ID F1QYL4_DANRE Unreviewed; 1205 AA.
AC F1QYL4; A0A8M2B2T7;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 3.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=BK channel {ECO:0000256|ARBA:ARBA00029579};
DE AltName: Full=Slowpoke homolog {ECO:0000256|ARBA:ARBA00033447};
GN Name=kcnma1a {ECO:0000313|Ensembl:ENSDARP00000105964,
GN ECO:0000313|RefSeq:XP_005156727.1,
GN ECO:0000313|ZFIN:ZDB-GENE-070202-9};
GN Synonyms=kcnma1 {ECO:0000313|RefSeq:XP_005156727.1}, si:ch211-39f22.2
GN {ECO:0000313|RefSeq:XP_005156727.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000105964};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000105964}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000105964};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000105964, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000105964};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_005156727.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005156727.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the potassium channel family. Calcium-activated
CC (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
CC {ECO:0000256|ARBA:ARBA00008648}.
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DR EMBL; AL645926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL954192; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX469897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CT025847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005156727.1; XM_005156670.4.
DR Ensembl; ENSDART00000122557; ENSDARP00000105964; ENSDARG00000079840.
DR Ensembl; ENSDART00000122557.3; ENSDARP00000105964.3; ENSDARG00000079840.6.
DR GeneID; 568554; -.
DR AGR; ZFIN:ZDB-GENE-070202-9; -.
DR CTD; 568554; -.
DR ZFIN; ZDB-GENE-070202-9; kcnma1a.
DR OrthoDB; 2902976at2759; -.
DR TreeFam; TF314283; -.
DR Proteomes; UP000000437; Chromosome 13.
DR Bgee; ENSDARG00000079840; Expressed in retina and 16 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR048735; Slowpoke-like_C.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF42; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1; 1.
DR Pfam; PF03493; BK_channel_a; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF21014; Slowpoke_C; 1.
DR PRINTS; PR01449; BKCHANNELA.
DR PRINTS; PR00169; KCHANNEL.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303,
KW ECO:0000313|RefSeq:XP_005156727.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 56..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 188..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 151..367
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 517..604
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
FT DOMAIN 973..1093
FT /note="Ca2+-activated K+ channel Slowpoke-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21014"
FT REGION 676..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1103..1164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1103..1134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1135..1164
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1205 AA; 135563 MW; 98F655A4AE15227D CRC64;
MLAVADGNGS YGSSSSRMSN NINFNKNPDS SVSISKMDVI IPFTPDVPCD NNGQRMWWAF
LASSMVTFFG GLFIILLWRT LKYLWTVCCH CNIKNKEAQK VNNPITIQAD GTTKTGNEKE
EAPASEVGWM TSVKDWAGVM ISAQTLTGRV LVVLVFALSI GALGIYFIDS SDPIESCQNF
YKDFTLQIDM AFNVFFLLYF GLRFIAANDK LWFWLEVNSV VDFFTVPPVF VSVYLNRSWL
GLRFLRALRL IQFSEILQFL NILKTSNSIK LVNLCSIFIS TWLTAAGFIH LVENSGDPWE
NFQNSQPLSY WECVYLLMVT MSTVGYGDVY ARTTLGRLFM VFFILGGLAM FASYVPEIIE
LIGNRKKYGG SYSAVNGRKH IVVCGHITLE SVSNFLKDFL HKDRDDVNVE IVFLHNISPN
LELEALFKRH FTQVEFYQGS VLNPHDLARV KIESADACLI LANKYCADPD AEDASNIMRV
ISIKNYHPKI RIITQMLQYH NKAHLLNIPS WNWKEGDDAI CLAELKAGFI AQSCLAQGLS
TMLANLFSMR SYIKIEEDTW QKYYLEGVAN EMYTEYLSSA FVGLSFPTVC ELCYVKLKLL
LIAIEYKSEQ RESRSRKRIL INPGNHVKMQ EGTLGFFIAS DAKEVKRAFF YCKACHDDIT
DPKRIKKCGC KRIEDEHPST LSPKKKQRNG GMRNSPNCSP KMMRHDPLLI PGNEQIESMD
ANVKRYDSTG MFHWCPSKEI EKVILTRSEA SMTVLSGHVV VCIFGDVTSA LVGLRNLVMP
LRASNFHYHE LKPIVFVGSL DYLRREWETL HNFPKVFILP GTPLSRADLR AVNINLCDMC
VILSANQNNI DDASLQDKEC ILASLNIKSM QFDDSIGVLQ ANSQGFTPPG MDRSSPDNSP
VHGLVRQASV TTGSNIPIIT ELVNDSNVQF LDQDDDDDPD TELYLTQPFA CGTAFAVSVL
DSLMSATYFN DNILTLIRTL VTGGATPELE ALLAEENALR GGYSTPQTLA NRDRCRVAQL
ALYDGPFADL GDGGCYGDLF CKALKTYNML CFGIYRLRDA HLGAPSQCTK RYVITNPPYE
FEMVPTDLIF CLMQFDHNAG QSRASLSHSS HSSHSSSKKS SSVHSIPATN RQNRSSKARE
ARDKQNATRM NRMGPEKRWF TDEAENAYPR NIQIKPMSTH MANQVNQYKS TSSLIPPIRE
VEDEC
//
