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Database: UniProt
Entry: F1R1R7_DANRE
LinkDB: F1R1R7_DANRE
Original site: F1R1R7_DANRE 
ID   F1R1R7_DANRE            Unreviewed;       742 AA.
AC   F1R1R7;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   10-OCT-2018, entry version 51.
DE   SubName: Full=Coagulation factor XIII, A1 polypeptide b {ECO:0000313|Ensembl:ENSDARP00000093311};
GN   Name=f13a1b {ECO:0000313|Ensembl:ENSDARP00000093311,
GN   ECO:0000313|ZFIN:ZDB-GENE-030131-9634};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000093311, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000093311}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000093311};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000123898}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000123898};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000093311, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000093311,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [4] {ECO:0000313|Ensembl:ENSDARP00000147730}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000147730};
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC       Note=Binds 1 Ca(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR000459-2};
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DR   EMBL; BX004828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR382283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7955.ENSDARP00000123898; -.
DR   Ensembl; ENSDART00000102535; ENSDARP00000093311; ENSDARG00000036893.
DR   Ensembl; ENSDART00000149510; ENSDARP00000123898; ENSDARG00000036893.
DR   Ensembl; ENSDART00000182530; ENSDARP00000153253; ENSDARG00000036893.
DR   Ensembl; ENSDART00000184049; ENSDARP00000147730; ENSDARG00000036893.
DR   ZFIN; ZDB-GENE-030131-9634; f13a1b.
DR   eggNOG; ENOG410IFMV; Eukaryota.
DR   eggNOG; ENOG410XQEZ; LUCA.
DR   GeneTree; ENSGT00760000119108; -.
DR   OMA; CEEDAVY; -.
DR   OrthoDB; EOG091G030K; -.
DR   TreeFam; TF324278; -.
DR   Reactome; R-DRE-114608; Platelet degranulation.
DR   Reactome; R-DRE-140875; Common Pathway of Fibrin Clot Formation.
DR   Proteomes; UP000000437; Chromosome 7.
DR   Bgee; ENSDARG00000036893; Expressed in 26 organ(s), highest expression level in spleen.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
DR   GO; GO:0072378; P:blood coagulation, fibrin clot formation; IEA:InterPro.
DR   GO; GO:0018149; P:peptide cross-linking; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 3.
DR   Gene3D; 3.90.260.10; -; 1.
DR   InterPro; IPR034810; Factor_XIII_A.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR038765; Papain_like_cys_pep_sf.
DR   InterPro; IPR002931; Transglutaminase-like.
DR   InterPro; IPR036985; Transglutaminase-like_sf.
DR   InterPro; IPR023608; Transglutaminase_animal.
DR   InterPro; IPR008958; Transglutaminase_C.
DR   InterPro; IPR036238; Transglutaminase_C_sf.
DR   InterPro; IPR001102; Transglutaminase_N.
DR   PANTHER; PTHR11590:SF42; PTHR11590:SF42; 1.
DR   Pfam; PF00927; Transglut_C; 2.
DR   Pfam; PF01841; Transglut_core; 1.
DR   Pfam; PF00868; Transglut_N; 1.
DR   PIRSF; PIRSF000459; TGM_EBP42; 1.
DR   SMART; SM00460; TGc; 1.
DR   SUPFAM; SSF49309; SSF49309; 2.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:F1R1R7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT   DOMAIN      325    418       TGc. {ECO:0000259|SMART:SM00460}.
FT   ACT_SITE    333    333       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    392    392       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    415    415       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   METAL       455    455       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       457    457       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       504    504       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       509    509       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
SQ   SEQUENCE   742 AA;  83605 MW;  2D3A3175BD60C0DC CRC64;
     MADQVAPENP TPAAAPTVRP KQRVSHRGRS AGGRASSNQQ EGKVEEFEPF MLMPRGPPPL
     TEYLDIFDVD VLKQPNEVNK QAHHTHLYSS NFLIVRRAQE FQIKITFNRP YKPAEDKFAV
     EFVIGPVPQY SKGTYIPVFP TAKRQSVWSG RVIESSENVV TMGITPSAEC IVGKYMTYIG
     VETPYGIRRT RRDPNTDIYI LFNPWSPADP VFLDDEEERE ECVMNELGII YHGAYDDVSE
     RAWNYGQFEF GVLDACLFVM DKADMPLSNR GDVVKVTRVA SAMLNSRDDD GVLVGNWSGD
     YMYGVPPTSW TGSVEILLDY ANSSGTPVCY AQCWVYAAVF NTFLRCLGIP SRVVTNFFSA
     HDNDGNLKMD IILDENGKLD RNRTKDSIWN YHCWNECYMA RPDLPSGFGG WQVVDATPQE
     TSDGMFRCGP ASVAAIKHGQ ICYPFDAPFV FAEVNSDVVF YRRRKDGILE VVKVNQTHVG
     RMVLTKAVLH SGRRDITNQY KFPEGSPEER RVLEKAEEFG CQREKSSPAL SDVDVEIHSL
     DVNVGENFDV TLQFTNRSDQ RRTADVYITG TVVYYTGVPS GEVVFKTPKV KLEPMQSKEE
     KVLVRSEDYM NKLVEQRNIH FIATGKIKET GQIITAMKVI AMHHPKLTVK VTGSPRVSEE
     MYVSVEFTNP FKFSLENVDL RVEGPGVLPF KYKQYSVIAP GTSITWTEAF SPRRAGSTKV
     FAKLDCAALR QVYGETELTV QE
//
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