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Database: UniProt
Entry: F1R1D6_DANRE
LinkDB: F1R1D6_DANRE
Original site: F1R1D6_DANRE 
ID   F1R1D6_DANRE            Unreviewed;      1458 AA.
AC   F1R1D6;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 3.
DT   31-JUL-2019, entry version 56.
DE   SubName: Full=Calmodulin-regulated spectrin-associated protein 1a {ECO:0000313|Ensembl:ENSDARP00000093418};
GN   Name=camsap1a {ECO:0000313|Ensembl:ENSDARP00000093418,
GN   ECO:0000313|ZFIN:ZDB-GENE-060518-4};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000093418, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000093418}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000093418};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000093418, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000093418,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
CC   -!- DOMAIN: The CKK domain binds microtubules. {ECO:0000256|PROSITE-
CC       ProRule:PRU00841}.
CC   -!- SIMILARITY: Belongs to the CAMSAP1 family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00841}.
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DR   EMBL; CR388125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001159727.1; NM_001166255.1.
DR   STRING; 7955.ENSDARP00000093418; -.
DR   PaxDb; F1R1D6; -.
DR   Ensembl; ENSDART00000102643; ENSDARP00000093418; ENSDARG00000019208.
DR   GeneID; 402833; -.
DR   KEGG; dre:402833; -.
DR   CTD; 402833; -.
DR   ZFIN; ZDB-GENE-060518-4; camsap1a.
DR   eggNOG; KOG3654; Eukaryota.
DR   eggNOG; ENOG4111D0B; LUCA.
DR   GeneTree; ENSGT00950000182975; -.
DR   InParanoid; F1R1D6; -.
DR   KO; K17493; -.
DR   TreeFam; TF315529; -.
DR   Proteomes; UP000000437; Chromosome 21.
DR   Bgee; ENSDARG00000019208; Expressed in 13 organ(s), highest expression level in mature ovarian follicle.
DR   ExpressionAtlas; F1R1D6; baseline.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-UniRule.
DR   GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR   GO; GO:0051011; F:microtubule minus-end binding; IBA:GO_Central.
DR   GO; GO:0030507; F:spectrin binding; IEA:InterPro.
DR   GO; GO:0031122; P:cytoplasmic microtubule organization; IBA:GO_Central.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0007026; P:negative regulation of microtubule depolymerization; IBA:GO_Central.
DR   GO; GO:0031175; P:neuron projection development; IEA:InterPro.
DR   Gene3D; 3.10.20.360; -; 1.
DR   InterPro; IPR032940; CAMSAP.
DR   InterPro; IPR031372; CAMSAP_CC1.
DR   InterPro; IPR022613; CAMSAP_CH.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR038209; CKK_dom_sf.
DR   InterPro; IPR014797; CKK_domain.
DR   InterPro; IPR011033; PRC_barrel-like_sf.
DR   PANTHER; PTHR21595; PTHR21595; 1.
DR   Pfam; PF17095; CAMSAP_CC1; 1.
DR   Pfam; PF11971; CAMSAP_CH; 1.
DR   Pfam; PF08683; CAMSAP_CKK; 1.
DR   SMART; SM01051; CAMSAP_CKK; 1.
DR   SUPFAM; SSF47576; SSF47576; 1.
DR   SUPFAM; SSF50346; SSF50346; 1.
DR   PROSITE; PS50021; CH; 1.
DR   PROSITE; PS51508; CKK; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Microtubule {ECO:0000256|PROSITE-ProRule:PRU00841};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT   DOMAIN      230    341       Calponin-homology (CH).
FT                                {ECO:0000259|PROSITE:PS50021}.
FT   DOMAIN     1323   1457       CKK. {ECO:0000259|PROSITE:PS51508}.
FT   REGION      413    455       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      514    537       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      560    634       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      712    785       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      872    905       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      942   1135       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1156   1245       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1273   1294       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COILED      794    821       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    569    597       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    598    634       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    721    740       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    756    771       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    872    892       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    942    997       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1047   1063       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1156   1224       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   1458 AA;  162640 MW;  5AA29D60F71975B0 CRC64;
     MDVGALAAGD GGPRRADSVE GGLEIAPLEM YDSARAKIEA NLRWLFAKAY GEEHIPEDLR
     DPFYTDQYCV EHIKPPVLCL LLSSELYCRV CGLLLKGDQA SALSSHQAVL QTLARRGISV
     REPDDTPVTH DDLTSTPIKM SAHIPLIDAL MMAYTVEMMP IERVVASVKR FSTFCASKEL
     PFDMEDAALF WINKVVLKTR DLSEKELKVK QPLMDSPCHQ KSPSKWYWKL VPVRYRREHM
     SGHPVPHLAV MEDLMKDICD GAALLAVIHF YCPEYMRLDD ICLKEVPSLS DSVYNIHLLR
     EFSNEYLNRC FYLHTEDLLY GPPVLKNNVM VFIAELFWWF EVVKPDFVKP RDLQEVKDVR
     ASLQPKSSRP LLPISNATKR SFLTPSPSAD SLATAAAPDG CMRYYLHPEE SLSVTNRSPT
     HSPFHPLLPL RQRQQKPTQG DEISELRNRS NSLSRMDGLG LGLGSQLSWT DRKQRPISQM
     EMDWERVCGD NISLARSISK DSLASNVISI TPRHRINGQP LPQTRQCDNQ EEDEEEELLA
     VINPEGAAAS RDGFFLEPLQ PAVLRPNKEK AGISKREESG EGRGQGHEGR SHSSDGRSQG
     RKGAYTPTEC TFNRTFTPIS STDQESSREQ SPGSFFLHSD AECARDSPLG GWEDVISDSE
     FEEDDDIQDV PEQELSKALL MMHAGKKCMG FGEEEESVKL CEDVCIRERD DKEGASGRAS
     PCPSVMSQAS STSTGTGRMT SFAERRRHRV GFPDGCYSTG SSQTTTPDGS ESLHFPADAS
     PGTPSGRPVV ASELVHLRMQ LEEKRRAIEL QKKRMENLSA RQRLQLGKAA FLHVVKKGRS
     DTLPHPLKTE ITFKEKPIAK DDTCVEILKP RRKDSECKET PSEEDKDNRV AAGGGALDEV
     GGEPDLSECS RSIELLNEAI GAIQQQMMQL SFQQDLLMKQ TVQPPQEPSL TKPNTVTPLN
     EQHPETKSRL SVQFTETLST ATKRPPRLSS SRTPRTKPTD LKLSKEANPR PAAKASTPGG
     RTPRAETEEE GVAKEGGRGL KGIIRNTTFR LQESANRRAD SLESPQTELP PVEATLVDAT
     RERSESGGSG KENVPVSSDE NKTKAQLIEV DMSDLAEPSG TEPDGEQKSG LGFFFKDDQK
     AEDELAKKRA AFLLKQQRKA EEARIRKQQL EAESELKRDE ARRKAEEDRV RKEEEKARRE
     LIKQEYLRRK QQELLEEQGA AKPRPRNRRP RPKSLHRAES SCSARKKRKL LKGLCSAPSG
     SSLSLASAAT EGDSVASGGA SSHRGESVES FPILSRNASR NMERDWDNGS TASSITSVAE
     YNGPRLFKEP SAKSNKPIIQ NAIAHCCLAG KVNEAQKNAI LDEIERCESN HLIILFRDGG
     CQFRALYIYS PETEEIIKLK GTGPRAISRK MIDRLYKYSS DRKQFTVIPA KSVSVSVDAL
     TIHSHLWQAK RPSTSKRK
//
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