ID F1QTJ4_DANRE Unreviewed; 1615 AA.
AC F1QTJ4; A0A8M3APK3;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=Low density lipoprotein receptor-related protein 5 {ECO:0000313|Ensembl:ENSDARP00000108864};
DE SubName: Full=Low-density lipoprotein receptor-related protein 5 isoform X1 {ECO:0000313|RefSeq:XP_009296098.1};
GN Name=lrp5 {ECO:0000313|Ensembl:ENSDARP00000108864,
GN ECO:0000313|RefSeq:XP_009296098.1,
GN ECO:0000313|ZFIN:ZDB-GENE-050518-2};
GN Synonyms=LRP6 {ECO:0000313|RefSeq:XP_009296098.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000108864};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000108864}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000108864};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000108864, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000108864};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_009296098.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_009296098.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; BX572619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01054500; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01054501; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; FO704576; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; FO704597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009296098.1; XM_009297823.3.
DR STRING; 7955.ENSDARP00000108864; -.
DR PaxDb; 7955-ENSDARP00000108864; -.
DR Ensembl; ENSDART00000121724.4; ENSDARP00000108864.1; ENSDARG00000006921.12.
DR Ensembl; ENSDART00000186758.1; ENSDARP00000146818.1; ENSDARG00000006921.12.
DR GeneID; 568518; -.
DR AGR; ZFIN:ZDB-GENE-050518-2; -.
DR CTD; 4041; -.
DR ZFIN; ZDB-GENE-050518-2; lrp5.
DR eggNOG; KOG1215; Eukaryota.
DR HOGENOM; CLU_002489_0_0_1; -.
DR OMA; HTPCEDN; -.
DR OrthoDB; 3107655at2759; -.
DR TreeFam; TF315253; -.
DR Reactome; R-DRE-3772470; Negative regulation of TCF-dependent signaling by WNT ligand antagonists.
DR Reactome; R-DRE-4641262; Disassembly of the destruction complex and recruitment of AXIN to the membrane.
DR Reactome; R-DRE-4641263; Regulation of FZD by ubiquitination.
DR Proteomes; UP000000437; Chromosome 25.
DR Bgee; ENSDARG00000006921; Expressed in liver and 39 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0042813; F:Wnt receptor activity; IBA:GO_Central.
DR GO; GO:0017147; F:Wnt-protein binding; IBA:GO_Central.
DR GO; GO:0035676; P:anterior lateral line neuromast hair cell development; IMP:ZFIN.
DR GO; GO:0030282; P:bone mineralization; IMP:ZFIN.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IMP:ZFIN.
DR GO; GO:0051216; P:cartilage development; IMP:ZFIN.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IMP:ZFIN.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0031101; P:fin regeneration; IMP:ZFIN.
DR GO; GO:0001889; P:liver development; IMP:ZFIN.
DR GO; GO:0001755; P:neural crest cell migration; IMP:ZFIN.
DR GO; GO:0032474; P:otolith morphogenesis; IMP:ZFIN.
DR GO; GO:0035677; P:posterior lateral line neuromast hair cell development; IMP:ZFIN.
DR GO; GO:0030500; P:regulation of bone mineralization; IMP:ZFIN.
DR GO; GO:0045124; P:regulation of bone resorption; IMP:ZFIN.
DR GO; GO:0030111; P:regulation of Wnt signaling pathway; IMP:ZFIN.
DR GO; GO:0007605; P:sensory perception of sound; IMP:ZFIN.
DR CDD; cd00112; LDLa; 3.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 3.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR46513:SF16; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF14670; FXa_inhibition; 4.
DR Pfam; PF00057; Ldl_recept_a; 3.
DR Pfam; PF00058; Ldl_recept_b; 10.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00192; LDLa; 3.
DR SMART; SM00135; LY; 20.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57424; LDL receptor-like module; 3.
DR SUPFAM; SSF63825; YWTD domain; 4.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 3.
