ID F1R5N4_DANRE Unreviewed; 737 AA.
AC F1R5N4; A0A8M1NFK9;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 82.
DE SubName: Full=Ligand of Numb protein X 2 {ECO:0000313|RefSeq:NP_001106696.2};
DE SubName: Full=Ligand of numb-protein X 2a {ECO:0000313|Ensembl:ENSDARP00000046210};
GN Name=lnx2 {ECO:0000313|RefSeq:NP_001106696.2};
GN OrderedLocusNames=lnx2a {ECO:0000313|Ensembl:ENSDARP00000046210,
GN ECO:0000313|RefSeq:NP_001106696.2,
GN ECO:0000313|ZFIN:ZDB-GENE-060228-2};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000046210};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000046210}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000046210};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000046210, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000046210};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:NP_001106696.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26392552;
RA Won M., Ro H., Dawid I.B.;
RT "Lnx2 ubiquitin ligase is essential for exocrine cell differentiation in
RT the early zebrafish pancreas.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:12426-12431(2015).
RN [4] {ECO:0000313|RefSeq:NP_001106696.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [5] {ECO:0000313|RefSeq:NP_001106696.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28362803;
RA Won M., Dawid I.B.;
RT "PCR artifact in testing for homologous recombination in genomic editing in
RT zebrafish.";
RL PLoS ONE 12:e0172802-e0172802(2017).
RN [6] {ECO:0000313|RefSeq:NP_001106696.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; BX571696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR392367; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001106696.2; NM_001113225.2.
DR STRING; 7955.ENSDARP00000046210; -.
DR PaxDb; 7955-ENSDARP00000046210; -.
DR Ensembl; ENSDART00000046211.8; ENSDARP00000046210.5; ENSDARG00000029177.9.
DR Ensembl; ENSDART00000191334.1; ENSDARP00000147564.1; ENSDARG00000112805.1.
DR GeneID; 553331; -.
DR KEGG; dre:553331; -.
DR CTD; 553331; -.
DR ZFIN; ZDB-GENE-060228-2; lnx2a.
DR eggNOG; KOG3528; Eukaryota.
DR OMA; MNINGID; -.
DR OrthoDB; 3028121at2759; -.
DR TreeFam; TF330709; -.
DR Proteomes; UP000000437; Alternate scaffold 24.
DR Proteomes; UP000000437; Chromosome 24.
DR Bgee; ENSDARG00000029177; Expressed in brain and 18 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IDA:ZFIN.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
DR GO; GO:0031017; P:exocrine pancreas development; IMP:ZFIN.
DR CDD; cd16780; mRING-HC-C3HC3D_LNX2; 1.
DR CDD; cd00992; PDZ_signaling; 4.
DR Gene3D; 2.30.42.10; -; 4.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR19964:SF33; LIGAND OF NUMB PROTEIN X 2; 1.
DR PANTHER; PTHR19964; MULTIPLE PDZ DOMAIN PROTEIN; 1.
DR Pfam; PF00595; PDZ; 4.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00228; PDZ; 4.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 4.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50106; PDZ; 4.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 49..87
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 270..355
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 376..459
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 517..603
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 647..733
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 137..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 737 AA; 80495 MW; 1003DA245F37D050 CRC64;
MGSLGEGVDP GMVSEALLEA LCSECGQIHR TWENHLYNYR LEVDDDLVCH ICLQPLVQPL
DTPCGHTFCA RCLRSFLQER DFCPLDRAHL QLQVCRRSSI LVHKLLDKLS VTCPLTPSCS
LSMPRCDLEA HLKHRCPGTQ SQRTKLERTQ MEGSEDRVTA TNPPKSPQTE IKEDTPSPPA
GSNACNNVPT WTEEPGIDNP AFEESTEEDS VHGLECALPR VKRPLSNPCI HLLRTGSSAS
SGWDFVETLP LSAEEGCVKL PSLPEGEITT IEVHRTNPYS EMGISIVGGN ETPLINVVIQ
EVYRDGVIAR DGRLLAGDQI LQVNNVDISN VPHNFARSTL ARPCATLQLT VLRERRCSAR
PPAATASPKG SPASIRITLH KRESSEQLGI KLVRRTDEAG VFILDLLEGG LAAKDGRLCS
NDRVLAVNEH DLRHGTPELA AQIIQASGER VNLLISRSSK QTMAVHTGST LTRDIWSHDH
IPPLPSTATP SPVPSLHLAR SSTQRDLSQC VNCKEKHITV KKEPHESLGM TVAGGRGSKS
GELPIFVTSV QPHGCLSRDG RIKRGDVLLS INGQDLTYLS HSEAVGTLKS SATSCSVQLK
ALEVTMVEEP GLDEELLPPH ENDYDASWSP SWVLWLGLPS YLHSSHEIVL RRSHPGSWGF
SIVGGYEENH SNQAFFIKTI VLGTPAYYDG RLKCGDMIVA VNGLSTAGMS HSALVPMLKE
QRSRVALTVV SWPGSLI
//