ID F1R647_DANRE Unreviewed; 227 AA.
AC F1R647; A0A8M1P1U5;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=EF-hand domain family, member D1 {ECO:0000313|Ensembl:ENSDARP00000063778};
DE SubName: Full=EF-hand domain-containing protein D1 {ECO:0000313|RefSeq:NP_001292523.1};
GN Name=efhd1 {ECO:0000313|Ensembl:ENSDARP00000063778,
GN ECO:0000313|RefSeq:NP_001292523.1,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-7461};
GN Synonyms=fj19b07 {ECO:0000313|RefSeq:NP_001292523.1},
GN si:ch211-281l24.1 {ECO:0000313|RefSeq:NP_001292523.1}, wu:fj19b07
GN {ECO:0000313|RefSeq:NP_001292523.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000063778};
RN [1] {ECO:0000313|RefSeq:NP_001292523.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17849447;
RA Kiefer J.C.;
RT "Is your 'gene of interest' interesting?";
RL Dev. Dyn. 236:2962-2969(2007).
RN [2] {ECO:0000313|RefSeq:NP_001292523.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21244694;
RA Dutting S., Brachs S., Mielenz D.;
RT "Fraternal twins: Swiprosin-1/EFhd2 and Swiprosin-2/EFhd1, two homologous
RT EF-hand containing calcium binding adaptor proteins with distinct
RT functions.";
RL Cell Commun. Signal. 9:2-2(2011).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000063778}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000063778};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [4] {ECO:0000313|Ensembl:ENSDARP00000063778, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000063778};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|RefSeq:NP_001292523.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [6] {ECO:0000313|RefSeq:NP_001292523.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [7] {ECO:0000313|RefSeq:NP_001292523.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [8] {ECO:0000313|RefSeq:NP_001292523.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CR388129; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001292523.1; NM_001305594.1.
DR STRING; 7955.ENSDARP00000063778; -.
DR PaxDb; 7955-ENSDARP00000063778; -.
DR Ensembl; ENSDART00000063779; ENSDARP00000063778; ENSDARG00000043446.
DR Ensembl; ENSDART00000063779.4; ENSDARP00000063778.3; ENSDARG00000043446.4.
DR GeneID; 335521; -.
DR KEGG; dre:335521; -.
DR AGR; ZFIN:ZDB-GENE-030131-7461; -.
DR CTD; 80303; -.
DR ZFIN; ZDB-GENE-030131-7461; efhd1.
DR eggNOG; KOG0041; Eukaryota.
DR HOGENOM; CLU_094429_0_0_1; -.
DR OMA; MFAERQN; -.
DR OrthoDB; 2332111at2759; -.
DR PhylomeDB; F1R647; -.
DR TreeFam; TF320736; -.
DR Reactome; R-DRE-9013405; RHOD GTPase cycle.
DR Proteomes; UP000000437; Chromosome 15.
DR Bgee; ENSDARG00000043446; Expressed in early embryo and 22 other cell types or tissues.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR049025; AIF-1_EF_pair.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR040365; EFHD1/2.
DR PANTHER; PTHR13025; EF-HAND DOMAIN-CONTAINING PROTEIN D; 1.
DR PANTHER; PTHR13025:SF8; EF-HAND DOMAIN-CONTAINING PROTEIN D1; 1.
DR Pfam; PF21008; AIF-1; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 78..113
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 114..149
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 183..224
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 227 AA; 26249 MW; E4415DB09A34E5C2 CRC64;
MSSEELARKL QRRLDADTNP GTQDEETPVK PATTMSDDTT SELTEKLNRR LDIHDGTAKP
KQMKVFNPYT EFKEFSRKQI KDMETMFKRF DSGKDGFIDL MELKLMMEKL GAPQTHLGLK
NMIKEVDEDY DGKLSYREFL LIFRRAAAGE LQEESGLMAL ARLSEIDVST EGVLGARDFF
EAKAQALSVR SKFEAELREE QEERKRLELE RKQRRAAFKE LQSTFCS
//
