ID F1R2S9_DANRE Unreviewed; 731 AA.
AC F1R2S9; A0A8N7UV16;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Extracellular matrix protein 2 {ECO:0000313|Ensembl:ENSDARP00000116963, ECO:0000313|RefSeq:XP_686507.3};
GN Name=ecm2 {ECO:0000313|Ensembl:ENSDARP00000116963,
GN ECO:0000313|RefSeq:XP_686507.3, ECO:0000313|ZFIN:ZDB-GENE-050208-651};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000116963};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000116963}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000116963};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000116963, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000116963};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_686507.3}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_686507.3};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX465868; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_686507.3; XM_681415.6.
DR STRING; 7955.ENSDARP00000116963; -.
DR PaxDb; 7955-ENSDARP00000116963; -.
DR Ensembl; ENSDART00000136961; ENSDARP00000116963; ENSDARG00000071549.
DR Ensembl; ENSDART00000136961.3; ENSDARP00000116963.2; ENSDARG00000071549.7.
DR GeneID; 558224; -.
DR KEGG; dre:558224; -.
DR AGR; ZFIN:ZDB-GENE-050208-651; -.
DR CTD; 1842; -.
DR ZFIN; ZDB-GENE-050208-651; ecm2.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_000288_186_2_1; -.
DR OMA; MTMYNRA; -.
DR OrthoDB; 5361311at2759; -.
DR PhylomeDB; F1R2S9; -.
DR TreeFam; TF330031; -.
DR Proteomes; UP000000437; Chromosome 22.
DR Bgee; ENSDARG00000071549; Expressed in swim bladder and 15 other cell types or tissues.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0070052; F:collagen V binding; IBA:GO_Central.
DR GO; GO:0008201; F:heparin binding; IBA:GO_Central.
DR GO; GO:0030198; P:extracellular matrix organization; IBA:GO_Central.
DR GO; GO:0010811; P:positive regulation of cell-substrate adhesion; IBA:GO_Central.
DR Gene3D; 6.20.200.20; -; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR043184; ECM2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR46544:SF1; EXTRACELLULAR MATRIX PROTEIN 2; 1.
DR PANTHER; PTHR46544; EXTRACELLULAR MATRIX PROTEIN 2-RELATED; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF00093; VWC; 1.
DR SMART; SM00364; LRR_BAC; 3.
DR SMART; SM00369; LRR_TYP; 10.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..731
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041116786"
FT DOMAIN 87..144
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REGION 28..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 731 AA; 83285 MW; 38E2421DF19D4AAD CRC64;
MRPNLILAMS LLACLTFSLA NEQRRPLVQG KRRGVGPKRA RKQTSNISLQ QGRTPESNGQ
DRSVFMESYK KTKEPKPNFE VTAGKSENCV FRGITMYDQT AWSPKPCVSC LCSKGEVVCD
QILCPTLQCQ LKFQPMGECC PICIDQVLDE FSGDPPTPND LADPYIEISH NRRDKDRLKK
DEEERVRKKD AERKQRKKQK KEEAERQKKL KEAKEAKEKE AEQRRLREEE EEKAAAEERK
KKMEEQRRAE EERARRLEME QREMMRALEE AAERAQEGLR GDEATEDEDI VWLRGDVFQM
SLVQPTKEAS PSLLPLPEPS EPVEEDTETG EEGPDVFEEE SEMVTTLLPP GCTISDVIVT
CENAKLMGIP PLSIPELKSL NLQGNEIKTI PAGAFNGIPN LEWIDLGKNK IHSSGIDPQA
FKGLKLLSRL YMDGNLLEQI PTELPSTLQE LKINENNLRE IEENSFEGLS SLVTLEMEGN
LLSEGNVNPQ AFKPLKELNY LRLNRNHFRT IPQGLPESLL ELYLENNLIE DISEMAFNHT
TNINVVVLRH NKLDESGIAP LAWINNRNLE SIDLSYNNFY LVPSFLPKSL VHLVLVGNQI
ERIPGYVFAH MEPGLEYLYL SYNKLDGDGV EPESFFGTLN TMTELCLDHN HLMAIPMGIN
EMTTLHFLRL NNNKIRHVPE QAICDPLSED DSHLVAVRLE NNFIDPRKIP PTAFSCVRSY
SSVVLKPQRI K
//
