ID F1QYX6_DANRE Unreviewed; 1583 AA.
AC F1QYX6; A0A8M3B2L4;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Transient receptor potential cation channel subfamily M member 3 isoform X15 {ECO:0000313|RefSeq:XP_009299836.1};
DE SubName: Full=Transient receptor potential cation channel, subfamily M, member 3 {ECO:0000313|Ensembl:ENSDARP00000082466};
GN Name=trpm3 {ECO:0000313|Ensembl:ENSDARP00000082466,
GN ECO:0000313|RefSeq:XP_009299836.1,
GN ECO:0000313|ZFIN:ZDB-GENE-060531-95};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000082466};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000082466}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000082466};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000082466, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000082466};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_009299836.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_009299836.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; BX323080; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX511001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009299836.1; XM_009301561.3.
DR Ensembl; ENSDART00000088033; ENSDARP00000082466; ENSDARG00000039181.
DR Ensembl; ENSDART00000088033.5; ENSDARP00000082466.4; ENSDARG00000039181.9.
DR GeneID; 565807; -.
DR AGR; ZFIN:ZDB-GENE-060531-95; -.
DR CTD; 80036; -.
DR ZFIN; ZDB-GENE-060531-95; trpm3.
DR HOGENOM; CLU_001390_4_1_1; -.
DR OrthoDB; 201873at2759; -.
DR Reactome; R-DRE-3295583; TRP channels.
DR Proteomes; UP000000437; Chromosome 5.
DR Bgee; ENSDARG00000039181; Expressed in choroid plexus and 19 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005261; F:monoatomic cation channel activity; IBA:GO_Central.
DR GO; GO:0098655; P:monoatomic cation transmembrane transport; IBA:GO_Central.
DR GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR Gene3D; 1.20.5.1010; TRPM, tetramerisation domain; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR InterPro; IPR032415; TRPM_tetra.
DR InterPro; IPR037162; TRPM_tetra_sf.
DR PANTHER; PTHR13800:SF7; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 3; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR Pfam; PF16519; TRPM_tetra; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_009299836.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 620..638
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 733..752
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 800..818
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 830..848
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 869..889
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 947..972
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..265
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 742..981
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1073..1127
FT /note="TRPM tetramerisation"
FT /evidence="ECO:0000259|Pfam:PF16519"
FT REGION 1163..1189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1228..1253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1427..1481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1525..1583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1447..1471
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1583 AA; 179169 MW; BE7419630E936E31 CRC64;
MYVRVSYDTK PDLLLHLMTK EWQLELPKLL ISVHGGLQNF ELQPKLKQVF GKGLIKAAMT
TGAWIFTGGV NTGVIRHVGD ALKDHASKSR GKICTIGIAP WGIVENQEDL VGKDVVRPYQ
TMSNPLSKLT VLNSLHSHFI LADNGTTGKY GAEVKLRRQL EKHISLQKIN TRIGQGVPVV
ALIVEGGPNV ISIVLEYLRD TPPVPVVVCD GSGRASDILA FGHKYSEEGG IINESLRDQL
LVTIQKTFTY SRTQAQHLFI ILMECMKKKE LITVFRMGSE GHQDIDLAIL TALLKGANAS
APDQLSLALA WNRVDIARSQ IFIYGQQWPV GSLEQSMLDA LVLDRVDFVK LLIENGVSMH
RFLTLSRLEE LYNTRHGPSN TLYHLVRDVK KGNLPPDYRI SLIDIGLVIE YLMGGAYRCN
YTRKRFRTLY HNLFGPKRPK ALKLLGMEDD MPIRRGRQKT TRKREEEVDI DLDDPEINHF
PFPFHELMVW AVLMKRQKMA LFFWQHGEEA MAKALVACKL CKAMAHEASE NDMVDDISQE
LNQNSREFGQ LAVELLDQSY KQDEQMAMKL LTYELKNWSN ATCLQLAVAA KHRDFIAHTC
SQMLLTDMWM GRLRMRKNSG LKVILGLLLP PSILSLEFKN KDEMSYMPQD QDTYLQEKDV
DEPEKQAKEK EEEDMEFTVR SYCETQYNSV AMLGNVSSEA SRKKQVEEVQ NRHRLIPLGR
KIYEFYNAPI VKFWFHTLAY VGYLMLFNYI VLVKMDLWPS PQEWIVIAYI FTNGIEKMRE
ILMSEPGKLL QKVKVWLQEY WNITDLMAIL IFSIGMVLRL QDPPLMSYGR VIYCVNIIYW
YIRLLDIFGV NKYLGPYVMM IGKMMIDMMY FVIIMLVVLM SFGVARQAIL NPNEDPSWML
ARNIFFMPYW MIYGEVFADQ IDPPCGQNIT TEEGVVMPLP PCKTGAWIVP AIMACYLLVA
NILLVNLLIA VFNNTFFEVK SISNQVWKFQ RYQLIMTFHE RPVLPPPLII FSHITMVLKH
LCCRWRKHDE DERDYGLKLF ITEDELKKVH DFEEQCMEEY FREKDDRFNS SNDERIRVTS
ERVENMAMRL EEVNEREHFM KASLQTVDIR LAQMEEMIGR IAVALERVAG MDRGEVNKAR
SRTSSDCTDT NYILRQSSFN SQEGNSYRLQ ESLEQGGDES ISPTSPTALA PRVRSHSFYV
SHSSKDRSGA DRGEGFFKDK LFSLHRANSS QSVSSGAGPK ESKPTPLNTL SVQQQLRPSS
CIDIYVSASE DVPPTESFLD SVRTVPTLAR DSSLHSEIME AVLSGGRDCS GRAGGSERQS
DGTVLFEDSA AADLSLCSAH LLPDSLPPWD LDPSPPPSAG VLERSKSSRF LSTAGPLFLD
EPHLVKSHSL MFTSRGYYGG MGVQVKAAEY TSITDCIDTR CVSTPYPVPE RSDSPGGSFT
FDKPQDLGVS HPERDAELSH AESDLEEPAE GSGDTCKVGQ SSSSGVIGAD LGLGLALGPF
CSPISRLERA NSCSSSEESH SNIYSRKSFS ISERMDKGRG SSRNPFQKAR TGARLEGKTD
SLSMRKMAKP SAFRSFDSRH NYT
//
