ID F1RAG3_DANRE Unreviewed; 1175 AA.
AC F1RAG3; A0A8N7UUY5;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=Nidogen 1a {ECO:0000313|Ensembl:ENSDARP00000090249};
DE SubName: Full=Nidogen-1 isoform X1 {ECO:0000313|RefSeq:XP_691156.5};
GN Name=nid1a {ECO:0000313|Ensembl:ENSDARP00000090249,
GN ECO:0000313|RefSeq:XP_691156.5, ECO:0000313|ZFIN:ZDB-GENE-050302-58};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000090249};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000090249}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000090249};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000090249, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000090249};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_691156.5}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_691156.5};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AL928828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU367849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU651583; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_691156.5; XM_686064.8.
DR STRING; 7955.ENSDARP00000090249; -.
DR Ensembl; ENSDART00000099475; ENSDARP00000090249; ENSDARG00000068710.
DR Ensembl; ENSDART00000099475.6; ENSDARP00000090249.4; ENSDARG00000068710.7.
DR GeneID; 562690; -.
DR AGR; ZFIN:ZDB-GENE-050302-58; -.
DR CTD; 562690; -.
DR ZFIN; ZDB-GENE-050302-58; nid1a.
DR eggNOG; KOG1214; Eukaryota.
DR HOGENOM; CLU_003163_1_0_1; -.
DR OMA; PGTGNQF; -.
DR OrthoDB; 25347at2759; -.
DR TreeFam; TF320666; -.
DR Reactome; R-DRE-1474228; Degradation of the extracellular matrix.
DR Reactome; R-DRE-3000157; Laminin interactions.
DR Proteomes; UP000000437; Chromosome 13.
DR Bgee; ENSDARG00000068710; Expressed in pharyngeal gill and 26 other cell types or tissues.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0042813; F:Wnt receptor activity; IBA:GO_Central.
DR GO; GO:0017147; F:Wnt-protein binding; IBA:GO_Central.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00255; nidG2; 1.
DR CDD; cd00191; TY; 1.
DR Gene3D; 2.40.155.10; Green fluorescent protein; 1.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR006605; G2_nidogen/fibulin_G2F.
DR InterPro; IPR009017; GFP.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR003886; NIDO_dom.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR46513:SF6; NIDOGEN-1; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF12947; EGF_3; 2.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF07474; G2F; 1.
DR Pfam; PF00058; Ldl_recept_b; 3.
DR Pfam; PF06119; NIDO; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00682; G2F; 1.
DR SMART; SM00135; LY; 4.
DR SMART; SM00539; NIDO; 1.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF54511; GFP-like; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS51120; LDLRB; 3.
DR PROSITE; PS51220; NIDO; 1.
DR PROSITE; PS50993; NIDOGEN_G2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 1: Evidence at protein level;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00500};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022869};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1RAG3};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022869}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1175
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041116794"
FT DOMAIN 99..252
FT /note="NIDO"
FT /evidence="ECO:0000259|PROSITE:PS51220"
FT DOMAIN 374..603
FT /note="Nidogen G2 beta-barrel"
FT /evidence="ECO:0000259|PROSITE:PS50993"
FT DOMAIN 602..643
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 644..686
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 691..734
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 735..773
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 778..848
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT REPEAT 918..960
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 961..1003
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1004..1048
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 818..825
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ SEQUENCE 1175 AA; 130100 MW; 5AF20E955A1CAF88 CRC64;
MGRHGHRHPF WVILFGLTLS VSGITRHELF PFGRNAGDQS LREGNDETQE VNLDKPITFH
DEQFSKIYIN TNGFVALEKP TGESEYLENM PASFKMIAAL QGDLDTSDGV GKVFFRQDFS
TALLQQAADH INRAFPEDDL VNPIHALVVT WLDVASHKAE SRGDGLEHSI RRNTFQLVIA
SVETSSYAIL LYPRDSIQFQ STGSGYTVHA GFSKTQELYY RNTEDTEASV KDLPEQTNSG
KRGVWVYEIG TFPHFTNIAP GEVPDLPLDS LRRSETQNQQ QQVYPDVQQE NLDGVYHHPE
HPPPIQVHTV QFTPQDPQVV EIENDDNIQV DVFTYNSGQC GGQKCSKFAE CSGRCCVCKP
GYYGSGVHCV PEGVPQRMNG KVSGRVFVGN SPVPVDFASN DLHSYVVAND GRAYVAISAI
PPVIGFSLQP LSSVGGVIGW AFALQQPGFK NGFSIIGGEF KRQADVSFQP GGEKLTISQE
FRGIDEHDHL MVDTRLEGKI PEVPQGATVQ IDSYSEIYQY SINLITSSST REYVISLPDG
STQSRSYNFR ETITFQGCQF DEVPSTQMLS VEQVFVMYDM GAQLLRYAMS NKIGDVNGGQ
SEENACFTGR HGCDTNAVCK PGQGNQFTCE CAAGFTGDGR ACYDIDECRE TPQICGQNSI
CNNQPGTFRC ECLDGFQFAS DGQTCVEVHR PVDPCRSGTH DCDVPERARC SYTGGSSYIC
TCAPGFMGDG RRCQDIDECQ VNQCHENAVC FNTPGSFSCQ CNPGFHGDGF YCSTEREKTR
CELHKESVVG FGPHSARPQP GRFVPTCDAQ GRYEPMQCHA SIGQCWCVDR DGEEISGTRT
GPGRFPVCRG HDESGPIRPT PNPNISPLPP GSHILFTQSG KIEYIPLDGH NLKKNEAKTA
LHLPEKVVIG IAYDCVEKMI YWTDISTPAI SRANLQGGEP VQLIKSDIGS PEGIAIDHLG
RNMFWTDSMK DRIEVSSLDG TQRRVLVNTD LVNPRAILTD STNGYIYWAD WNRESPKIEM
AYMDGTNRRV LAKDDLSLPN GLTYDPQTSL LCWADAGTHK VECMNPQQGR RTQLMEEIQY
PFGLTTDGKN FYYTDWTRVS VVVVDRHLRR EVDEFQPQKR TRLYGITTAH ARCPAGQNYC
SSNNGGCTHL CLATPAGRSC RCPDNAAELG CVERE
//
