ID F1REK3_DANRE Unreviewed; 310 AA.
AC F1REK3; A0A8M6Z016;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=tRNA methyltransferase 10 homolog B {ECO:0000256|ARBA:ARBA00035688};
DE EC=2.1.1.221 {ECO:0000256|ARBA:ARBA00012797};
DE AltName: Full=RNA (guanine-9-)-methyltransferase domain-containing protein 3 {ECO:0000256|ARBA:ARBA00035712};
DE AltName: Full=tRNA (guanine(9)-N(1))-methyltransferase TRMT10B {ECO:0000256|ARBA:ARBA00035725};
GN Name=trmt10b {ECO:0000313|Ensembl:ENSDARP00000078938,
GN ECO:0000313|RefSeq:XP_017212404.1,
GN ECO:0000313|ZFIN:ZDB-GENE-061013-313};
GN Synonyms=rg9mtd3 {ECO:0000313|RefSeq:XP_017212404.1}, zgc:153341
GN {ECO:0000313|RefSeq:XP_017212404.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000078938};
RN [1] {ECO:0000313|RefSeq:XP_017212404.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12477932; DOI=10.1073/pnas.242603899;
RG Mammalian Gene Collection Program Team;
RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D.,
RA Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F.,
RA Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., Hopkins R.F., Jordan H.,
RA Moore T., Max S.I., Wang J., Hsieh F., Diatchenko L., Marusina K.,
RA Farmer A.A., Rubin G.M., Hong L., Stapleton M., Soares M.B., Bonaldo M.F.,
RA Casavant T.L., Scheetz T.E., Brownstein M.J., Usdin T.B., Toshiyuki S.,
RA Carninci P., Prange C., Raha S.S., Loquellano N.A., Peters G.J.,
RA Abramson R.D., Mullahy S.J., Bosak S.A., McEwan P.J., McKernan K.J.,
RA Malek J.A., Gunaratne P.H., Richards S., Worley K.C., Hale S., Garcia A.M.,
RA Gay L.J., Hulyk S.W., Villalon D.K., Muzny D.M., Sodergren E.J., Lu X.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., Rodriguez A.C.,
RA Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Krzywinski M.I.,
RA Skalska U., Smailus D.E., Schnerch A., Schein J.E., Jones S.J., Marra M.A.;
RT "Generation and initial analysis of more than 15,000 full-length human and
RT mouse cDNA sequences.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000078938}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000078938};
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSDARP00000078938, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000078938,
RC ECO:0000313|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4] {ECO:0000313|RefSeq:XP_017212404.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=guanosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-
CC methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:43156, Rhea:RHEA-COMP:10367, Rhea:RHEA-COMP:10368,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:73542, ChEBI:CHEBI:74269; EC=2.1.1.221;
CC Evidence={ECO:0000256|ARBA:ARBA00000855};
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DR EMBL; CABZ01030284; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01030285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01030286; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01030287; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017212404.1; XM_017356915.2.
DR Ensembl; ENSDART00000084503.6; ENSDARP00000078938.4; ENSDARG00000060176.7.
DR Ensembl; ENSDART00000173079.2; ENSDARP00000142268.1; ENSDARG00000060176.7.
DR Ensembl; ENSDART00000192779.1; ENSDARP00000154123.1; ENSDARG00000060176.7.
DR GeneID; 768135; -.
DR AGR; ZFIN:ZDB-GENE-061013-313; -.
DR CTD; 158234; -.
DR ZFIN; ZDB-GENE-061013-313; trmt10b.
DR HOGENOM; CLU_034384_8_0_1; -.
DR OMA; ALQAWFP; -.
DR OrthoDB; 2908056at2759; -.
DR TreeFam; TF330972; -.
DR Proteomes; UP000000437; Chromosome 7.
DR Bgee; ENSDARG00000060176; Expressed in mature ovarian follicle and 19 other cell types or tissues.
DR GO; GO:0052905; F:tRNA (guanosine(9)-N1)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd18100; Trm10euk_B; 1.
DR Gene3D; 3.40.1280.30; -; 1.
DR InterPro; IPR028564; MT_TRM10-typ.
DR InterPro; IPR038459; MT_TRM10-typ_sf.
DR InterPro; IPR047911; Trm10_B_MTase_dom.
DR InterPro; IPR007356; tRNA_m1G_MeTrfase_euk.
DR InterPro; IPR016009; tRNA_MeTrfase_TRMD/TRM10.
DR PANTHER; PTHR13563; TRNA (GUANINE-9-) METHYLTRANSFERASE; 1.
DR PANTHER; PTHR13563:SF19; TRNA METHYLTRANSFERASE 10 HOMOLOG B; 1.
DR Pfam; PF01746; tRNA_m1G_MT; 1.
DR PROSITE; PS51675; SAM_MT_TRM10; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|RefSeq:XP_017212404.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 101..298
FT /note="SAM-dependent MTase TRM10-type"
FT /evidence="ECO:0000259|PROSITE:PS51675"
SQ SEQUENCE 310 AA; 35741 MW; 05F36E9FD2260AF3 CRC64;
MEEQLRVGGC SPDGGFTIVN EAPVADLLEF LHIDVELEHA RDDREESARS KNVMRKQRNW
ERRLEVKKSK RKEEKLRKKL NRQDKDVSDA QLSKRVIKAI TKERLEEARA AGLRLCVDLS
MTEHLTHKEI SRLAAQIRRL YGSNKKALQP FHVFLTELQE DSLLYKECVR MNDGFMHYLI
DVTEESWFHL FPSEDVIYLT PDASEALESV EEDKIYILGG LVDETIQKKI SYTKAKELGV
RTARLPIDEY MVKKKNPKNF HSKILAINQV FDILLTFRDT RDWTKALMAG IPPGKGFVLA
SAASKPLEET
//
