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Database: UniProt
Entry: F1R5N4_DANRE
LinkDB: F1R5N4_DANRE
Original site: F1R5N4_DANRE 
ID   F1R5N4_DANRE            Unreviewed;       737 AA.
AC   F1R5N4; A0A8M1NFK9;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   24-JAN-2024, entry version 82.
DE   SubName: Full=Ligand of Numb protein X 2 {ECO:0000313|RefSeq:NP_001106696.2};
DE   SubName: Full=Ligand of numb-protein X 2a {ECO:0000313|Ensembl:ENSDARP00000046210};
GN   Name=lnx2 {ECO:0000313|RefSeq:NP_001106696.2};
GN   OrderedLocusNames=lnx2a {ECO:0000313|Ensembl:ENSDARP00000046210,
GN   ECO:0000313|RefSeq:NP_001106696.2,
GN   ECO:0000313|ZFIN:ZDB-GENE-060228-2};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000046210};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000046210}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000046210};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000046210, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000046210};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RG   Genome Reference Consortium Zebrafish;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA   Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA   Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA   Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA   Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA   Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA   Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA   Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA   Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA   Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA   Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA   Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA   Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA   Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA   Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA   Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA   Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA   Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA   Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA   Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA   Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA   Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [3] {ECO:0000313|RefSeq:NP_001106696.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26392552;
RA   Won M., Ro H., Dawid I.B.;
RT   "Lnx2 ubiquitin ligase is essential for exocrine cell differentiation in
RT   the early zebrafish pancreas.";
RL   Proc. Natl. Acad. Sci. U.S.A. 112:12426-12431(2015).
RN   [4] {ECO:0000313|RefSeq:NP_001106696.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=27189481;
RA   Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA   Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA   Bobe J.;
RT   "Gene evolution and gene expression after whole genome duplication in fish:
RT   the PhyloFish database.";
RL   BMC Genomics 17:368-368(2016).
RN   [5] {ECO:0000313|RefSeq:NP_001106696.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=28362803;
RA   Won M., Dawid I.B.;
RT   "PCR artifact in testing for homologous recombination in genomic editing in
RT   zebrafish.";
RL   PLoS ONE 12:e0172802-e0172802(2017).
RN   [6] {ECO:0000313|RefSeq:NP_001106696.2}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   EMBL; BX571696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR392367; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001106696.2; NM_001113225.2.
DR   STRING; 7955.ENSDARP00000046210; -.
DR   PaxDb; 7955-ENSDARP00000046210; -.
DR   Ensembl; ENSDART00000046211.8; ENSDARP00000046210.5; ENSDARG00000029177.9.
DR   Ensembl; ENSDART00000191334.1; ENSDARP00000147564.1; ENSDARG00000112805.1.
DR   GeneID; 553331; -.
DR   KEGG; dre:553331; -.
DR   CTD; 553331; -.
DR   ZFIN; ZDB-GENE-060228-2; lnx2a.
DR   eggNOG; KOG3528; Eukaryota.
DR   OMA; MNINGID; -.
DR   OrthoDB; 3028121at2759; -.
DR   TreeFam; TF330709; -.
DR   Proteomes; UP000000437; Alternate scaffold 24.
DR   Proteomes; UP000000437; Chromosome 24.
DR   Bgee; ENSDARG00000029177; Expressed in brain and 18 other cell types or tissues.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IDA:ZFIN.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
DR   GO; GO:0031017; P:exocrine pancreas development; IMP:ZFIN.
DR   CDD; cd16780; mRING-HC-C3HC3D_LNX2; 1.
DR   CDD; cd00992; PDZ_signaling; 4.
DR   Gene3D; 2.30.42.10; -; 4.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR018957; Znf_C3HC4_RING-type.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR19964:SF33; LIGAND OF NUMB PROTEIN X 2; 1.
DR   PANTHER; PTHR19964; MULTIPLE PDZ DOMAIN PROTEIN; 1.
DR   Pfam; PF00595; PDZ; 4.
DR   Pfam; PF00097; zf-C3HC4; 1.
DR   SMART; SM00228; PDZ; 4.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 4.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50106; PDZ; 4.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   DOMAIN          49..87
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   DOMAIN          270..355
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          376..459
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          517..603
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          647..733
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   REGION          137..207
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        155..193
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   737 AA;  80495 MW;  1003DA245F37D050 CRC64;
     MGSLGEGVDP GMVSEALLEA LCSECGQIHR TWENHLYNYR LEVDDDLVCH ICLQPLVQPL
     DTPCGHTFCA RCLRSFLQER DFCPLDRAHL QLQVCRRSSI LVHKLLDKLS VTCPLTPSCS
     LSMPRCDLEA HLKHRCPGTQ SQRTKLERTQ MEGSEDRVTA TNPPKSPQTE IKEDTPSPPA
     GSNACNNVPT WTEEPGIDNP AFEESTEEDS VHGLECALPR VKRPLSNPCI HLLRTGSSAS
     SGWDFVETLP LSAEEGCVKL PSLPEGEITT IEVHRTNPYS EMGISIVGGN ETPLINVVIQ
     EVYRDGVIAR DGRLLAGDQI LQVNNVDISN VPHNFARSTL ARPCATLQLT VLRERRCSAR
     PPAATASPKG SPASIRITLH KRESSEQLGI KLVRRTDEAG VFILDLLEGG LAAKDGRLCS
     NDRVLAVNEH DLRHGTPELA AQIIQASGER VNLLISRSSK QTMAVHTGST LTRDIWSHDH
     IPPLPSTATP SPVPSLHLAR SSTQRDLSQC VNCKEKHITV KKEPHESLGM TVAGGRGSKS
     GELPIFVTSV QPHGCLSRDG RIKRGDVLLS INGQDLTYLS HSEAVGTLKS SATSCSVQLK
     ALEVTMVEEP GLDEELLPPH ENDYDASWSP SWVLWLGLPS YLHSSHEIVL RRSHPGSWGF
     SIVGGYEENH SNQAFFIKTI VLGTPAYYDG RLKCGDMIVA VNGLSTAGMS HSALVPMLKE
     QRSRVALTVV SWPGSLI
//
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