GenomeNet

Database: UniProt
Entry: F1REN0_DANRE
LinkDB: F1REN0_DANRE
Original site: F1REN0_DANRE 
ID   F1REN0_DANRE            Unreviewed;       780 AA.
AC   F1REN0; A0A8M1P4A8;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   24-JAN-2024, entry version 76.
DE   RecName: Full=Cullin-5 {ECO:0000256|ARBA:ARBA00040451};
GN   Name=cul5 {ECO:0000313|RefSeq:NP_001314988.1};
GN   Synonyms=wu:fd17d09 {ECO:0000313|RefSeq:NP_001314988.1}, wu:fi20h12
GN   {ECO:0000313|RefSeq:NP_001314988.1}, xx:11fd17d09
GN   {ECO:0000313|RefSeq:NP_001314988.1}, zgc:66185
GN   {ECO:0000313|RefSeq:NP_001314988.1};
GN   OrderedLocusNames=cul5a {ECO:0000313|Ensembl:ENSDARP00000150867,
GN   ECO:0000313|RefSeq:NP_001314988.1,
GN   ECO:0000313|ZFIN:ZDB-GENE-030131-5426};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000100474};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000100474}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000100474};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000100474, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000100474};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RG   Genome Reference Consortium Zebrafish;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA   Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA   Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA   Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA   Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA   Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA   Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA   Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA   Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA   Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA   Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA   Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA   Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA   Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA   Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA   Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA   Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA   Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA   Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA   Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA   Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA   Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [3] {ECO:0000313|RefSeq:NP_001314988.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001314988.1};
RX   PubMed=26469318;
RA   Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA   Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA   Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA   Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA   Reith W., Hertzano R.;
RT   "RFX transcription factors are essential for hearing in mice.";
RL   Nat. Commun. 6:8549-8549(2015).
RN   [4] {ECO:0000313|RefSeq:NP_001314988.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001314988.1};
RX   PubMed=27189481;
RA   Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA   Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA   Bobe J.;
RT   "Gene evolution and gene expression after whole genome duplication in fish:
RT   the PhyloFish database.";
RL   BMC Genomics 17:368-368(2016).
RN   [5] {ECO:0000313|RefSeq:NP_001314988.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001314988.1};
RX   PubMed=28252024;
RA   Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA   Choudhary J.S., Emes R.D., Grant S.G.;
RT   "Evolution of complexity in the zebrafish synapse proteome.";
RL   Nat. Commun. 8:14613-14613(2017).
RN   [6] {ECO:0000313|RefSeq:NP_001314988.1}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001314988.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
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DR   EMBL; BX294000; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX572630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001314988.1; NM_001328059.1.
DR   STRING; 7955.ENSDARP00000100474; -.
DR   PaxDb; 7955-ENSDARP00000100474; -.
DR   Ensembl; ENSDART00000110111.4; ENSDARP00000100474.3; ENSDARG00000069742.6.
DR   Ensembl; ENSDART00000188296.1; ENSDARP00000150867.1; ENSDARG00000112542.1.
DR   Ensembl; ENSDART00000190789.1; ENSDARP00000157577.1; ENSDARG00000116292.1.
DR   GeneID; 327215; -.
DR   KEGG; dre:327215; -.
DR   CTD; 327215; -.
DR   ZFIN; ZDB-GENE-030131-5426; cul5a.
DR   eggNOG; KOG2285; Eukaryota.
DR   HOGENOM; CLU_004747_5_0_1; -.
DR   OMA; YRENFEA; -.
DR   OrthoDB; 5474206at2759; -.
DR   TreeFam; TF105874; -.
DR   Reactome; R-DRE-8863795; Downregulation of ERBB2 signaling.
DR   Reactome; R-DRE-8951664; Neddylation.
DR   Reactome; R-DRE-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000000437; Alternate scaffold 15.
DR   Proteomes; UP000000437; Chromosome 15.
DR   Bgee; ENSDARG00000069742; Expressed in muscle tissue and 20 other cell types or tissues.
DR   GO; GO:0031466; C:Cul5-RING ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF76; CULLIN-5; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   1: Evidence at protein level;
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:F1REN0};
KW   Receptor {ECO:0000313|RefSeq:NP_001314988.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          403..638
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   780 AA;  91013 MW;  D59CA4E88F3BD1D8 CRC64;
     MATSNLLKNK GSLQFEDKWD LMRPIVLKLL RQESVTKQQW FDQFSDVHAV CLWDDKGPAK
     IHQALKEDIL DFIKQAQARV LSHQDDTALL KAYIVEWRKF FTQCDILPKP FCQLEITLMG
     KQGSSKKSNV EDSIVRKLML DTWNESIFSN IKNRLQDSAM KLVHAERLGE AFDSQLVIGV
     RESYVNLCSN PEDKLQIYRD NFEKSYLDST ERFYRTQAPS YLQQNGVQNY MKYADAKLRE
     EEKRALRYLE TRRECNSVQA LMECCVNALV TSFKETILAE CPGMIKRNET DKLHLMFSLM
     DKVPNGIEPM LKDLEEHIIS AGLADMVAAA ETITTDSEKY VEQLLTLFNR FSKLVKEAFQ
     DDPRFLTARD KAYKAVVNDA TIFKLELPMK QKGVGLKTQP ESKCPELLAN YCDMLLRKTP
     LSKKLTSEDI ELKLKEVLLV LKYVQNKDVF MRYHKAHLTR RLILDISADS EIEENMVEWL
     REVGMPADYV NKLARMFQDI KVSEDLNQVF KEMHKHNKLA LPADSVNIKI LNAGAWSRSS
     EKVFVSLPTE LEDLIPEVED FYKKNHSGRK LHWHHLMSNG IITFKNEVGQ YDLEVTTFQL
     AVLFAWNQRP REKISFENLK LATELPDAEL RRTLWSLVAF PKLKRQVLLY EPQVSSPKDF
     TDSTLFFVNQ EFSLIKNSKA QKRGKINLIG RLQLTTERMR EEENEGIVQL RILRTQEAII
     QIMKMRKKIT NAQLQTELVE ILKNMFLPQK KMIKEQIEWL IEHKYIKRDE TDINTFIYMA
//
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