DR PROSITE; PS51120; LDLRB; 13.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|RefSeq:XP_009296098.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1QTJ4};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_009296098.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1388..1408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 125..167
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 168..211
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 212..254
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 303..342
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 390..432
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 433..475
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 476..519
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 520..562
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 609..646
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 692..734
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 735..777
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 778..820
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 821..862
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 910..947
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 1081..1125
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1126..1168
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 1218..1262
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 1299..1335
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REGION 1007..1030
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1473..1506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1565..1615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1009..1026
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1473..1494
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1582..1596
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1601..1615
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1282..1297
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1300..1312
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1307..1325
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1319..1334
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1338..1350
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1345..1363
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1357..1372
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1615 AA; 180721 MW; E49F113A4308F33C CRC64;
MELKPGALAM EILLLELLLC CSLTVIRGSP LLLFANRRDV RLVDVEVGRS ESAVVVSDLE
DAAAVDFLFS EGLIFWTDVS EEAIKQTYYN LSTNSMKEAT LGKGQTVVVS GLDSPDGLAC
DWLGHKLYWT DSETNRIEVA NLDGTSRKVL FWQDLDQPRA IALNPSHRYM YWTDWGEEPR
IERAGMDGSN RQIIVQKQIY WPNGLTIDLD EQKLYWADAK LSFIHRANLD GTSREAVVEG
SLTHPFALTL YDETLYWTDW QTRSIHACNK HSGEKHREIL NGIYSPMDIQ VLGQERQPNI
QTPCSERNGG CSHLCLLSPI PPFYSCACPT GVKLKEDGKT CRPGAEQVLL LARRTDLRRI
SLDLPDFTDI VLQVNDIRHA IAIDYDPVEG YVYWTDDELR AIRRARIDGS DAQTLITNEI
NHPDGIAVDW VARNLYWTDT GTDRIEVTRL NGTSRRVLIS ENLDEPRAIV LDPINGYMYW
TDWGELPKIE RANLDGTDRV VLLNTSLGWP NGLAIDYIAG KLYWGDAKTD KIEVINVDGT
NRMTILEDKL PHIFGFTLLG EYIYWTDWQR RSIERVHIAN STREVIVEQL PDLMGLKATK
VMEAEGTNGC AENNGGCSHL CFHRPQGLSC ACPMGLELLS DLRTCVVPEA FLLFTNRADI
RSISLGTNSN DVPIPLTGVK EASALDFDVL ENRIYWTDVS TKTISRAFMN GSSVEPVIEF
GLDYPEGMAV DWMGRNLYWA DTGTNRIEVA RLDGQYRQVL VCKDLDNPRS LALDPANGYM
YWTEWGGRPR IARAHMDGSN IVTLVDKVGR ANGLTIDYID QRLYWTDLDT CMIESTNMQG
LQREIVADDL PHPFGLTQYR DYIYWTDWNL RSIERADKRS GLNRTVVQGH LEYVMDILVF
HSSRQDGAND CSQNNGQCAH LCLASPSGAQ CRCASHYTLE ANGRNCSSPS SFLLFSQKSS
ISRMVLGEQS PDMILPIHVM KNLRAISFDP LERLVYWVDG RQNIRRSRDD GTQASTVMTP
NSDHPKQPHD LSLDPYSRTV YWTCETTNTI NIHRMDGHII GEVLKDDVDK PRAIVVNAEK
GYMYFTTVQE RSAKIEGASL DGTERESLFT TSLIRPVALA LDNKLGKLFW VDADLKRIES
SDLSGANRIV LQDSNILQPV GLTVLGDHLY WIDKQQQMIE RVDKLTGEKR TRIQGRLQYL
TGIHAVQYME TDEFATHPCS RDNGGCSHIC IAKGDGTPRC SCPMHLVLLQ NLLSCGEPPT
CSSEQFTCAT GEIDCIPMAW RCDGIAECAD NSDEMNCPIC SKLQFQCDKG QCVDIQVRCN
GEPDCADGSD EQDCETICLS NQFRCGNSQC ILKKQQCDSF PDCTDESDER FCDFPPPPND
LPRHTSTIGP VIGIILSVFV MGGMCFVCQR VVCRHYKGPN GGFPHEYISG TPHVPLNFIA
PTNSQHGKGI SCGKSMMSSV SLMGSSSSGA PLYDRNHVTG ASSSSSSSTK GAFYPQMLNP
PPSPATDRSL YNAEVFYSSN SPSTTRSYRP YLMRGVAPPT TPCSTDVCDS DYTTSRWKSN
KYYMDLNSDS DPYPPPPTPR SQYMSAEESC PPSPSTERSY FHLCPPPPSP CTDSS
//
