ID F1RC25_DANRE Unreviewed; 1222 AA.
AC F1RC25; A0A8N7XJG7; S5UFQ3;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Transient receptor potential cation channel, subfamily M, member 4b, transient receptor potential cation channel, subfamily M, member 4b, tandem duplicate 2 {ECO:0000313|Ensembl:ENSDARP00000087119, ECO:0000313|RefSeq:NP_001269082.1};
DE SubName: Full=Transient receptor potential melastatin 4b1 {ECO:0000313|EMBL:AGS55984.1};
GN Name=trpm4b.2 {ECO:0000313|Ensembl:ENSDARP00000087119,
GN ECO:0000313|RefSeq:NP_001269082.1,
GN ECO:0000313|ZFIN:ZDB-GENE-061214-2};
GN Synonyms=TRPM4b1 {ECO:0000313|EMBL:AGS55984.1}, trpm4c
GN {ECO:0000313|RefSeq:NP_001269082.1,
GN ECO:0000313|ZFIN:ZDB-GENE-061214-2};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AGS55984.1};
RN [1] {ECO:0000313|RefSeq:NP_001269082.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WIK {ECO:0000313|RefSeq:NP_001269082.1};
RX PubMed=16926268;
RA Saito S., Shingai R.;
RT "Evolution of thermoTRP ion channel homologs in vertebrates.";
RL Physiol. Genomics 27:219-230(2006).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000087119}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000087119};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [3] {ECO:0000313|EMBL:AGS55984.1, ECO:0000313|RefSeq:NP_001269082.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WIK {ECO:0000313|RefSeq:NP_001269082.1}, and Wik
RC {ECO:0000313|EMBL:AGS55984.1};
RX PubMed=23908157; DOI=10.1002/dvdy.24020;
RA Kastenhuber E., Gesemann M., Mickoleit M., Neuhauss S.C.;
RT "Phylogenetic analysis and expression of zebrafish transient receptor
RT potential melastatin family genes.";
RL Dev. Dyn. 242:1236-1249(2013).
RN [4] {ECO:0000313|Ensembl:ENSDARP00000087119, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000087119};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|RefSeq:NP_001269082.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WIK {ECO:0000313|RefSeq:NP_001269082.1};
RX PubMed=26432160;
RA Cheng H., Ellis J., Kleinow K.M.;
RT "Expression and functionality of transient receptor potential melastatin 4
RT (TRPM4)-like channels during development of the zebrafish.";
RL Comp. Biochem. Physiol. C Toxicol. Pharmacol. 178:33-44(2015).
RN [6] {ECO:0000313|RefSeq:NP_001269082.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WIK {ECO:0000313|RefSeq:NP_001269082.1};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [7] {ECO:0000313|RefSeq:NP_001269082.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WIK {ECO:0000313|RefSeq:NP_001269082.1};
RX PubMed=27494266;
RA Han B., Li W., Chen Z., Xu Q., Luo J., Shi Y., Li X., Yan X., Zhang J.;
RT "Variation of DNA Methylome of Zebrafish Cells under Cold Pressure.";
RL PLoS ONE 11:e0160358-e0160358(2016).
RN [8] {ECO:0000313|RefSeq:NP_001269082.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WIK {ECO:0000313|RefSeq:NP_001269082.1};
RX PubMed=28689714;
RA Jeronimo R., Moraes M.N., de Assis L.V.M., Ramos B.C., Rocha T.,
RA Castrucci A.M.L.;
RT "Thermal stress in Danio rerio: a link between temperature, light, thermo-
RT TRP channels, and clock genes.";
RL J. Therm. Biol. 68:128-138(2017).
RN [9] {ECO:0000313|RefSeq:NP_001269082.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WIK {ECO:0000313|RefSeq:NP_001269082.1};
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [10] {ECO:0000313|RefSeq:NP_001269082.1}
RP IDENTIFICATION.
RC STRAIN=WIK {ECO:0000313|RefSeq:NP_001269082.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CABZ01030103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01030104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01030105; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01030106; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF305310; AGS55984.1; -; mRNA.
DR RefSeq; NP_001269082.1; NM_001282153.1.
DR STRING; 7955.ENSDARP00000087119; -.
DR PaxDb; 7955-ENSDARP00000087119; -.
DR Ensembl; ENSDART00000092687; ENSDARP00000087119; ENSDARG00000063435.
