   -!- SUBUNIT: Oligomeric complex composed of two heavy chains and two light
CC       chains. {ECO:0000256|RuleBase:RU367020}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|RuleBase:RU367020}.
CC   -!- SIMILARITY: Belongs to the kinesin light chain family.
CC       {ECO:0000256|ARBA:ARBA00009622, ECO:0000256|RuleBase:RU367020}.
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DR   EMBL; BX569782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX890571; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005156692.1; XM_005156635.4.
DR   STRING; 7955.ENSDARP00000011544; -.
DR   Ensembl; ENSDART00000008987; ENSDARP00000011544; ENSDARG00000009796.
DR   Ensembl; ENSDART00000008987.9; ENSDARP00000011544.9; ENSDARG00000009796.11.
DR   GeneID; 393928; -.
DR   CTD; 393928; -.
DR   ZFIN; ZDB-GENE-040426-1599; klc1a.
DR   HOGENOM; CLU_019953_0_0_1; -.
DR   OMA; KHHDLSA; -.
DR   OrthoDB; 5392083at2759; -.
DR   Reactome; R-DRE-2132295; MHC class II antigen presentation.
DR   Reactome; R-DRE-5625970; RHO GTPases activate KTN1.
DR   Reactome; R-DRE-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR   Reactome; R-DRE-983189; Kinesins.
DR   Proteomes; UP000000437; Chromosome 13.
DR   Bgee; ENSDARG00000009796; Expressed in brain and 23 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005871; C:kinesin complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-UniRule.
DR   GO; GO:0019894; F:kinesin binding; IBA:GO_Central.
DR   GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR002151; Kinesin_light.
DR   InterPro; IPR015792; Kinesin_light_repeat.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR45783; KINESIN LIGHT CHAIN; 1.
DR   PANTHER; PTHR45783:SF7; KINESIN LIGHT CHAIN 1; 1.
DR   Pfam; PF13374; TPR_10; 2.
DR   Pfam; PF13424; TPR_12; 2.
DR   PRINTS; PR00381; KINESINLIGHT.
DR   SMART; SM00028; TPR; 5.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS01160; KINESIN_LIGHT; 1.
DR   PROSITE; PS50005; TPR; 2.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU367020};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW   ECO:0000256|RuleBase:RU367020};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|RuleBase:RU367020};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175,
KW   ECO:0000256|RuleBase:RU367020};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:F1QS14};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   REPEAT          260..293
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          302..335
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REGION          161..207
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          518..605
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          94..156
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        161..183
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        518..533
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        554..573
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        574..592
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   605 AA;  68075 MW;  CFDB873CCF0928E9 CRC64;
     MREDMSSVLC VKETEGQGDL GEKLSQDELL CRTREVMQGL EALRAEHQAI LEGLMGTLRC
     LKQSQEGRAV EEKTAMIQRS MEMLELGLSE AQVMMALSGH LSAVEAEKQK LRAQVRRLCQ
     ENQWLRDELA GTQQRLQKSE QSVAQLEEEK KHLEFMNQLK KYDQDLSPSD DKDSDSSRET
     LDDLFPDEQD EPGPGIQPPH SSAVAAAQQG GYEIPARLRT LHNLVIQYAS QGRYEVAVPL
     CKQALEDLEK TSGHDHPDVA TMLNILALVY RDQNKYKEAA NLLNDALAIR EKTLGRDHPA
     VAATLNNLAV LYGKRGKYKE AEPLCKRALE IREKVLGKDH PDVAKQLNNL ALLCQNQGKY
     EEVEYYYQRA LEIYQTKLGP DDPNVAKTKN NLASCYLKQG KFKQAETLYK EILTRAHERE
     FGSVDDENKP IWMHAEEREE QSKIKQKDGT PFGEYGGWYK ACKVDSPTVT TTLKNLGALY
     RRQGKFEAAE TLEEAALRSR KQGLDTAHKQ RVAEVLGDPE VREKQRSRES LTSDTVKYES
     GPDGGEEVSM SVEWNGDGSG SLKRSGSFSK LRASIRRSSE KLVRKLKGGG VRENEPKNPG
     NEIIV
//
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