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Database: UniProt
Entry: F1R2G3_DANRE
LinkDB: F1R2G3_DANRE
Original site: F1R2G3_DANRE 
ID   F1R2G3_DANRE            Unreviewed;       796 AA.
AC   F1R2G3; F1R1C4;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   20-JUN-2018, entry version 55.
DE   SubName: Full=Transient receptor potential cation channel subfamily c member 1 {ECO:0000313|EMBL:AGW27444.1};
DE   SubName: Full=Transient receptor potential cation channel, subfamily C, member 1 {ECO:0000313|Ensembl:ENSDARP00000116329};
GN   Name=trpc1 {ECO:0000313|EMBL:AGW27444.1,
GN   ECO:0000313|Ensembl:ENSDARP00000116329,
GN   ECO:0000313|ZFIN:ZDB-GENE-070830-1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000116329, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000116329}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000116329};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:AGW27444.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Wik {ECO:0000313|EMBL:AGW27444.1};
RX   PubMed=24038627; DOI=10.1002/dvdy.24041;
RA   Von Niederhausern V., Kastenhuber E., Stauble A., Gesemann M.,
RA   Neuhauss S.C.;
RT   "Phylogeny and expression of canonical transient receptor potential
RT   (TRPC) genes in developing zebrafish.";
RL   Dev. Dyn. 242:1427-1441(2013).
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000116329, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000116329,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS01006510}.
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DR   EMBL; BX470196; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF446627; AGW27444.1; -; mRNA.
DR   UniGene; Dr.103471; -.
DR   STRING; 7955.ENSDARP00000116329; -.
DR   Ensembl; ENSDART00000087034; ENSDARP00000081468; ENSDARG00000061203.
DR   Ensembl; ENSDART00000139191; ENSDARP00000116329; ENSDARG00000061203.
DR   ZFIN; ZDB-GENE-070830-1; trpc1.
DR   eggNOG; KOG3609; Eukaryota.
DR   eggNOG; ENOG410XQ0Y; LUCA.
DR   GeneTree; ENSGT00760000119180; -.
DR   OMA; PKTICYL; -.
DR   OrthoDB; EOG091G029I; -.
DR   TreeFam; TF313147; -.
DR   Reactome; R-DRE-3295583; TRP channels.
DR   Reactome; R-DRE-5578775; Ion homeostasis.
DR   Reactome; R-DRE-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
DR   Proteomes; UP000000437; Chromosome 24.
DR   Bgee; ENSDARG00000061203; -.
DR   ExpressionAtlas; F1R1C4; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR   GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0001525; P:angiogenesis; IMP:ZFIN.
DR   GO; GO:0046847; P:filopodium assembly; IMP:ZFIN.
DR   GO; GO:0006828; P:manganese ion transport; IBA:GO_Central.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   GO; GO:0001570; P:vasculogenesis; IMP:ZFIN.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR005457; TRPC1_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 1.
DR   PANTHER; PTHR10117:SF56; PTHR10117:SF56; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   PRINTS; PR01642; TRPCHANNEL1.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat {ECO:0000256|SAAS:SAAS00933366};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Ion channel {ECO:0000256|SAAS:SAAS00790162};
KW   Ion transport {ECO:0000256|SAAS:SAAS00790154};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:AGW27444.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00788392}.
FT   TRANSMEM    349    369       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    381    402       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    414    433       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    453    472       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    493    516       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    536    558       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    590    611       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    623    645       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      191    253       TRP_2. {ECO:0000259|Pfam:PF08344}.
FT   DOMAIN      392    659       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   796 AA;  91997 MW;  BB9A726FE5E43BE0 CRC64;
     MHISALPYSL SVIMAALYQG TDSSSPDKYL ALKDVREVKE ETTLDEKLFL LACEKGDYYM
     VKKLLEEKRH GELNINCVDV LGRDAVTISI ENENLDILQL LLDHGCQATD ALLVAIDSEV
     VGAVDILLNH RPRRSSKPSI AKLIQKIQNP EYSTTMDVAP VILAAHRNNY EILTMLLKQD
     ISLPRPHAVG CECTLCNAKN KKDSLRHSRF RLDIYRCLAS PSLIMLTEED PILRAFELSA
     DLKELSLVEV EFRNDYEELA KQCKMFAKDL LAQARNSREL EVILNHTSSE DHVDKRGLLE
     ERMNLSRLKL AIKYNQKEFV AQSNCQQFLN TVWFGEMASY RRKHTCLKIV SVLSVALLWP
     LLSICYLLGP RSRVGQVIHT PFIKFIIHSA SYFTFLLLLN LYSLIYNDKK NMAPALQFID
     YLLILWIIGM VWSDVKRLWY EGLEDFLEES RNQLSFVMNS LYLATFALKI VAHNKYSKII
     KPEERKEWDA FHPTLVAEGL FAFAIVLSYL RLFFMYTTSS ILGPLQISMG QMLQEFGKFL
     GLFLLVLISF TIGLTQLYGK DQDPSKTKDD NKDCEGIYCQ QQSNDTFHTF MGTCYALFWY
     IFSLAHVNLF VTRISYTEEL RSFVGALIVG TYNIVVVIVL TKLLVAMLHK SFRQIANHED
     KEWKFARAKL WLSYFDDKCT LPPPFNVLPS PKTVCYLVIS MSKWICSHTS TGKVKRQNSL
     REWTNLKQKR DQNYQKIMCC LVHRYLTSTR QKMQSMDQAT VENLNDLRQD LSKFRNEMRD
     LLGFRTSKYA MFYPRS
//
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