DR Ensembl; ENSDART00000092687.6; ENSDARP00000087119.5; ENSDARG00000063435.6.
DR GeneID; 799647; -.
DR KEGG; dre:799647; -.
DR AGR; ZFIN:ZDB-GENE-061214-2; -.
DR CTD; 799647; -.
DR ZFIN; ZDB-GENE-061214-2; trpm4b.2.
DR eggNOG; KOG3614; Eukaryota.
DR OMA; EKIHQFA; -.
DR OrthoDB; 201873at2759; -.
DR TreeFam; TF314204; -.
DR Proteomes; UP000000437; Chromosome 12.
DR Bgee; ENSDARG00000063435; Expressed in zone of skin and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IBA:GO_Central.
DR GO; GO:0099604; F:ligand-gated calcium channel activity; IBA:GO_Central.
DR GO; GO:0070588; P:calcium ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR PANTHER; PTHR13800:SF6; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 4; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR SUPFAM; SSF140860; Pseudo ankyrin repeat-like; 1.
PE 2: Evidence at transcript level;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:AGS55984.1, ECO:0000313|RefSeq:NP_001269082.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 797..820
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 880..898
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 904..924
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 944..968
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1027..1052
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 98..366
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 811..1063
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
SQ SEQUENCE 1222 AA; 139468 MW; 48F8BEDF9756D60A CRC64;
MNEKDIEEGG VAVMPKDLSW IPTFFKKRLC TTFVEDSFSN GGLCQCGAAR DHHPSVALGD
NFSTAVVSQW FSTQHSSEQP TDAYGELDFN NSRKRDSYFL RLSSTTDPAK VFDLMKEHWK
LQQPNLVVSV VGGEGRSEVK SWVLDILRQG LVKTAQSTGA WIITGGLRQG ISRCIGEAVK
DNATAVSSIT LNKVLPIGIA PWGLVENRQH LVNSEGSFPA KVTTQDSCNL DNNHKAFLLV
DDGTTGRKGG ELAFRARLED YISRQRPGNA SIDIPVLNML IAGDTSMLEF LEMSLKNSTP
CLVLAGSGGL ANLVSDIVEN VQSAAMPGAS EKEDASPIME LREQLAAKVK KYFPAEKKTD
KLVDKVLSIY QNKDIISIYN AEQEGAEDFD IVMLKVLVQA SKRNVSENTN SYADELRLAV
TWNRVDIAKS ELFNGHIDWK YEELKDSMTD ALENNKPQFV RLLIDNGLNI STYLTYNRLE
ILYNSISDTC LAKTLLLHHL NERIHQSIKQ IYKISLYEVS QLLTDLFGEV CLPFYKAELK
LEATTKRKAL KNACDVLNGS CTYRDEKCKH PWLCLFIWAV LQNRREMAIF FWEMCGESVL
TALAGCKLLL ELSKQEIETE AKLSMKELAL KFEQMAHDVF GTCYQTKASH SYKLLIRKSK
LWGDATCLKM AIAADARIFF SHDGVQSLLS QIWWGDIERG TAFWRLLLVM ICPPLCYTNC
IEFRKTDPAK EEKSMTAPPS SPTDSHYEKT VYSFKDIKHQ NEGENEDSNH IRQNTKGEPA
FIESMKSSFV VSRWKQFWYA PVTSFIGNLL MYFLFLFLYA YVLLVDFKPP PPDGPAVSEY
VLYFWVFTLV CEEIREASIA GNKKFPQMLF VYAQDMWNKF DVLAISLFIT GLCCRMFSWS
FNMGRGILCV DYMVFTLRLI HIFAIHRQLG PKIIILGKMI KDAFFFLFFL LVWLSAYGVA
NQALLYQYDP SPARTFRRVL YRPYLHIFGQ IPVEEIDTGR HWERDCTDNL TLINEGIEPC
RDTSHNWLVV VLLVIFLLVT NILLVNLLIA TFSYTFSKVQ ERSDTYWKFQ RYNLIVEYHS
RPTLAPPFII LSHINLLIKR KIRKVQSAKV QRFALKIKGQ EKKELVKWEN LQKENYLALE
IKKQRGTDSE RLKRITSKVD SVIKQVAEIR DVDRRLRAVE SEMEFCTSSL QWIMETLSQS
SMVKTTKAHP TRKAVTSASI EK
//
